Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise
Article first published online: 10 FEB 2012
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society
British Journal of Pharmacology
Volume 165, Issue 5, pages 1375–1389, March 2012
How to Cite
Renoir, T., Pang, T. Y., Zajac, M. S., Chan, G., Du, X., Leang, L., Chevarin, C., Lanfumey, L. and Hannan, A. J. (2012), Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise. British Journal of Pharmacology, 165: 1375–1389. doi: 10.1111/j.1476-5381.2011.01567.x
- Issue published online: 10 FEB 2012
- Article first published online: 10 FEB 2012
- Accepted manuscript online: 30 JUN 2011 01:45PM EST
- Received; 2 November 2010; Revised; 7 June 2011; Accepted; 16 June 2011
Figure S1 Effect of HD mutation on the 8-OH-DPAT-induced hypothermia in male animals. (A) Using the 8-OH-DPAT-induced hypothermia we found that administration of the 5-HT1A agonist decreased rectal temperature [compared with baseline temperature (t0) and expressed in °C] in a dose- and time-dependent manner in all animals. (B) Considering the AUC for 1 h post injection, we also found a significant overall effect of DPAT treatment but no effect of genotype. Values represent means (±SEM) of n = 8–11 mice per group.
Figure S2 Effect of chronic treatment with sertraline or exercise on hippocampal gene expression. Hippocampal mRNA levels of 5-HT transporter (5-HTT) and GR were measured following chronic treatment with (A/C) sertraline (20 mg·kg−1) or (B/D) voluntary physical exercise (RW). None gene expression was affected by either the genotype or the treatment conditions. Values represent means (±SEM) of n = 3–4 mice per group.
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