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Figure S1 Effect of HD mutation on the 8-OH-DPAT-induced hypothermia in male animals. (A) Using the 8-OH-DPAT-induced hypothermia we found that administration of the 5-HT1A agonist decreased rectal temperature [compared with baseline temperature (t0) and expressed in °C] in a dose- and time-dependent manner in all animals. (B) Considering the AUC for 1 h post injection, we also found a significant overall effect of DPAT treatment but no effect of genotype. Values represent means (±SEM) of n = 8–11 mice per group.

Figure S2 Effect of chronic treatment with sertraline or exercise on hippocampal gene expression. Hippocampal mRNA levels of 5-HT transporter (5-HTT) and GR were measured following chronic treatment with (A/C) sertraline (20 mg·kg−1) or (B/D) voluntary physical exercise (RW). None gene expression was affected by either the genotype or the treatment conditions. Values represent means (±SEM) of n = 3–4 mice per group.

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BPH_1567_sm_FigureS1.jpg963KSupporting info item
BPH_1567_sm_FigureS2.jpg1501KSupporting info item

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