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Keywords:

  • histamine H4 receptor;
  • molecular pharmacology;
  • biochemistry;
  • signal transduction;
  • species difference;
  • isoforms;
  • heterogeneity;
  • selective agonists and antagonists

The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H4 receptor by several groups has been instrumental for a new appreciation of the role of histamine in the modulation of immune function. In this review, we summarize the historical developments and the molecular and biochemical pharmacology of the H4 receptor.