Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration


Roger A. Sabbadini, PhD, Lpath, Inc., 6335 Ferris Square, Suite A, San Diego, CA 92121, USA. E-mail: rsabbadini@lpath.com


Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid thought to be dysregulated in a variety of disease conditions. In this review, we discuss the roles of S1P in cancer and in wet age-related macular degeneration. We also explore potential treatment strategies for these disorders, including the utility of anti-S1P antibodies acting as molecular sponges to neutralize dysregulated S1P in relevant tissues.