The molecular receptor nomenclature used throughout this commentary conforms to the BJP's Guide to Receptors and Channels (Alexander et al., 2009).
Phytocannabinoids beyond the Cannabis plant – do they exist?
Version of Record online: 11 MAR 2010
© 2010 The Authors. Journal compilation © 2010 The British Pharmacological Society
British Journal of Pharmacology
Special Issue: Themed Issue: Cannabinoids: Guest Editors: Steve Alexander, Ken Mackie and Ruth Ross
Volume 160, Issue 3, pages 523–529, June 2010
How to Cite
Gertsch, J., Pertwee, R. G. and Di Marzo, V. (2010), Phytocannabinoids beyond the Cannabis plant – do they exist?. British Journal of Pharmacology, 160: 523–529. doi: 10.1111/j.1476-5381.2010.00745.x
- Issue online: 19 MAY 2010
- Version of Record online: 11 MAR 2010
- Received 12 January 2010; revised 18 February 2010; accepted 23 February 2010
- plant natural products;
- endocannabinoid system
It is intriguing that during human cultural evolution man has detected plant natural products that appear to target key protein receptors of important physiological systems rather selectively. Plants containing such secondary metabolites usually belong to unique chemotaxa, induce potent pharmacological effects and have typically been used for recreational and medicinal purposes or as poisons. Cannabis sativa L. has a long history as a medicinal plant and was fundamental in the discovery of the endocannabinoid system. The major psychoactive Cannabis constituent Δ9-tetrahydrocannabinol (Δ9-THC) potently activates the G-protein-coupled cannabinoid receptor CB1 and also modulates the cannabinoid receptor CB2. In the last few years, several other non-cannabinoid plant constituents have been reported to bind to and functionally interact with CB receptors. Moreover, certain plant natural products, from both Cannabis and other plants, also target other proteins of the endocannabinoid system, such as hydrolytic enzymes that control endocannabinoid levels. In this commentary we summarize and critically discuss recent findings.
This article is part of a themed issue on Cannabinoids. To view the editorial for this themed issue visit http://dx.doi.org/10.1111/j.1476-5381.2010.00831.x