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To cite any of the articles below, please refer to the full article and not the DOI of this translations section. inline image

Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

RE Kast

Department of Psychiatry, University of Vermont, Burlington, VT, USA

inline image

Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

Georges Vauquelin1 and Steven J Charlton2

1Department of Molecular and Biochemical Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium, and2Novartis Institutes for Biomedical Research, Horsham, UK

inline image

Primate testing of TGN1412: right target, wrong cell inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

M Pallardy1 and T Hünig2

1Universud, Faculty of Pharmacy, INSERM UMR 996, Chatenay-Malabry, France, and2Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany

inline image

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

D Eastwood, L Findlay, S Poole, C Bird, M Wadhwa, M Moore, C Burns, R Thorpe and R Stebbings

Biotherapeutics Group, NIBSC, Potters Bar, Hertfordshire, UK

inline image

Control of vascular tone by purines and pyrimidines inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

Geoffrey Burnstock

Autonomic Neuroscience Centre, University College Medical School, Royal Free Campus, London, UK

inline image

Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

Markus Tölle, Mirjam Schuchardt, Annette Wiedon, Tao Huang, Lars Klöckel, Joachim Jankowski, Vera Jankowski, Walter Zidek and Markus van der Giet

Charité– Universitätsmedizin Berlin, Medical. Klinik mit Schwerpunkt Nephrologie, Hindenburgdamm 30, 12203 Berlin, Germany

inline image

Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

Feng Li, Peramaiyan Rajendran and Gautam Sethi

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

inline image

The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

A Rossi1,2, C Pergola1,3, A Koeberle3, M Hoffmann4, F Dehm1,3, P Bramanti2, S Cuzzocrea2,5, O Werz3 and L Sautebin1

1Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy,2IRCCS Centro Neurolesi ‘Bonino-Pulejo,’ Messina, Italy,3Department of Pharmaceutical Analytics, Pharmaceutical Institute, University Tuebingen, Tuebingen, Germany,4Institute of Pharmaceutical Chemistry, ZAFES, Goethe-University Frankfurt, D-60438 Frankfurt, Germany, and5Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy

inline image

Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

Morag K Mansley and Stuart M Wilson

Centre for Cardiovascular and Lung Biology, Division of Medical Sciences, College of Medicine, Dentistry and Nursing, University of Dundee, Dundee, UK

inline image

The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

S Frølund1, R Holm2, B Brodin1 and CU Nielsen1

1Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark, and2Preformulation, H. Lundbeck A/S, Copenhagen, Denmark

inline image

Alarin stimulates food intake and gonadotrophin release in male rats inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

CK Boughton, M Patterson, GA Bewick, JA Tadross, JV Gardiner, KEL Beale, F Chaudery, G Hunter, M Busbridge, EM Leavy, MA Ghatei, SR Bloom and KG Murphy

Department of Investigative Medicine, Imperial College London, Commonwealth Building, Du Cane Road, London, UK

inline image

Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

AP Larsen1, BH Bentzen1 and M Grunnet1,2

1The Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen N, Denmark, and2NeuroSearch A/S, Pederstrupvej 93, Ballerup, Denmark

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A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

NL Cluny1, VK Vemuri2, AP Chambers1, CL Limebeer3, H Bedard3, JT Wood2, B Lutz4, A Zimmer5, LA Parker3, A Makriyannis2 and KA Sharkey1

1Department of Physiology & Pharmacology, Hotchkiss Brain Institute and Snyder Institute of Infection, Immunity and Inflammation, University of Calgary, AB, Canada,2Center for Drug Discovery, Northeastern University, Boston, MA, USA,3Department of Psychology, University of Guelph, Guelph, Ontario, Canada,4Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany, and5Department of Molecular Psychiatry, University of Bonn, Bonn, Germany

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The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

Chin-Chung Wu1, Shih-Yun Wu1, Chieh-Yu Liao1, Che-Ming Teng2, Yang-Chang Wu1 and Sheng-Chu Kuo3

1Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan,2Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, and3Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan

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Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

TJ Searl and EM Silinsky

Department of Molecular Pharmacology and Biological Chemistry (MPBC), Northwestern University Medical School, Chicago, IL, USA

inline image

Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

Su Jing Chan, WSFred Wong, Peter TH Wong and Jin-Song Bian

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

inline image

Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

Hikaru Hashiatni1, Richard J Lang2 and Hikaru Suzuki1

1Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, and2Department of Physiology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia

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Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

R Vidal1,2,3, EM Valdizan1,2,3, MT Vilaró4,5, A Pazos1,2,3 and E Castro1,2,3

1Instituto de Biomedicina y Biotecnología (IBBTEC) (UC-CSIC-IDICAN), Santander, Cantabria,2Departamento de Fisiología y Farmacología, Universidad de Cantabria, Santander, Spain,3CIBERSAM, Ciber de Salud Mental, Instituto Carlos III, Spain,4Departamento de Neuroquímica y Neurofarmacología, Instituto de Investigaciones Biomédicas de Barcelona, CSIC-IDIBAPS, Barcelona, Spain, and5CIBERNED, Ciber de Enfermedades Neurodegenerativas, Instituto Carlos III, Spain

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Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

  1. Top of page
  2. Glioblastoma chemotherapy adjunct via potent serotonin receptor-7 inhibition using currently marketed high-affinity antipsychotic medicines inline image
  3. Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action inline image
  4. Primate testing of TGN1412: right target, wrong cell inline image
  5. Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells inline image
  6. Control of vascular tone by purines and pyrimidines inline image
  7. Differential effects of uridine adenosine tetraphosphateon purinoceptors in the rat isolated perfused kidney inline image
  8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway inline image
  9. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages inline image
  10. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption inline image
  11. The proton-coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly-Gly, Gly-Sar and other Gly-Gly mimetics inline image
  12. Alarin stimulates food intake and gonadotrophin release in male rats inline image
  13. Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels inline image
  14. A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents inline image
  15. The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation inline image
  16. Post-junctional interactions between neuromuscular blocking agents and ethanol at the mouse neuromuscular junction inline image
  17. Neuroprotective effects of andrographolide in a rat model of permanent cerebral ischaemia inline image
  18. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra inline image
  19. Reduced signal transduction by 5-HT4 receptors after long-term venlafaxine treatment in rats inline image
  20. Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception inline image

S Bang1, S Yoo1, TJ Yang1, H Cho2, YG Kim3 and SW Hwang1

1Korea University Graduate School of Medicine, Seoul, Korea,2Sensory Research Center, CRI, Seoul National University College of Pharmacy, Seoul, Korea, and3Department of Pharmacology, Dankook University College of Medicine, Cheonan, Korea

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