Figure S1 Effect of HD mutation on the 8-OH-DPAT-induced hypothermia in male animals. (A) Using the 8-OH-DPAT-induced hypothermia we found that administration of the 5-HT1A agonist decreased rectal temperature [compared with baseline temperature (t0) and expressed in °C] in a dose- and time-dependent manner in all animals. (B) Considering the AUC for 1 h post injection, we also found a significant overall effect of DPAT treatment but no effect of genotype. Values represent means (±SEM) of n = 8–11 mice per group.

Figure S2 Effect of chronic treatment with sertraline or exercise on hippocampal gene expression. Hippocampal mRNA levels of 5-HT transporter (5-HTT) and GR were measured following chronic treatment with (A/C) sertraline (20 mg·kg−1) or (B/D) voluntary physical exercise (RW). None gene expression was affected by either the genotype or the treatment conditions. Values represent means (±SEM) of n = 3–4 mice per group.

BPH_1567_sm_FigureS1.jpg963KSupporting info item
BPH_1567_sm_FigureS2.jpg1501KSupporting info item

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.