SEARCH

SEARCH BY CITATION

References

  • Abazyan B, Nomura J, Kannan G, Ishizuka K, Tamashiro KL, Nucifora F et al. (2010). Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biol Psychiatry 68: 11721181.
  • Abdul-Monim Z, Reynolds GP, Neill JC (2006). The effect of atypical and classical antipsychotics on sub-chronic PCP-induced cognitive deficits in a reversal-learning paradigm. Behav Brain Res 169: 263273.
  • Abdul-Monim Z, Neill JC, Reynolds GP (2007). Sub-chronic psychotomimetic phencyclidine induces deficits in reversal learning and alterations in parvalbumin-immunoreactive expression in the rat. J Psychopharmacol 21: 198205.
  • Abekawa T, Honda M, Ito K, Inoue T, Koyama T (2002). Effect of MS-153 on the development of behavioral sensitization to locomotion- and ataxia-inducing effects of phencyclidine. Psychopharmacology (Berl) 160: 122131.
  • Akil M, Pierri JN, Whitehead RE, Edgar CL, Mohila C, Sampson AR et al. (1999). Lamina-specific alterations in the dopamine innervation of the prefrontal cortex in schizophrenic subjects. Am J Psychiatry 156: 15801589.
  • Al-Amin HA, Weinberger DR, Lipska BK (2000). Exaggerated MK-801-induced motor hyperactivity in rats with the neonatal lesion of the ventral hippocampus. Behav Pharmacol 11: 269278.
  • Allen N, Bagade S, McQueen M, Ioannidis J, Kavvoura F, Khoury M et al. (2008a). Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 40: 827834.
  • Allen NC, Bagade S, McQueen MB, Ioannidis JPA, Kavvoura FK, Khoury MJ et al. (2008b). Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 40: 827834.
  • Alquicer G, Silva-Gomez A, Peralta F, Flores G (2004). Neonatal ventral hippocampus lesion alters the dopamine content in the limbic regions in postpubertal rats. Int J Dev Neurosci 22: 103111.
  • Alquicer G, Morales-Medina JC, Quirion R, Flores G (2008). Postweaning social isolation enhances morphological changes in the neonatal ventral hippocampal lesion rat model of psychosis. J Chem Neuroanat 35: 179187.
  • Amitai N, Markou A (2009a). Chronic nicotine improves cognitive performance in a test of attention but does not attenuate cognitive disruption induced by repeated phencyclidine administration. Psychopharmacology (Berl) 202: 275286.
  • Amitai N, Markou A (2009b). Increased impulsivity and disrupted attention induced by repeated phencyclidine are not attenuated by chronic quetiapine treatment. Pharmacol Biochem Behav 93: 248257.
  • Amitai N, Semenova S, Markou A (2007). Cognitive–disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats. Psychopharmacology (Berl) 193: 521537.
  • Anastasio NC, Johnson KM (2008a). Atypical anti-schizophrenic drugs prevent changes in cortical N-methyl-d-aspartate receptors and behavior following sub-chronic phencyclidine administration in developing rat pups. Pharmacol Biochem Behav 90: 569577.
  • Anastasio NC, Johnson KM (2008b). Differential regulation of the NMDA receptor by acute and sub-chronic phencyclidine administration in the developing rat. J Neurochem 104: 12101218.
  • Andersen JD, Pouzet B (2004). Spatial memory deficits induced by perinatal treatment of rats with PCP and reversal effect of d-serine. Neuropsychopharmacology 29: 10801090.
  • Andreasen NC (1995). Symptoms, signs, and diagnosis of schizophrenia. Lancet 346: 477481.
  • Arguello P, Gogos J (2010). Cognition in mouse models of schizophrenia susceptibility genes. Schizophr Bull 36: 289300.
  • Baharnoori M, Bhardwaj S, Srivastava L (2010). Maternal lipopolysaccharide administration leads to developmental alterations in hippocampal neuronal density and expression of cortical dopaminergic receptors in ratoffspring. Schizophr Res 117: 271272.
  • Bakshi VP, Geyer MA (1999). Ontogeny of isolation rearing-induced deficits in sensorimotor gating in rats. Physiol Behav 67: 385392.
  • Bakshi VP, Swerdlow NR, Braff DL, Geyer MA (1998). Reversal of isolation rearing-induced deficits in prepulse inhibition by seroquel and olanzapine. Biol Psychiatry 43: 436445.
  • Balduini W, Elsner J, Lombardelli G, Peruzzi G, Cattabeni F (1991a). Teatment with methylazoxymethanol at different gestational days – 2-way shuttle box avoidance and residual maze activity in rat offspring. Neurotoxicology 12: 677686.
  • Balduini W, Lombardelli G, Peruzzi G, Cattabeni F (1991b). Treatment with methylazoxymethanol at different gestational days – physical, reflex development and spontaneous activity in the offspring. Neurotoxicology 12: 179188.
  • Barr AM, Powell SB, Markou A, Geyer MA (2006). Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats. Neuropharmacology 51: 457465.
  • Barr A, Fish K, Markou A, Honer W (2008). Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins. Eur J Neurosci 27: 25682574.
  • Bast T, Zhang WN, Feldon J (2001). Hyperactivity, decreased startle reactivity, and disrupted prepulse inhibition following disinhibition of the rat ventral hippocampus by the GABA(A) receptor antagonist picrotoxin. Psychopharmacology (Berl) 156: 225233.
  • Bayer SA, Altman J (1995). Neurogenesis and neuronal migration. In: Paxinos G (ed.). The Rat Nervous System, 2nd edn. Academic Press Inc: London, pp. 10411078.
  • Beasley CL, Zhang ZJ, Patten I, Reynolds GP (2002). Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins. Biol Psychiatry 52: 708715.
  • Becker A, Grecksch G, Bernstein HG, Hollt V, Bogerts B (1999). Social behaviour in rats lesioned with ibotenic acid in the hippocampus: quantitative and qualitative analysis. Psychopharmacology 144: 333338.
  • Bellon A, Le Pen G, Matricon J, Jay TM, Krebs MO (2009). Potential application as screening and drug designing tools of cytoarchitectural deficiencies present in three animal models of schizophrenia. Expert Opin Drug Discov 4: 257278.
  • Bendikov I, Nadri C, Amar S, Panizzutti R, De Miranda J, Wolosker H et al. (2007). A CSF and postmortem brain study of d-serine metabolic parameters in schizophrenia. Schizophr Res 90: 4151.
  • Beninger RJ, Tuerke KJ, Forsyth JK, Giles A, Xue LH, Boegman RJ et al. (2009). Neonatal ventral hippocampal lesions in male and female rats: effects on water maze, locomotor activity, plus-maze and prefrontal cortical GABA and glutamate release in adulthood. Behav Brain Res 202: 198209.
  • Beninger RJ, Beuk J, Banasikowski TJ, van Adel M, Boivin GA, Reynolds JN (2010). Subchronic phencyclidine in rats: alterations in locomotor activity, maze performance, and GABA(A) receptor binding. Behav Pharmacol 21: 110.
  • Beraki S, Kuzmin A, Tai F, Ogren SO (2008). Repeated low dose of phencyclidine administration impairs spatial learning in mice: blockade by clozapine but not by haloperidol. Eur Neuropsychopharmacol 18: 486497.
  • Bhardwaj S, Baharnoori M, Sharif-Askari B, Kamath A, Williams S, Srivastava L (2009). Behavioral characterization of dysbindin-1 deficient sandy mice. Behav Brain Res 197: 435441.
  • Bianchi M, Fone KFC, Azmi N, Heidbreder CA, Hagan JJ, Marsden CA (2006). Isolation rearing induces recognition memory deficits accompanied by cytoskeletal alterations in rat hippocampus. Eur J Neurosci 24: 28942902.
  • Birrell JM, Brown VJ (2000). Medial frontal cortex mediates perceptual attentional set shifting in the rat. J Neurosci 20: 43204324.
  • Bitanihirwe BK, Peleg-Raibstein D, Mouttet F, Feldon J, Meyer U (2010a). Late prenatal immune activation in mice leads to behavioral and neurochemical abnormalities relevant to the negative symptoms of schizophrenia. Neuropsychopharmacology 35: 24622478.
  • Bitanihirwe BKY, Weber L, Feldon J, Meyer U (2010b). Cognitive impairment following prenatal immune challenge in mice correlates with prefrontal cortical AKT1 deficiency. Int J Neuropsychopharmacol 13: 981996.
  • Bloomfield C, French SJ, Jones DNC, Reavill C, Southam E, Cilia J et al. (2008). Chandelier cartridges in the prefrontal cortex are reduced in isolation reared rats. Synapse 62: 628631.
  • Boctor SY, Ferguson SA (2009). Neonatal NMDA receptor antagonist treatments have no effects on prepulse inhibition of postnatal day 25 Sprague-Dawley rats. Neurotoxicology 30: 151154.
  • Boctor SY, Ferguson SA (2010). Altered adult locomotor activity in rats from phencyclidine treatment on postnatal days 7, 9 and 11, but not repeated ketamine treatment on postnatal day 7. Neurotoxicology 31: 4254.
  • Boksa P (2010). Effects of prenatal infection on brain development and behavior: a review of findings from animal models. Brain Behav Immun 24: 881897.
  • Borrell J, Vela JM, Arevalo-Martin A, Molina-Holgado E, Guaza C (2002). Prenatal immune challenge disrupts sensorimotor gating in adult rats: implications for the etiopathogenesis of schizophrenia. Neuropsychopharmacology 26: 204215.
  • Brady AM, Saul RD, Wiest MK (2010). Selective deficits in spatial working memory in the neonatal ventral hippocampal lesion rat model of schizophrenia. Neuropharmacology 59: 605611.
  • Braff DL, Geyer MA, Swerdlow NR (2001). Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology 156: 234258.
  • Braff D, Freedman R, Schork N, Gottesman I (2007). Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull 33: 2132.
  • Brake WG, Sullivan RM, Flores G, Srivastava LK, Gratton A (1999). Neonatal ventral hippocampal lesions attenuate the nucleus accumbens dopamine response to stress: an electrochemical study in the adult rat. Brain Res 831: 2532.
  • Braun I, Genius J, Grunze H, Bender A, Moller HJ, Rujescu D (2007). Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA. Schizophr Res 97: 254263.
  • Brigman JL, Ihne J, Saksida LM, Bussey TJ, Holmes A (2009). Effects of subchronic phencyclidine (PCP) treatment on social behaviors, and operant discrimination and reversal learning in C57BL/6J mice. Front Behav Neurosci 3: 2.
  • Broberg BV, Glenthoj BY, Dias R, Larsen DB, Olsen CK (2009). Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia – sub-chronic and early postnatal PCP treatment in attentional set-shifting. Psychopharmacology (Berl) 206: 631640.
  • Brown AS (2011). The environment and susceptibility to schizophrenia. Prog Neurobiol 93: 2358.
  • Brown AS, Derkits EJ (2010). Prenatal infection and schizophrenia: a review of epidemiologic and translational studies. Am J Psychiatry 167: 261280.
  • Bullock WM, Bolognani F, Botta P, Valenzuela CF, Perrone-Bizzozero NI (2009). Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine. Neurochem Int 55: 775782.
  • van den Buuse M (2010). Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects. Schizophr Bull 36: 246270.
  • van den Buuse M, Wischhof L, Lee R, Martin S, Karl T (2009). Neuregulin 1 hypomorphic mutant mice: enhanced baseline locomotor activity but normal psychotropic drug-induced hyperlocomotion and prepulse inhibition regulation. Int J Neuropsychopharmacol 12: 13831393.
  • Carpenter WT, Koenig JI (2008). The evolution of drug development in schizophrenia: past issues and future opportunities. Neuropsychopharmacology 33: 20612079.
  • Cassidy AW, Mulvany SK, Pangalos MN, Murphy KJ, Regan CM (2010a). Developmental emergence of reelin deficits in the prefrontal cortex of Wistar rats reared in social isolation. Neuroscience 166: 377385.
  • Cassidy AW, Mulvany SK, Pangalos MN, Murphy KJ, Regan CM (2010b). Reduced reelin protein synthesis in ventral hippocampus of isolation reared Wistar rats accompanies impaired avoidance conditioning. Behav Brain Res 213: 130134.
  • Cattabeni F, DiLuca M (1997). Developmental models of brain dysfunctions induced by targeted cellular ablations with methylazoxymethanol. Physiol Rev 77: 199215.
  • Cattabeni F, Abbracchio MP, Cimino M, Cocchi D, Diluca M, Mennuni L et al. (1989). Methylazoxymethanol-induced microencephaly: persistent increase of cortical somatostatin-like immunoreactivity. Brain Res Dev Brain Res 47: 156159.
  • Chambers RA, Self DW (2002). Motivational responses to natural and drug rewards in rats with neonatal ventral hippocampal lesions: an animal model of dual diagnosis schizophrenia. Neuropsychopharmacology 27: 889905.
  • Chambers RA, Moore J, McEvoy JP, Levin ED (1996). Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia. Neuropsychopharmacology 15: 587594.
  • Chen X, Feng Y, Hao C, Guo X, He X, Zhou Z et al. (2008). DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release. J Cell Biol 181: 791801.
  • Choi YK, Snigdha S, Shahid M, Neill JC, Tarazi FI (2009). Subchronic effects of phencyclidine on dopamine and serotonin receptors: implications for schizophrenia. J Mol Neurosci 38: 227235.
  • Cilia J, Reavill C, Hagan JJ, Jones DNC (2001). Long-term evaluation of isolation-rearing induced prepulse inhibition deficits in rats. Psychopharmacology 156: 327337.
  • Cilia J, Cluderay JE, Robbins MJ, Reavill C, Southam E, Kew JN et al. (2005a). Reversal of isolation-rearing-induced PPI deficits by an alpha7 nicotinic receptor agonist. Psychopharmacology (Berl) 182: 214219.
  • Cilia J, Hatcher PD, Reavill C, Jones DNC (2005b). Long-term evaluation of isolation-rearing induced prepulse inhibition deficits in rats: an update. Psychopharmacology 180: 5762.
  • Clapcote S, Lipina T, Millar J, Mackie S, Christie S, Ogawa F et al. (2007). Behavioral phenotypes of Disc1 missense mutations in mice. Neuron 54: 387402.
  • Clark M, Johnson BG, Wright RA, Monn JA, Schoepp DD (2002). Effects of the mGlu2/3 receptor agonist LY379268 on motor activity in phencyclidine-sensitized rats. Pharmacol Biochem Behav 73: 339346.
  • Cochran SM, Kennedy M, McKerchar CE, Steward LJ, Pratt JA, Morris BJ (2003). Induction of metabolic hypofunction and neurochemical deficits after chronic intermittent exposure to phencyclidine: differential modulation by antipsychotic drugs. Neuropsychopharmacology 28: 265275.
  • Cohen BD, Rosenbaum G, Luby ED, Gottlieb JS (1962). Comparison of phencyclidine hydrochloride (sernyl) with other drugs: simulation of schizophrenic performance with phencyclidine hydrochloride (sernyl), lysergic acid diethylamide (LSD-25), and amobarbital (amytal) sodium; II. Symbolic and sequential thinking. Arch Gen Psychiatry 6: 395401.
  • Cools AR, Brachten R, Heeren D, Willemen A, Ellenbroek B (1990). Search after neurobiological profile of individual-specific features of Wistar rats. Brain Res Bull 24: 4969.
  • Cools AR, Dierx J, Coenders C, Heeren D, Ried S, Jenks BG et al. (1993a). Apomorphine-susceptible and apomorphine-unsusceptible Wistar rats differ in novelty-induced changes in hippocampal dynorphin-B expression and 2-way active avoidance – a new key in the search for the role of the hippocampal accumbens axis. Behav Brain Res 55: 213221.
  • Cools AR, Rots NY, Ellenbroek B, Dekloet ER (1993b). Bimodal shape of individual variation in behavior of Wistar rats – the overall outcome of a fundamentally different make-up and reactivity of the brain, the endocrinological and the immunological system. Neuropsychobiology 28: 100105.
  • Cosgrove J, Newell TG (1991). Recovery of neuropsychological functions during reduction in use of phencyclidine. J Clin Psychol 47: 159169.
  • Cox M, Tucker A, Tang J, Talbot K, Richer D, Yeh L et al. (2009). Neurobehavioral abnormalities in the dysbindin-1 mutant, sandy, on a C57BL/6J genetic background. Genes Brain Behav 8: 390397.
  • Coyle JT, Tsai G, Goff D (2003). Converging evidence of NMDA receptor hypofunction in the pathophysiology of schizophrenia. Ann N Y Acad Sci 1003: 318327.
  • Dalley JW, Theobald DE, Pereira EAC, Li P, Robbins TW (2002). Specific abnormalities in serotonin release in the prefrontal cortex of isolation-reared rats measured during behavioural performance of a task assessing visuospatial attention and impulsivity. Psychopharmacology 164: 329340.
  • Day-Wilson KM, Jones DNC, Southam E, Cilia J, Totterdell S (2006). Medial prefrontal cortex volume loss in rats with isolation rearing-induced deficits in prepulse inhibition of acoustic startle. Neuroscience 141: 11131121.
  • Degen SB, Ellenbroek BA, Wiegant VM, Cools AR (2005). The development of various somatic markers is retarded in an animal model for schizophrenia, namely apomorphine-susceptible rats. Behav Brain Res 157: 369377.
  • Del Arco A, Zhu SW, Terasmaa A, Mohammed AH, Fuxe K (2004). Hyperactivity to novelty induced by social isolation is not correlated with changes in D2 receptor function and binding in striatum. Psychopharmacology 171: 148155.
  • Depoortere R, Dargazanli G, Estenne-Bouhtou G, Coste A, Lanneau C, Desvignes C et al. (2005). Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology 30: 19631985.
  • Dere E, Huston JP, De Souza Silva MA (2007). The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents. Neurosci Biobehav Rev 31: 673704.
  • Desbonnet L, Waddington JL, O'Tuathaigh CM (2009). Mutant models for genes associated with schizophrenia. Biochem Soc Trans 37: 308312.
  • Didriksen M, Skarsfeldt T, Arnt J (2007). Reversal of PCP-induced learning and memory deficits in the Morris' water maze by sertindole and other antipsychotics. Psychopharmacology (Berl) 193: 225233.
  • DiLuca M, Caputi A, Cattabeni F, DeGraan PNE, Gispen WH, Raiteri M et al. (1997). Increased presynaptic protein kinase C activity and glutamate release in rats with a prenatally induced hippocampal lesion. Eur J Neurosci 9: 472479.
  • Duffy L, Cappas E, Scimone A, Schofield P, Karl T (2008). Behavioral profile of a heterozygous mutant mouse model for EGF-like domain neuregulin 1. Behav Neurosci 122: 748759.
  • Duncan EJ, Szilagyi S, Efferen TR, Schwartz MP, Parwani A, Chakravorty S et al. (2003). Effect of treatment status on prepulse inhibition of acoustic startle in schizophrenia. Psychopharmacology 167: 6371.
  • Dunn LA, Atwater GE, Kilts CD (1993). Effects of antipsychotic-drugs on latent inhibition – sensitivity and specificity of an animal behavioral-model of clinical drug action. Psychopharmacology 112: 315323.
  • Egerton A, Reid L, McKerchar CE, Morris BJ, Pratt JA (2005). Impairment in perceptual attentional set-shifting following PCP administration: a rodent model of set-shifting deficits in schizophrenia. Psychopharmacology (Berl) 179: 7784.
  • Egerton A, Reid L, McGregor S, Cochran SM, Morris BJ, Pratt JA (2008). Subchronic and chronic PCP treatment produces temporally distinct deficits in attentional set shifting and prepulse inhibition in rats. Psychopharmacology (Berl) 198: 3749.
  • Ehrhardt J, Sabel BA, Schroeder U (1999). Subchronically applied phencyclidine fails to disrupt prepulse inhibition in rats. Eur Neuropsychopharmacol 10: 6974.
  • Ehrlichman R, Luminais S, White S, Rudnick N, Ma N, Dow H et al. (2009). Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions. Brain Res 1294: 116127.
  • Einon DF, Morgan MJ (1977). A critical period for social isolation in the rat. Dev Psychobiol 10: 123132.
  • Ellenbroek BA, Cools AR (2000). Animal models for the negative symptoms of schizophrenia. Behav Pharmacol 11: 223233.
  • Ellenbroek BA, Cools AR (2002). Apomorphine susceptibility and animal models for psychopathology: genes and environment. Behav Genet 32: 349361.
  • van der Elst MCJ, Roubos EW, Ellenbroek BA, Veening JG, Cools AR (2005). Apomorphine-susceptible rats and apomorphine-unsusceptible rats differ in the tyrosine hydroxylase-immunoreactive network in the nucleus accumbens core and shell. Exp Brain Res 160: 418423.
  • van Elst LT, Valerius G, Buchert M, Thiel T, Rusch N, Bubl E et al. (2005). Increased prefrontal and hippocampal glutamate concentration in schizophrenia: evidence from a magnetic resonance spectroscopy study. Biol Psychiatry 58: 724730.
  • Endo K, Hori T, Abe S, Asada T (2007). Alterations in GABA(A) receptor expression in neonatal ventral hippocampal lesioned rats: comparison of prepubertal and postpubertal periods. Synapse 61: 357366.
  • Fabricius K, Helboe L, Fink-Jensen A, Wortwein G, Steiniger-Brach B (2010a). Pharmacological characterization of social isolation-induced hyperactivity. Psychopharmacology (Berl) DOI: 10.1007/s00213-00010-02128-00219.
  • Fabricius K, Helboe L, Fink-Jensen A, Wortwein G, Steiniger-Brach B, Sotty F (2010b). Increased dopaminergic activity in socially isolated rats: an electrophysiological study. Neurosci Lett 482: 117122.
  • Fattorini G, Melone M, Bragina L, Candiracci C, Cozzi A, Pellegrini Giampietro DE et al. (2008). GLT-1 expression and Glu uptake in rat cerebral cortex are increased by phencyclidine. Glia 56: 13201327.
  • Fauman MA, Fauman BJ (1978). The psychiatric aspects of chronic phencyclidine use: a study of chronic PCP users. NIDA Res Monogr 21: 183200.
  • Featherstone RE, Kapur S, Fletcher PJ (2007a). The amphetamine-induced sensitized state as a model of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 31: 15561571.
  • Featherstone RE, Rizos Z, Nobrega JN, Kapur S, Fletcher PJ (2007b). Gestational methylazoxymethanol acetate treatment impairs select cognitive functions: parallels to schizophrenia. Neuropsychopharmacology 32: 483492.
  • Featherstone RE, Rizos Z, Kapur S, Fletcher PJ (2008). A sensitizing regimen of amphetamine that disrupts attentional set-shifting does not disrupt working or long-term memory. Behav Brain Res 189: 170179.
  • Feng Y, Zhou Z, He X, Wang H, Guo X, Hao C et al. (2008). Dysbindin deficiency in sandy mice causes reduction of snapin and displays behaviors related to schizophrenia. Schizophr Res 106: 218228.
  • Ferdman N, Murmu RP, Bock J, Braun K, Leshem M (2007). Weaning age, social isolation, and gender, interact to determine adult explorative and social behavior, and dendritic and spine morphology in prefrontal cortex of rats. Behav Brain Res 180: 174182.
  • Fiore M, Talamini L, Angelucci F, Koch T, Aloe L, Korf J (1999). Prenatal methylazoxymethanol acetate alters behavior and brain NGF levels in young rats: a possible correlation with the development of schizophrenia-like deficits. Neuropharmacology 38: 857869.
  • Fiore M, Grace AA, Korf J, Stampachiacchiere B, Aloe L (2004). Impaired brain development in the rat following prenatal exposure to methylazoxymethanol acetate at gestational day 17 and neurotrophin distribution. Neuroreport 15: 17911795.
  • Fiore M, Di Fausto V, Iannitelli A, Aloe L (2008). Clozapine or haloperidol in rats prenatally exposed to methylazoxymethanol, a compound inducing entorhinal–hippocampal deficits, alter brain and blood neurotrophins' concentrations. Ann Ist Super Sanita 44: 167177.
  • Flagstad P, Mork A, Glenthoj BY, van Beek J, Michael-Titus AT, Didriksen M (2004). Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbens. Neuropsychopharmacology 29: 20522064.
  • Fletcher PJ, Tenn CC, Rizos Z, Lovic V, Kapur S (2005). Sensitization to amphetamine, but not PCP, impairs attentional set shifting: reversal by a D1 receptor agonist injected into the medial prefrontal cortex. Psychopharmacology (Berl) 183: 190200.
  • Fletcher PJ, Tenn CC, Sinyard J, Rizos Z, Kapur S (2007). A sensitizing regimen of amphetamine impairs visual attention in the 5-choice serial reaction time test: reversal by a D1 receptor agonist injected into the medial prefrontal cortex. Neuropsychopharmacology 32: 11221132.
  • Flores G, Alquicer G, Silva-Gomez AB, Zaldivar G, Stewart J, Quirion R et al. (2005). Alterations in dendritic morphology of prefrontal cortical and nucleus accumbens neurons in post-pubertal rats after neonatal excitotoxic lesions of the ventral hippocampus. Neuroscience 133: 463470.
  • Flores C, Wen XL, Labelle-Dumais C, Kolb B (2007). Chronic phencyclidine treatment increases dendritic spine density in prefrontal cortex and nucleus accumbens neurons. Synapse 61: 978984.
  • Floresco SB, Geyer MA, Gold LH, Grace AA (2005). Developing predictive animal models and establishing a preclinical trials network for assessing treatment effects on cognition in schizophrenia. Schizophr Bull 31: 888894.
  • Fone KCF, Porkess MV (2008). Behavioural and neurochemical effects of post-weaning social isolation in rodents – relevance to developmental neuropsychiatric disorders. Neurosci Biobehav Rev 32: 10871102.
  • Fone KC, Shalders K, Fox ZD, Arthur R, Marsden CA (1996). Increased 5-HT2C receptor responsiveness occurs on rearing rats in social isolation. Psychopharmacology (Berl) 123: 346352.
  • Fortier ME, Joober R, Luheshi GN, Boksa P (2004). Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring. J Psychiatr Res 38: 335345.
  • Fortier ME, Luheshi GN, Boksa P (2007). Effects of prenatal infection on prepulse inhibition in the rat depend on the nature of the infectious agent and the stage of pregnancy. Behav Brain Res 181: 270277.
  • Fulford AJ, Marsden CA (1998a). Conditioned release of 5-hydroxytryptamine in vivo in the nucleus accumbens following isolation-rearing in the rat. Neuroscience 83: 481487.
  • Fulford AJ, Marsden CA (1998b). Effect of isolation-rearing on conditioned dopamine release in vivo in the nucleus accumbens of the rat. J Neurochem 70: 384390.
  • Fulford AJ, Marsden CA (2007). An intact dopaminergic system is required for context-conditioned release of 5-HT in the nucleus accumbens of postweaning isolation-reared rats. Neuroscience 149: 392400.
  • Gartlon JE, Barnes SA, Jones DNC (2006). Comparison of subchronic PCP dosing regimes as animal models of schizophrenia. J Psychopharmacol 20: A44A44.
  • Geyer MA, Wilkinson LS, Humby T, Robbins TW (1993). Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biol Psychiatry 34: 361372.
  • Geyer MA, Krebs-Thomson K, Varty GB (1999). The effects of M100907 in pharmacological and developmental animal models of prepulse inhibition deficits in schizophrenia. Neuropsychopharmacology 21: S134S142.
  • Geyer MA, Krebs-Thomson K, Braff DL, Swerdlow NR (2001). Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology 156: 117154.
  • Goetghebeur P, Dias R (2009). Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat – a back translational study. Psychopharmacology (Berl) 202: 287293.
  • Gogos JA, Gerber DJ (2006). Schizophrenia susceptibility genes: emergence of positional candidates and future directions. Trends Pharmacol Sci 27: 226233.
  • Goldman-Rakic PS, Castner SA, Svensson TH, Siever LJ, Williams GV (2004). Targeting the dopamine D-1 receptor in schizophrenia: insights for cognitive dysfunction. Psychopharmacology 174: 316.
  • Golub M, Germann S, Lloyd K (2004). Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse. Behav Brain Res 153: 159170.
  • Gottesman I, Gould TD (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160: 636645.
  • Gourevitch R, Rocher C, Le Pen G, Krebs MO, Jay TM (2004). Working memory deficits in adult rats after prenatal disruption of neurogenesis. Behav Pharmacol 15: 287292.
  • Gray JA, Roth BL (2007). Molecular targets for treating cognitive dysfunction in schizophrenia. Schizophr Bull 33: 11001119.
  • Grayson B, Idris NF, Neill JC (2007). Atypical antipsychotics attenuate a sub-chronic PCP-induced cognitive deficit in the novel object recognition task in the rat. Behav Brain Res 184: 3138.
  • Guidotti A, Auta J, Davis JM, Gerevini VD, Dwivedi Y, Grayson DR et al. (2000). Decrease in reelin and glutamic acid decarboxylase(67) (GAD(67)) expression in schizophrenia and bipolar disorder – a postmortem brain study. Arch Gen Psychiatry 57: 10611069.
  • Guidotti A, Auta J, Davis JM, Dong EB, Grayson DR, Veldic M et al. (2005). GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon. Psychopharmacology 180: 191205.
  • Hagan JJ, Jones DNC (2005). Predicting drug efficacy for cognitive deficits in schizophrenia. Schizophr Bull 31: 830853.
  • Hahn CG, Wang HY, Cho DS, Talbot K, Gur RE, Berrettini WH et al. (2006). Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat Med 12: 824828.
  • Hajszan T, Leranth C, Roth RH (2006). Subchronic phencyclidine treatment decreases the number of dendritic spine synapses in the rat prefrontal cortex. Biol Psychiatry 60: 639644.
  • Hall FS, Huang S, Fong GW, Pert A, Linnoila M (1998a). Effects of isolation rearing on locomotion, anxiety and responses to ethanol in Fawn Hooded and Wistar rats. Psychopharmacology 139: 203209.
  • Hall FS, Wilkinson LS, Humby T, Inglis W, Kendall DA, Marsden CA et al. (1998b). Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems. Pharmacol Biochem Behav 59: 859872.
  • Hall FS, Ghaed S, Pert A, Xing G (2002). The effects of isolation rearing on glutamate receptor NMDAR1A mRNA expression determined by in situ hybridization in Fawn hooded and Wistar rats. Pharmacol Biochem Behav 73: 185191.
  • Hanania T, Hillman GR, Johnson KM (1999). Augmentation of locomotor activity by chronic phencyclidine is associated with an increase in striatal NMDA receptor function and an upregulation of the NR1 receptor subunit. Synapse 31: 229239.
  • Harich S, Gross G, Bespalov A (2007). Stimulation of the metabotropic glutamate 2/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment. Psychopharmacology (Berl) 192: 511519.
  • Harris LW, Sharp T, Gartlon J, Jones DN, Harrison PJ (2003). Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism. Eur J Neurosci 18: 17061710.
  • Harrison PJ (2004). The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications. Psychopharmacology (Berl) 174: 151162.
  • Harrison P, Law A (2006a). Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry 60: 132140.
  • Harrison PJ, Law AJ (2006b). Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol Psychiatry 60: 132140.
  • Harrison PJ, Weinberger DR (2005). Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10: 4068.
  • Harte MK, Powell SB, Swerdlow NR, Geyer MA, Reynolds GP (2007). Deficits in parvalbumin and calbindin immunoreactive cells in the hippocampus of isolation reared rats. J Neural Transm 114: 893898.
  • Hazane F, Krebs MO, Jay TM, Le Pen G (2009). Behavioral perturbations after prenatal neurogenesis disturbance in female rat. Neurotox Res 15: 311320.
  • Heidbreder CA, Weiss IC, Domeney AM, Pryce C, Homberg J, Hedou G et al. (2000). Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome. Neuroscience 100: 749768.
  • Heidbreder CA, Foxton R, Cilia J, Hughes ZA, Shah AJ, Atkins A et al. (2001). Increased responsiveness of dopamine to atypical, but not typical antipsychotics in the medial prefrontal cortex of rats reared in isolation. Psychopharmacology (Berl) 156: 338351.
  • Hertzmann M, Reba RC, Kotlyarov EV (1990). Single photon emission computed tomography in phencyclidine and related drug abuse. Am J Psychiatry 147: 255256.
  • Hikida T, Jaaro-Peled H, Seshadr iS, Oishi K, Hookway C, Kong S et al. (2007). Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans. Proc Natl Acad Sci USA 104: 1450114506.
  • Hirayasu Y, Tanaka S, Shenton ME, Salisbury DF, DeSantis MA, Levitt JJ et al. (2001). Prefrontal gray matter volume reduction in first episode schizophrenia. Cereb Cortex 11: 374381.
  • Hori T, Subramaniam S, Srivastava LK, Quirion R (2000). Behavioral and neurochemical alterations following repeated phencyclidine administration in rats with neonatal ventral hippocampal lesions. Neuropharmacology 39: 24782491.
  • Howes SR, Dalley JW, Morrison CH, Robbins TW, Everitt BJ (2000). Leftward shift in the acquisition of cocaine self-administration in isolation-reared rats: relationship to extracellular levels of dopamine, serotonin and glutamate in the nucleus accumbens and amygdala-striatal FOS expression. Psychopharmacology (Berl) 151: 5563.
  • Ibi D, Takuma K, Koike H, Mizoguchi H, Tsuritani K, Kuwahara Y et al. (2008). Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice. J Neurochem 105: 921932.
  • Idris N, Neill J, Grayson B, Bang-Andersen B, Witten LM, Brennum LT et al. (2010). Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms. Psychopharmacology (Berl) 208: 2336.
  • Ito HT, Smith SEP, Hsiao E, Patterson PH (2010). Maternal immune activation alters nonspatial information processing in the hippocampus of the adult offspring. Brain Behav Immun 24: 930941.
  • Jaaro-Peled H (2009). Gene models of schizophrenia: DISC1 mouse models. Prog Brain Res 179: 7586.
  • Jaaro-Peled H, Ayhan Y, Pletnikov M, Sawa A (2010). Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models. Schizophr Bull 36: 301313.
  • Javitt DC, Zukin SR (1991). Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 148: 13011308.
  • Jazbec S, Pantelis C, Robbins T, Weickert T, Weinberger DR, Goldberg TE (2007). Intra-dimensional/extra-dimensional set-shifting performance in schizophrenia: impact of distractors. Schizophr Res 89: 339349.
  • Jenkins TA, Harte MK, McKibben CE, Elliott JJ, Reynolds GP (2008). Disturbances in social interaction occur along with pathophysiological deficits following sub-chronic phencyclidine administration in the rat. Behav Brain Res 194: 230235.
  • Jenkins TA, Harte MK, Reynolds GP (2010). Effect of subchronic phencyclidine administration on sucrose preference and hippocampal parvalbumin immunoreactivity in the rat. Neurosci Lett 471: 144147.
  • Jentsch JD, Roth RH (1999). The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 20: 201225.
  • Jentsch JD, Taylor JR (2001). Impaired inhibition of conditioned responses produced by subchronic administration of phencyclidine to rats. Neuropsychopharmacology 24: 6674.
  • Jentsch JD, Redmond DE Jr, Elsworth JD, Taylor JR, Youngren KD, Roth RH (1997a). Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine. Science 277: 953955.
  • Jentsch JD, Tran A, Le D, Youngren KD, Roth RH (1997b). Subchronic phencyclidine administration reduces mesoprefrontal dopamine utilization and impairs prefrontal cortical-dependent cognition in the rat. Neuropsychopharmacology 17: 9299.
  • Jentsch JD, Taylor JR, Roth RH (1998). Subchronic phencyclidine administration increases mesolimbic dopaminergic system responsivity and augments stress- and psychostimulant-induced hyperlocomotion. Neuropsychopharmacology 19: 105113.
  • Johnson KM, Phillips M, Wang C, Kevetter GA (1998). Chronic phencyclidine induces behavioral sensitization and apoptotic cell death in the olfactory and piriform cortex. J Neurosci Res 52: 709722.
  • Johnson K, Ryan L, Davis J, Elmore A, Guenther B, Marcus J et al. (2006). Application of magnetic resonance imaging in developmental neurotoxicity testing: a pilot study. Neurotoxicology 27: 846851.
  • Jones C, Brown AM, Auer DP, Fone KCF (2011). The mGluR2/3 agonist LY379268 reverses post-weaning social isolation induced recognition memory deficits in the rat. Psychopharmacology (Berl) 214: 269283.
  • Jones GH, Hernandez TD, Kendall DA, Marsden CA, Robbins TW (1992). Dopaminergic and serotonergic function following isolation rearing in rats: study of behavioural responses and postmortem and in vivo neurochemistry. Pharmacol Biochem Behav 43: 1735.
  • Jongen-Relo AL, Leng A, Luber M, Pothuizen HHJ, Weber L, Feldon J (2004). The prenatal methylazoxymethanol acetate treatment: a neurodevelopmental animal model for schizophrenia? Behav Brain Res 149: 159181.
  • Kalinichev M, Robbins MJ, Hartfield EM, Maycox PR, Moore SH, Savage KM et al. (2007). Comparison between intraperitoneal and subcutaneous phencyclidine administration in Sprague-Dawley rats: a locomotor activity and gene induction study. Prog Neuropsychopharmacol Biol Psychiatry 32: 414422.
  • Karlsgodt K, Robleto K, Trantham-Davidson H, Jairl C, Cannon T, Lavin A et al. (2011). Reduced dysbindin expression mediates N-methyl-d-aspartate receptor hypofunction and impaired working memory performance. Biol Psychiatry 69: 2834.
  • Kato T, Kasai A, Mizuno M, Liang FY, Shintani N, Maeda S et al. (2010). Phenotypic characterization of transgenic mice overexpressing neuregulin-1. PLoS ONE 5: e14185.
  • Kawabe K, Miyamoto E (2008). Effects of neonatal repeated MK-801 treatment on delayed non matching-to-position responses in rats. Neuroreport 19: 969973.
  • Kawabe K, Iwasaki T, Ichitani Y (2007). Repeated treatment with N-methyl-d-aspartate antagonists in neonatal, but not adult, rats causes long-term deficits of radial-arm maze learning. Brain Res 1169: 7786.
  • Keefe RS, Bilder RM, Davis SM, Harvey PD, Palmer BW, Gold JM et al. (2007). Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial. Arch Gen Psychiatry 64: 633647.
  • Kim JH, Vezina P (2002). The mGlu2/3 receptor agonist LY379268 blocks the expression of locomotor sensitization by amphetamine. Pharmacol Biochem Behav 73: 333337.
  • King MV, Fone KCF, Shacham S, Gannon KS (2007). The novel 5-HT6 receptor antagonist, PRX-07037, enhances memory and reduces food intake in a neurodevelopmental model of schizophrenia. J Psychopharmacol 21: A57.
  • King MV, Seeman P, Marsden CA, Fone KCF (2009). Increased dopamine D-2(high) receptors in rats reared in social isolation. Synapse 63: 476483.
  • Koenig JI, Elmer GI, Shepard PD, Lee PR, Mayo C, Joy B et al. (2005). Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia. Behav Brain Res 156: 251261.
  • Koike H, Arguello P, Kvajo M, Karayiorgou M, Gogos J (2006). Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci USA 103: 36933697.
  • Konradi C, Heckers S (2003). Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment. Pharmacol Ther 97: 153179.
  • Krueger D, Howell J, Hebert B, Olausson P, Taylor J, Nairn A (2006). Assessment of cognitive function in the heterozygous reeler mouse. Psychopharmacology (Berl) 189: 95104.
  • Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD et al. (1994). Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 51: 199214.
  • Kvajo M, McKellar H, Arguello P, Drew L, Moore H, MacDermott A et al. (2008). A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition. Proc Natl Acad Sci USA 105: 70767081.
  • Lapiz MD, Mateo Y, Parker T, Marsden C (2000). Effects of noradrenaline depletion in the brain on response on novelty in isolation-reared rats. Psychopharmacology (Berl) 152: 312320.
  • Lapiz MD, Mateo Y, Durkin S, Parker T, Marsden CA (2001). Effects of central noradrenaline depletion by the selective neurotoxin DSP-4 on the behaviour of the isolated rat in the elevated plus maze and water maze. Psychopharmacology (Berl) 155: 251259.
  • Lapiz MD, Fulford A, Muchimapura S, Mason R, Parker T, Marsden CA (2003). Influence of postweaning social isolation in the rat on brain development, conditioned behavior, and neurotransmission. Neurosci Behav Physiol 33: 1329.
  • Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R et al. (2006). Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5′ SNPs associated with the disease. Proc Natl Acad Sci USA 103: 67476752.
  • Le Cozannet R, Fone KC, Moran PM (2010). Phencyclidine withdrawal disrupts episodic-like memory in rats: reversal by donepezil but not clozapine. Int J Neuropsychopharmacol 13: 10111020.
  • Le Pen G, Grottick AJ, Higgins GA, Martin JR, Jenck F, Moreau JL (2000). Spatial and associative learning deficits induced by neonatal excitotoxic hippocampal damage in rats: further evaluation of an animal model of schizophrenia. Behav Pharmacol 11: 257268.
  • Le Pen G, Gourevitch R, Hazane F, Hoareau C, Jay TM, Krebs MO (2006). Peri-pubertal maturation after developmental disturbance: a model for psychosis onset in the rat. Neuroscience 143: 395405.
  • Lee PR, Brady DL, Shapiro RA, Dorsa DM, Koenig JI (2005). Social interaction deficits caused by chronic phencyclidine administration are reversed by oxytocin. Neuropsychopharmacology 30: 18831894.
  • Lee PR, Brady DL, Shapiro RA, Dorsa DM, Koenig JI (2007). Prenatal stress generates deficits in rat social behavior: reversal by oxytocin. Brain Res 1156: 152167.
  • Lei G, Anastasio NC, Fu Y, Neugebauer V, Johnson KM (2009). Activation of dopamine D1 receptors blocks phencyclidine-induced neurotoxicity by enhancing N-methyl-d-aspartate receptor-mediated synaptic strength. J Neurochem 109: 10171030.
  • Levin ED, Christopher NC (2006). Effects of clozapine on memory function in the rat neonatal hippocampal lesion model of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 30: 223229.
  • Levine JB, Youngs RM, MacDonald ML, Chu M, Leeder AD, Berthiaume F et al. (2007). Isolation rearing and hyperlocomotion are associated with reduced immediate early gene expression levels in the medial prefrontal cortex. Neuroscience 145: 4255.
  • Lewis DA, Levitt P (2002). Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci 25: 409432.
  • Lewis DA, Lieberman JA (2000). Catching up on schizophrenia: natural history and neurobiology. Neuron 28: 325334.
  • Li NX, Wu XH, Li L (2007a). Chronic administration of clozapine alleviates reversal-learning impairment in isolation-reared rats. Behav Pharmacol 18: 135145.
  • Li W, Zhou Y, Jentsch J, Brown R, Tian X, Ehninger D et al. (2007b). Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci USA 104: 1828018285.
  • Li Z, Kim CH, Ichikawa J, Meltzer HY (2003). Effect of repeated administration of phencyclidine on spatial performance in an eight-arm radial maze with delay in rats and mice. Pharmacol Biochem Behav 75: 335340.
  • Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO et al. (2005). Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 353: 12091223.
  • Linn GS, O'Keeffe RT, Lifshitz K, Schroeder C, Javitt DC (2007). Behavioral effects of orally administered glycine in socially housed monkeys chronically treated with phencyclidine. Psychopharmacology (Berl) 192: 2738.
  • Lipska BK (2004). Using animal models to test a neurodevelopmental hypothesis of schizophrenia. Rev Psychiatry Neurosci 29: 282286.
  • Lipska BK, Weinberger DR (1993). Delayed-effects of neonatal hippocampal damage on haloperidol-induced catalepsy and apomorphine-induced stereotypic behaviours in the rat. Brain Res Dev Brain Res 75: 213222.
  • Lipska BK, Weinberger DR (1994). Subchronic treatment with haloperidol and clozapine in rats with neonatal excitotoxic hippocampal damage. Neuropsychopharmacology 10: 199205.
  • Lipska BK, Jaskiw GE, Weinberger DR (1993). Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage – a potential animal-model of schizophrenia. Neuropsychopharmacology 9: 6775.
  • Lipska BK, Swerdlow NR, Geyer MA, Jaskiw GE, Braff DL, Weinberger DR (1995). Neonatal excitotoxic hippocampal damage in rats causes post pubertal changes in prepulse inhibition of startle and its disruption by apomorphine. Psychopharmacology 122: 3543.
  • Lipska BK, Aultman JM, Verma A, Weinberger DR, Moghaddam B (2002). Neonatal damage of the ventral hippocampus impairs working memory in the rat. Neuropsychopharmacology 27: 4754.
  • Lipska BK, Lerman DN, Khaing ZZ, Weickert CS, Weinberger DR (2003). Gene expression in dopamine and GABA systems in an animal model of schizophrenia: effects of antipsychotic drugs. Eur J Neurosci 18: 391402.
  • Liu F, Zou X, Sadovova N, Zhang X, Shi L, Guo L et al. (2010). Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia. Int J Dev Neurosci 29: 351358.
  • Liu W, Pesold C, Rodriguez M, Carboni G, Auta J, Lacor P et al. (2001). Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse. Proc Natl Acad Sci USA 98: 34773482.
  • Lodge DJ, Grace AA (2007). Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia. J Neurosci 27: 1142411430.
  • Lodge DJ, Grace AA (2008). Hippocampal dysfunction and disruption of dopamine system regulation in an animal model of schizophrenia. Neurotox Res 14: 97104.
  • Lodge DJ, Grace AA (2009). Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophrenia. Behav Brain Res 204: 306312.
  • Lodge DJ, Behrens MM, Grace AA (2009). A loss of parvalbumin-containing interneurons is associated with diminished oscillatory activity in an animal model of schizophrenia. J Neurosci 29: 23442354.
  • van Loo KM, Martens GJ (2007). Identification of genetic and epigenetic variations in a rat model for neurodevelopmental disorders. Behav Genet 37: 697705.
  • Lu W, Wolf ME (1999). Repeated amphetamine administration alters AMPA receptor subunit expression in rat nucleus accumbens and medial prefrontal cortex. Synapse 32: 119131.
  • Luby ED, Cohen BD, Rosenbaum G, Gottlieb JS, Kelley R (1959). Study of a new schizophrenomimetic drug; sernyl. AMA Arch Neurol Psychiatry 81: 363369.
  • Mackeprang T, Kristiansen KT, Glenthoj BY (2002). Effects of antipsychotics on prepulse inhibition of the startle response in drug-naive schizophrenic patients. Biol Psychiatry 52: 863873.
  • McKibben CE, Jenkins TA, Adams HN, Harte MK, Reynolds GP (2010). Effect of pretreatment with risperidone on phencyclidine-induced disruptions in object recognition memory and prefrontal cortex parvalbumin immunoreactivity in the rat. Behav Brain Res 208: 132136.
  • McLean SL, Woolley ML, Neill JC (2009). Effects of subchronic phencyclidine on behaviour of female rats on the elevated plus maze and open field. J Psychopharmacol 24: 787790.
  • McLean SL, Grayson B, Harris M, Protheroe C, Bate S, Woolley ML et al. (2010a). Isolation rearing impairs novel object recognition and attentional set shifting performance in female rats. J Psychopharmacol 24: 5763.
  • McLean SL, Neill JC, Idris NF, Marston HM, Wong EH, Shahid M (2010b). Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the rat. Behav Brain Res 214: 240247.
  • Malone DT, Kearn CS, Chongue L, Mackie K, Taylor DA (2008). Effect of social isolation on CB1 and D-2 receptor and fatty acid amide hydrolase expression in rats. Neuroscience 152: 265272.
  • Mansbach RS, Geyer MA (1989). Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat. Neuropsychopharmacology 2: 299308.
  • Mao CV, Hori E, Maior RS, Ono T, Nishijo H (2008). A primate model of schizophrenia using chronic PCP treatment. Rev Neurosci 19: 8389.
  • Marquis JP, Goulet S, Dore FY (2006). Neonatal lesions of the ventral hippocampus in rats lead to prefrontal cognitive deficits at two maturational stages. Neuroscience 140: 759767.
  • Marquis JP, Audet MC, Dore FY, Goulet S (2007). Delayed alternation performance following subchronic phencyclidine administration in rats depends on task parameters. Prog Neuropsychopharmacol Biol Psychiatry 31: 11081112.
  • Marquis JP, Goulet S, Dore FY (2008). Neonatal ventral hippocampus lesions disrupt extra-dimensional shift and alter dendritic spine density in the medial prefrontal cortex of juvenile rats. Neurobiol Learn Mem 90: 339346.
  • Marsden CA, King MV, Fone KCF (2011). Influence of social isolation in the rat on serotonergic function and memory – relevance to models of schizophrenia and the role of 5-HT6 receptors. Neuropharmacology DOI: 10.1016/j.neuropharm.2011.1003.1003.
  • Martinez V, Sarter M (2008). Detection of the moderately beneficial cognitive effects of low-dose treatment with haloperidol or clozapine in an animal model of the attentional impairments of schizophrenia. Neuropsychopharmacology 33: 26352647.
  • Martinez ZA, Ellison GD, Geyer MA, Swerdlow NR (1999). Effects of sustained phencyclidine exposure on sensorimotor gating of startle in rats. Neuropsychopharmacology 21: 2839.
  • Matricon J, Bellon A, Frieling H, Kebir O, Le Pen G, Beuvon F et al. (2010). Neuropathological and reelin deficiencies in the hippocampal formation of rats exposed to MAM; differences and similarities with schizophrenia. PLoS ONE 5: e10291.
  • Matsumot H, Higa HH (1966). Studies on methylazoxymethanol aglycone of cycasin – methylation of nucleic acids in vitro. Biochem J 98: C20C22.
  • Matsuzaki H, Minabe Y, Nakamura K, Suzuki K, Iwata Y, Sekine Y et al. (2007). Disruption of reelin signaling attenuates methamphetamine-induced hyperlocomotion. Eur J Neurosci 25: 33763384.
  • Meador-Woodruff JH, Healy DJ (2000). Glutamate receptor expression in schizophrenic brain. Brain Res Brain Res Rev 31: 288294.
  • Mei L, Xiong W (2008). Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nat Rev Neurosci 9: 437452.
  • Melendez RI, Gregory ML, Bardo MT, Kalivas PW (2004). Impoverished rearing environment alters metabotropic glutamate receptor expression and function in the prefrontal cortex. Neuropsychopharmacology 29: 19801987.
  • Meng ZH, Feldpaush DL, Merchant KM (1998). Clozapine and haloperidol block the induction of behavioral sensitization to amphetamine and associated genomic responses in rats. Brain Res Mol Brain Res 61: 3950.
  • Meyer U, Feldon J (2010). Epidemiology-driven neurodevelopmental animal models of schizophrenia. Prog Neurobiology 90: 285326.
  • Meyer U, Feldon J, Schedlowski M, Yee BK (2005). Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia. Neurosci Biobehav Rev 29: 913947.
  • Meyer U, Nyffeler M, Engler A, Urwyler A, Schedlowski M, Knuesel I et al. (2006a). The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology. J Neurosci 26: 47524762.
  • Meyer U, Schwendener S, Feldon J, Yee BK (2006b). Prenatal and postnatal maternal contributions in the infection model of schizophrenia. Exp Brain Res 173: 243257.
  • Meyer U, Feldon J, Fatemi SH (2009). In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders. Neurosci Biobehav Rev 33: 10611079.
  • Millan MJ, Brocco M (2008). Cognitive impairment in schizophrenia: a review of developmental and genetic models, and pro-cognitive profile of the optimised D-3 > D-2 antagonist, S33138. Therapie 63: 187229.
  • Millar J, Christie S, Anderson S, Lawson D, Hsiao-Wei Loh D, Devon R et al. (2001). Genomic structure and localisation within a linkage hotspot of disrupted in schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia. Mol Psychiatry 6: 173178.
  • Mintz J, Kopelowicz A (2007). CUtLASS confirms CATIE. Arch Gen Psychiatry 64: 978978.
  • Moore H, Jentsch JD, Ghajarnia M, Geyer MA, Grace AA (2006). A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia. Biol Psychiatry 60: 253264.
  • Morrow BA, Elsworth JD, Roth RH (2007). Repeated phencyclidine in monkeys results in loss of parvalbumin-containing axo-axonic projections in the prefrontal cortex. Psychopharmacology 192: 283290.
  • Moser PC, Hitchcock JM, Lister S, Moran PM (2000). The pharmacology of latent inhibition as an animal model of schizophrenia. Brain Res Brain Res Rev 33: 275307.
  • Mouri A, Noda Y, Enomoto T, Nabeshima T (2007). Phencyclidine animal models of schizophrenia: approaches from abnormality of glutamatergic neurotransmission and neurodevelopment. Neurochem Int 51: 173184.
  • Murai R, Noda Y, Matsui K, Kamei H, Mouri A, Matsuba K et al. (2007). Hypofunctional glutamatergic neurotransmission in the prefrontal cortex is involved in the emotional deficit induced by repeated treatment with phencyclidine in mice: implications for abnormalities of glutamate release and NMDA-CaMKII signaling. Behav Brain Res 180: 152160.
  • Murray RM, Lappin J, Di Forti M (2008). Schizophrenia: from developmental deviance to dopamine dysregulation. Eur Neuropsychopharmacol 18: S129S134.
  • Nagai T, Murai R, Matsui K, Kamei H, Noda Y, Furukawa H et al. (2009). Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D(1) and serotonin 5-HT (1A) receptors. Psychopharmacology (Berl) 202: 315328.
  • Nakatani-Pawlak A, Yamaguchi K, Tatsumi Y, Mizoguchi H, Yoneda Y (2009). Neonatal phencyclidine treatment in mice induces behavioral, histological and neurochemical abnormalities in adulthood. Biol Pharm Bull 32: 15761583.
  • Neill JC, Barnes S, Cook S, Grayson B, Idris NF, McLean SL et al. (2010). Animal models of cognitive dysfunction and negative symptoms of schizophrenia: focus on NMDA receptor antagonism. Pharmacol Ther 128: 419432.
  • Newell KA, Zavitsanou K, Huang XF (2007). Opposing short- and long-term effects on muscarinic M1/4 receptor binding following chronic phencyclidine treatment. J Neurosci Res 85: 13581363.
  • Nuechterlein KH, Barch DM, Gold JM, Goldberg TE, Green MF, Heaton RK (2004). Identification of separable cognitive factors in schizophrenia. Schizophr Res 72: 2939.
  • Nuechterlein KH, Robbins TW, Einat H (2005). Distinguishing separable domains of cognition in human and animal studies: what separations are optimal for targeting interventions? A summary of recommendations from breakout group 2 at the Measurement and Treatment Research to Improve Cognition in Schizophrenia New Approaches Conference. Schizophr Bull 31: 870874.
  • O'Donnell P, Lewis BL, Weinberger DR, Lipska BK (2002). Neonatal hippocampal damage alters electrophysiological properties of prefrontal cortical neurons in adult rats. Cereb Cortex 12: 975982.
  • O'Tuathaigh C, Babovic D, O'Sullivan G, Clifford J, Tighe O, Croke D et al. (2007). Phenotypic characterization of spatial cognition and social behavior in mice with ‘knockout’ of the schizophrenia risk gene neuregulin 1. Neuroscience 147: 1827.
  • O'Tuathaigh C, Waddington J (2010). Mutant mouse models: phenotypic relationships to domains of psychopathology and pathobiology in schizophrenia. Schizophr Bull 36: 243245.
  • O'Tuathaigh C, Kirby B, Moran P, Waddington J (2010). Mutant mouse models: genotype–phenotype relationships to negative symptoms in schizophrenia. Schizophr Bull 36: 271288.
  • Ognibene E, Adriani W, Caprioli A, Ghirardi O, Ali S, Aloe L et al. (2008). The effect of early maternal separation on brain derived neurotrophic factor and monoamine levels in adult heterozygous reeler mice. Prog Neuropsychopharmacol Biol Psychiatry 32: 12691276.
  • Olney JW, Farber NB (1995). Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 52: 9981007.
  • van Os J, Kenis G, Rutten BPF (2010). The environment and schizophrenia. Nature 468: 203212.
  • Ozawa K, Hashimoto K, Kishimoto T, Shimizu E, Ishikura H, Iyo M (2006). Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia. Biol Psychiatry 59: 546554.
  • Papaleo F, Yang F, Garcia S, Chen J, Lu B, Crawley J et al. (2010). Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways. Mol Psychiatry DOI: 10.1038/mp.2010.1106.
  • Park S, Holzman PS (1992). Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry 49: 975982.
  • Pascual R, Zamora-Leon SP (2007). Chronic (–)-deprenyl administration attenuates dendritic developmental impairment induced by early social isolation in the rat. Dev Neurosci 29: 261267.
  • Pascual R, Zamora-Leon SP, Valero-Cabre A (2006). Effects of postweaning social isolation and re-socialization on the expression of vasoactive intestinal peptide (VIP) and dendritic development in the medial prefrontal cortex of the rat. Acta Neurobiol Exp (Wars) 66: 714.
  • Patil ST, Zhang L, Martenyi F, Lowe SL, Jackson KA, Andreev BV et al. (2007). Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized phase 2 clinical trial. Nat Med 13: 11021107.
  • Pedersen CS, Goetghebeur P, Dias R (2009). Chronic infusion of PCP via osmotic mini-pumps: a new rodent model of cognitive deficit in schizophrenia characterized by impaired attentional set-shifting (ID/ED) performance. J Neurosci Methods 185: 6669.
  • Peleg-Raibstein D, Pezze MA, Ferger B, Zhang WN, Murphy CA, Feldon J et al. (2005). Activation of dopaminergic neurotransmission in the medial prefrontal cortex by N-methyl-d-aspartate stimulation of the ventral hippocampus in rats. Neuroscience 132: 219232.
  • Peleg-Raibstein D, Sydekum E, Russig H, Feldon J (2006). Withdrawal from repeated amphetamine administration leads to disruption of prepulse inhibition but not to disruption of latent inhibition. J Neural Transm 113: 13231336.
  • Penschuck S, Flagstad P, Didriksen M, Leist M, Michael-Titus AT (2006). Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia. Eur J Neurosci 23: 279284.
  • Phillips M, Wang C, Johnson KM (2001). Pharmacological characterization of locomotor sensitization induced by chronic phencyclidine administration. J Pharmacol Exp Ther 296: 905913.
  • Pizzagalli DA (2010). The ‘anhedonia paradox’ in schizophrenia: insights from affective neuroscience. Biol Psychiatry 67: 899901.
  • Pletnikov M, Ayhan Y, Nikolskaia O, Xu Y, Ovanesov M, Huang H et al. (2008). Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry 13: 173186.
  • Podhorna J, Didriksen M (2004). The heterozygous reeler mouse: behavioural phenotype. Behav Brain Res 153: 4354.
  • Powell CM, Miyakawa T (2006). Schizophrenia-relevant behavioral testing in rodent models: a uniquely human disorder? Biol Psychiatry 59: 11981207.
  • Powell SB, Geyer MA, Preece MA, Pitcher LK, Reynolds GP, Swerdlow NR (2003). Dopamine depletion of the nucleus accumbens reverses isolation-induced deficits in prepulse inhibition in rats. Neuroscience 119: 233240.
  • Qiao H, Noda Y, Kamei H, Nagai T, Furukawa H, Miura H et al. (2001). Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment. Neuroreport 12: 1115.
  • Qiu S, Korwek K, Pratt-Davis A, Peters M, Bergman M, Weeber E (2006). Cognitive disruption and altered hippocampus synaptic function in reelin haploinsufficient mice. Neurobiol Learn Mem 85: 228242.
  • Quan MN, Tian YT, Xu KH, Zhang T, Yang Z (2010). Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats. Neuroscience 169: 214222.
  • Rainey JM Jr, Crowder MK (1975). Prolonged psychosis attributed to phencyclidine: report of three cases. Am J Psychiatry 132: 10761078.
  • Rasmussen BA, O'Neil J, Manaye KF, Perry DC, Tizabi Y (2007). Long-term effects of developmental PCP administration on sensorimotor gating in male and female rats. Psychopharmacology 190: 4349.
  • Remington G (2003). Understanding antipsychotic ‘atypicality’: a clinical and pharmacological moving target. J Psychiatry Neurosci 28: 275284.
  • Reynolds GP, Abdul-Monim Z, Neill JC, Zhang ZJ (2004). Calcium binding protein markers of GABA deficits in schizophrenia – postmortem studies and animal models. Neurotox Res 6: 5761.
  • Reynolds LM, Cochran SM, Morris BJ, Pratt JA, Reynolds GP (2005). Chronic phencyclidine administration induces schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate in rat brain. Schizophr Res 73: 147152.
  • Richtand NM, Taylor B, Welge JA, Ahlbrand R, Ostrander MM, Burr J et al. (2006). Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions. Neuropsychopharmacology 31: 7789.
  • Rimer M, Barrett D, Maldonado M, Vock V, Gonzalez-Lima F (2005). Neuregulin-1 immunoglobulin-like domain mutant mice: clozapine sensitivity and impaired latent inhibition. Neuroreport 16: 271275.
  • Robinson TE, Becker JB (1986). Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Res 396: 157198.
  • Robinson TE, Kolb B (1999). Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine. Eur J Neurosci 11: 15981604.
  • Rodefer JS, Murphy ER, Baxter MG (2005). PDE10A inhibition reverses subchronic PCP-induced deficits in attentional set-shifting in rats. Eur J Neurosci 21: 10701076.
  • Romero E, Ali C, Molina-Holgado E, Castellano B, Guaza C, Borrell J (2007). Neurobehavioral and immunological consequences of prenatal immune activation in rats. Influence of antipsychotics. Neuropsychopharmacology 32: 17911804.
  • Roy K, Murtie J, El-Khodor B, Edgar N, Sardi S, Hooks B et al. (2007). Loss of ErbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders. Proc Natl Acad Sci USA 104: 81318136.
  • Rushe TM, Woodruff PWR, Murray RM, Morris RG (1999). Episodic memory and learning in patients with chronic schizophrenia. Schizophr Res 35: 8596.
  • Russig H, Durrer A, Yee BK, Murphy CA, Feldon J (2003). The acquisition, retention and reversal of spatial learning in the Morris water maze task following withdrawal from an escalating dosage schedule of amphetamine in Wistar rats. Neuroscience 119: 167179.
  • Salinger W, Ladrow P, Wheeler C (2003). Behavioral phenotype of the reeler mutant mouse: effects of RELN gene dosage and social isolation. Behav Neurosci 117: 12571275.
  • Sams-Dodd F (1995). Distinct effects of d-amphetamine and phencyclidine on the social behaviour of rats. Behav Pharmacol 6: 5565.
  • Sams-Dodd F (1996). Phencyclidine-induced stereotyped behaviour and social isolation in rats: a possible animal model of schizophrenia. Behav Pharmacol 7: 323.
  • Sams-Dodd F (1998). A test of the predictive validity of animal models of schizophrenia based on phencyclidine and d-amphetamine. Neuropsychopharmacology 18: 293304.
  • Sams-Dodd F, Lipska BK, Weinberger DR (1997). Neonatal lesions of the rat ventral hippocampus result in hyperlocomotion and deficits in social behaviour in adulthood. Psychopharmacology 132: 303310.
  • Sarter M, Martinez V, Kozak R (2009). A neurocognitive animal model dissociating between acute illness and remission periods of schizophrenia. Psychopharmacology (Berl) 202: 237258.
  • Savonenko A, Melnikova T, Laird F, Stewart K, Price D, Wong P (2008). Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proc Natl Acad Sci USA 105: 55855590.
  • Scalzo FM, Holson RR (1992). The ontogeny of behavioral sensitization to phencyclidine. Neurotoxicol Teratol 14: 714.
  • Schrijver NCA, Wurbel H (2001). Early social deprivation disrupts attentional, but not affective, shifts in rats. Behav Neurosci 115: 437442.
  • Schrijver NC, Bahr NI, Weiss IC, Wurbel H (2002). Dissociable effects of isolation rearing and environmental enrichment on exploration, spatial learning and HPA activity in adult rats. Pharmacol Biochem Behav 73: 209224.
  • Schrijver NC, Pallier PN, Brown VJ, Wurbel H (2004). Double dissociation of social and environmental stimulation on spatial learning and reversal learning in rats. Behav Brain Res 152: 307314.
  • Schubert MI, Porkess MV, Dashdorj N, Fone KCF, Auer DP (2009). Effects of social isolation rearing on the limbic brain: a combined behavioral and magnetic resonance imaging volumetry study in rats. Neuroscience 159: 2130.
  • Schwabe K, Brosda J, Wegener N, Koch M (2005). Clozapine enhances disruption of prepulse inhibition after sub-chronic dizocilpine- or phencyclidine-treatment in Wistar rats. Pharmacol Biochem Behav 80: 213219.
  • Scott L, Aperia A (2009). Interaction between N-methyl-d-aspartic acid receptors and D1 dopamine receptors: an important mechanism for brain plasticity. Neuroscience 158: 6266.
  • Seeman P, Schwarz J, Chen JF, Szechtman H, Perreault M, McKnight GS et al. (2006). Psychosis pathways converge via D2(high) dopamine receptors. Synapse 60: 319346.
  • Seillier A, Giuffrida A (2009). Evaluation of NMDA receptor models of schizophrenia: divergences in the behavioral effects of sub-chronic PCP and MK-801. Behav Brain Res 204: 410415.
  • Shen S, Lang B, Nakamoto C, Zhang F, Pu J, Kuan S et al. (2008). Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. J Neurosci 28: 1089310904.
  • Shenton ME, Dickey CC, Frumin M, McCarley RW (2001). A review of MRI findings in schizophrenia. Schizophr Res 49: 152.
  • Shi LM, Fatemi H, Sidwell RW, Patterson PH (2003). Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci 23: 297302.
  • Shigemi K, Tsuneyoshi Y, Yamada S, Kabuki Y, Hayamizu K, Denbow DM et al. (2010). Oral administration of l-serine reduces the locomotor activity of socially isolated rats. Neurosci Lett 468: 7579.
  • Shoval G, Weizman A (2005). The possible role of neurotrophins in the pathogenesis and therapy of schizophrenia. Eur Neuropsychopharmacol 15: 319329.
  • Silva-Gomez AB, Rojas D, Juarez I, Flores G (2003). Decreased dendritic spine density on prefrontal cortical and hippocampal pyramidal neurons in postweaning social isolation rats. Brain Res 983: 128136.
  • Sircar R (2000). Developmental maturation of the N-methyl-d-aspartic acid receptor channel complex in postnatal rat brain. Int J Dev Neurosci 18: 121131.
  • Sircar R (2003). Postnatal phencyclidine-induced deficit in adult water maze performance is associated with N-methyl-d-aspartate receptor upregulation. Int J Dev Neurosci 21: 159167.
  • Snigdha S, Horiguchi M, Huang M, Li Z, Shahid M, Neill JC et al. (2010). Attenuation of phencyclidine-induced object recognition deficits by the combination of atypical antipsychotic drugs and pimavanserin (ACP 103), a 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther 332: 622631.
  • Spano MS, Fadda P, Frau R, Fattore L, Fratta W (2010). Cannabinoid self-administration attenuates PCP-induced schizophrenia-like symptoms in adult rats. Eur Neuropsychopharmacol 20: 2536.
  • Srisurapanont M, Ali R, Marsden J, Sunga A, Wada K, Monteiro M (2003). Psychotic symptoms in methamphetamine psychotic in-patients. Int J Neuropsychopharmacol 6: 347352.
  • Stefani MR, Moghaddam B (2002). Effects of repeated treatment with amphetamine or phencyclidine on working memory in the rat. Behav Brain Res 134: 267274.
  • Stefani MR, Moghaddam B (2005). Transient N-methyl-d-aspartate receptor blockade in early development causes lasting cognitive deficits relevant to schizophrenia. Biol Psychiatry 57: 433436.
  • Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S et al. (2002). Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 71: 877892.
  • Sutcliffe JS, Marshall KM, Neill JC (2007). Influence of gender on working and spatial memory in the novel object recognition task in the rat. Behav Brain Res 177: 117125.
  • Swerdlow NR, Braff DL, Geyer MA (2000). Animal models of deficient sensorimotor gating: what we know, what we think we know and what we hope to know soon. Behav Pharmacol 11: 185204.
  • Takahashi M, Shirakawa O, Toyooka K, Kitamura N, Hashimoto T, Maeda K et al. (2000). Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients. Mol Psychiatry 5: 293300.
  • Takahashi M, Kakita A, Futamura T, Watanabe Y, Mizuno M, Sakimura K et al. (2006). Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine: comparison with adult treatment. J Neurochem 99: 770780.
  • Takao K, Toyama K, Nakanishi K, Hattori S, Takamura H, Takeda M et al. (2008). Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Mol Brain 1: 11.
  • Talamini LM, Koch T, Ter Horst GJ, Korf J (1998). Methylazoxymethanol acetate-induced abnormalities in the entorhinal cortex of the rat; parallels with morphological findings in schizophrenia. Brain Res 789: 293306.
  • Talamini LM, Ellenbroek B, Koch T, Korf J (2000). Impaired sensory gating and attention in rats with developmental abnormalities of the mesocortex – implications for schizophrenia. Ann N Y Acad Sci 911: 486494.
  • Tanibuchi Y, Fujita Y, Kohno M, Ishima T, Takatsu Y, Iyo M et al. (2009). Effects of quetiapine on phencyclidine-induced cognitive deficits in mice: a possible role of alpha1-adrenoceptors. Eur Neuropsychopharmacol 19: 861867.
  • Tenn CC, Kapur S, Fletcher PJ (2005). Sensitization to amphetamine, but not phencyclidine, disrupts prepulse inhibition and latent inhibition. Psychopharmacology (Berl) 180: 366376.
  • Toua C, Brand L, Moller M, Emsley RA, Harvey BH (2010). The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical N-methyl-d-aspartate and D1 receptor binding in rats. Neuroscience 165: 492499.
  • Tremolizzo L, Doueiri M, Dong E, Grayson D, Davis J, Pinna G et al. (2005). Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biol Psychiatry 57: 500509.
  • Tsai G, Coyle JT (2002). Glutamatergic mechanisms in schizophrenia. Annu Rev Pharmacol Toxicol 42: 165179.
  • Tseng KY, Chambers RA, Lipska BK (2009). The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia. Behav Brain Res 204: 295305.
  • Tueting P, Doueiri M, Guidotti A, Davis J, Costa E (2006). Reelin down-regulation in mice and psychosis endophenotypes. Neurosci Biobehav Rev 30: 10651077.
  • Tunstall B, Beckett S, Mason R (2009). Ultrasonic vocalisations explain unexpected effects on pre-pulse inhibition responses in rats chronically pre-treated with phencyclidine. Behav Brain Res 202: 184191.
  • Turnock-Jones JJ, Jennings CA, Robbins MJ, Cluderay JE, Cilia J, Reid JL et al. (2009). Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation. Synapse 63: 836846.
  • Tyson PJ, Laws KR, Roberts KH, Mortimer AM (2004). Stability of set-shifting and planning abilities in patients with schizophrenia. Psychiatry Res 129: 229239.
  • Uehara T, Sumiyoshi T, Seo T, Itoh H, Matsuoka T, Suzuki M et al. (2009). Long-term effects of neonatal MK-801 treatment on prepulse inhibition in young adult rats. Psychopharmacology 206: 623630.
  • Uehara T, Sumiyoshi T, Seo T, Matsuoka T, Itoh H, Suzuki M et al. (2010). Neonatal exposure to MK-801, an N-methyl-d-aspartate receptor antagonist, enhances methamphetamine-induced locomotion and disrupts sensorimotor gating in pre- and postpubertal rats. Brain Res 1352: 223230.
  • Valzelli L (1973). Isolation syndrome in mice. Psychopharmacologia 31: 305320.
  • Varty GB, Geyer MA (1998). Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats. Behav Neurosci 112: 14501457.
  • Varty GB, Higgins GA (1995). Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipychotic drugs. Psychopharmacology 112: 1526.
  • Varty GB, Marsden CA, Higgins GA (1999). Reduced synaptophysin immunoreactivity in the dentate gyrus of prepulse inhibition-impaired isolation-reared rats. Brain Res 824: 197203.
  • Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM et al. (2008). Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 320: 539543.
  • Wan RQ, Corbett R (1997). Enhancement of postsynaptic sensitivity to dopaminergic agonists induced by neonatal hippocampal lesions. Neuropsychopharmacology 16: 259268.
  • Wan RQ, Giovanni A, Kafka SH, Corbett R (1996). Neonatal hippocampal lesions induced hyperresponsiveness to amphetamine: behavioral and in vivo microdialysis studies. Behav Brain Res 78: 211223.
  • Wan RQ, Hartman H, Corbett R (1998). Alteration of dopamine metabolites in CSF and behavioral impairments induced by neonatal hippocampal lesions. Physiol Behav 65: 429436.
  • Wang CZ, Johnson KM (2005). Differential effects of acute and subchronic administration on phencyclidine-induced neuro degeneration in the perinatal rat. J Neurosci Res 81: 284292.
  • Wang C, McInnis J, Ross-Sanchez M, Shinnick-Gallagher P, Wiley JL, Johnson KM (2001). Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia. Neuroscience 107: 535550.
  • Watson DJG, Marsden CA, Millan MJ, Fone KCF (2011). Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment. Int J Neuropsychopharmacol DOI:10.1017/S1461145711000435.
  • Weickert C, Straub R, McClintock B, Matsumoto M, Hashimoto R, Hyde T et al. (2004). Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch Gen Psychiatry 61: 544555.
  • Weickert C, Rothmond D, Hyde T, Kleinman J, Straub R (2008). Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Schizophr Res 98: 105110.
  • Weiss IC, Feldon J (2001). Environmental animal models for sensorimotor gating deficiencies in schizophrenia: a review. Psychopharmacology 156: 305326.
  • Weiss IC, Feldon J, Domeney AM (1999). Isolation rearing-induced disruption of prepulse inhibition: further evidence for fragility of the response. Behav Pharmacol 10: 139149.
  • Weiss IC, Pryce CR, Jongen-Relo AL, Nanz-Bahr NI, Feldon J (2004). Effect of social isolation on stress-related behavioural and neuroendocrine state in the rat. Behav Brain Res 152: 279295.
  • Wiley JL, Buhler KG, Lavecchia KL, Johnson KM (2003). Pharmacological challenge reveals long-term effects of perinatal phencyclidine on delayed spatial alternation in rats. Prog Neuropsychopharmacol Biol Psychiatry 27: 867873.
  • Wilkinson LS, Killcross SS, Humby T, Hall FS, Geyer MA, Robbins TW (1994). Social-isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition. Neuropsychopharmacology 10: 6172.
  • Williams N, O'Donovan M, Owen M (2005). Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia? Schizophr Bull 31: 800805.
  • Winters BD, Saksida LM, Bussey TJ (2008). Object recognition memory: neurobiological mechanisms of encoding, consolidation and retrieval. Neurosci Biobehav Rev 32: 10551070.
  • Wiseman Harris L, Sharp T, Gartlon J, Jones DN, Harrison PJ (2003). Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism. Eur J Neurosci 18: 17061710.
  • Wood GK, Lipska BK, Weinberger DR (1997). Behavioral changes in rats with early ventral hippocampal damage vary with age at damage. Brain Res Dev Brain Res 101: 1725.
  • Xu X, Domino EF (1994). Phencyclidine-induced behavioral sensitization. Pharmacol Biochem Behav 47: 603608.
  • Young JW, Powell SB, Risbrough V, Marston HM, Geyer MA (2009). Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia. Pharmacol Ther 122: 150202.
  • Zhao XH, Sun L, Jia HX, Meng QX, Wu S, Li NX et al. (2009). Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats. Prog Neuropsychopharmacol Biol Psychiatry 33: 11731177.
  • Zuckerman L, Weiner I (2003). Post-pubertal emergence of disrupted latent inhibition following prenatal immune activation. Psychopharmacology 169: 308313.
  • Zuckerman L, Weiner I (2005). Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring. J Psychiatr Res 39: 311323.
  • Zuckerman L, Rehavi M, Nachman R, Weiner I (2003). Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia. Neuropsychopharmacology 28: 17781789.