Present address: Clinical Chemistry, Slingeland Hospital, Doetinchem, The Netherlands.
The interaction of ibuprofen and diclofenac with aspirin in healthy volunteers
Article first published online: 19 MAY 2009
© 2009 The Authors. Journal compilation © 2009 The British Pharmacological Society
British Journal of Pharmacology
Volume 157, Issue 6, pages 931–934, July 2009
How to Cite
Schuijt, M., Huntjens-Fleuren, H., De Metz, M. and Vollaard, E. (2009), The interaction of ibuprofen and diclofenac with aspirin in healthy volunteers. British Journal of Pharmacology, 157: 931–934. doi: 10.1111/j.1476-5381.2009.00243.x
- Issue published online: 13 JUL 2009
- Article first published online: 19 MAY 2009
- Received 13 October 2008; revised 23 December 2008; accepted 29 January 2009
Background and purpose: Aspirin reduces the risk of myocardial infarction and stroke by inhibiting thromboxane production in platelets. This inhibition can be competitively antagonized by some non-steroidal anti-inflammatory drugs (NSAIDs).
Experimental approach: By measuring thromboxane B2 production in healthy volunteers, we investigated whether ibuprofen (800 mg three times daily for 7 days) or diclofenac (50 mg three times daily for 7 days) taken concurrently with aspirin 80 mg (once daily for 7 days) influenced the inhibitory effect of aspirin. The effects were compared with aspirin 30 mg (once daily for 7 days), which is the lowest dose of aspirin with a proven thromboprophylactic effect.
Key results: The median percentage inhibition of thromboxane B2 levels by 30 mg or 80 mg aspirin was 90.3% (range 83.1–96.0%) and 98.0% (range 96.8–99.2%) respectively. The inhibition by concurrent administration of slow release diclofenac and 80 mg aspirin was 98.1% (range 97.2–98.9%), indicating no interference between aspirin and diclofenac. The inhibition decreased significantly by concurrent administration of immediate release ibuprofen and 80 mg aspirin (86.6%; range 77.6–95.1%) to a level less than 30 mg aspirin.
Conclusions and implications: As alternatives are easily available, NSAIDs such as diclofenac should be preferred to ibuprofen for combined use with aspirin.