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Keywords:

  • Sphingosine-1-phosphate;
  • S1P;
  • cancer;
  • age-related macular degeneration;
  • wet AMD;
  • antibody therapeutics;
  • ocular disease;
  • choroidal neovascularization;
  • retinal pigmented epithelial cells

Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid thought to be dysregulated in a variety of disease conditions. In this review, we discuss the roles of S1P in cancer and in wet age-related macular degeneration. We also explore potential treatment strategies for these disorders, including the utility of anti-S1P antibodies acting as molecular sponges to neutralize dysregulated S1P in relevant tissues.