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  • Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D et al. (1999). Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem 274: 1715917163.
  • Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R et al. (2001). LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology 120: 16891699.
  • Adachi H, Suzuki T, Abe M, Asano N, Mizutamari H, Tanemoto M et al. (2003). Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol 285: F1188F1197.
  • Aherne GW, Piall E, Marks V, Mould G, White WF (1978a). Prolongation and enhancement of serum methotrexate concentrations by probenecid. Br Med J 1: 10971099.
  • Aherne W, Piall E, Marks V (1978b). Radioimmunoassay of methotrexate: use of 75Se-labelled methotrexate. Ann Clin Biochem 15: 331334.
  • Akamine Y, Miura M, Sunagawa S, Kagaya H, Yasui-Furukori N, Uno T (2010). Influence of drug-transporter polymorphisms on the pharmacokinetics of fexofenadine enantiomers. Xenobiotica 40: 782789.
  • Alebouyeh M, Takeda M, Onozato ML, Tojo A, Noshiro R, Hasannejad H et al. (2003). Expression of human organic anion transporters in the choroid plexus and their interactions with neurotransmitter metabolites. J Pharmacol Sci 93: 430436.
  • Annaert P, Ye ZW, Stieger B, Augustijns P (2010). Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1. Xenobiotica 40: 163176.
  • Anzai N, Kanai Y, Endou H (2007). New insights into renal transport of urate. Curr Opin Rheumatol 19: 151157.
  • Asif AR, Steffgen J, Metten M, Grunewald RW, Muller GA, Bahn A et al. (2005). Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cells. Pflugers Arch 450: 8895.
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Enomoto A, Tojo A et al. (2002). Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim Biophys Acta 1590: 6475.
  • Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D et al. (2006). Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther 318: 521529.
  • Bahn A, Hagos Y, Reuter S, Balen D, Brzica H, Krick W et al. (2008). Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). J Biol Chem 283: 1633216341.
  • Bailey DG, Dresser GK, Leake BF, Kim RB (2007). Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. Clin Pharmacol Ther 81: 495502.
  • Baldes C, Koenig P, Neumann D, Lenhof HP, Kohlbacher O, Lehr CM (2006). Development of a fluorescence-based assay for screening of modulators of human organic anion transporter 1B3 (OATP1B3). Eur J Pharm Biopharm 62: 3943.
  • Barendt WM, Wright SH (2002). The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization. J Biol Chem 277: 2249122496.
  • Bleasby K, Hall LA, Perry JL, Mohrenweiser HW, Pritchard JB (2005). Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). J Pharmacol Exp Ther 314: 923931.
  • Bleasby K, Castle JC, Roberts CJ, Cheng C, Bailey WJ, Sina JF et al. (2006). Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition. Xenobiotica 36: 963988.
  • Bossuyt X, Muller M, Meier PJ (1996). Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J Hepatol 25: 733738.
  • Briz O, Serrano MA, Rebollo N, Hagenbuch B, Meier PJ, Koepsell H et al. (2002). Carriers involved in targeting the cytostatic bile acid-cisplatin derivatives cis-diammine-chloro-cholylglycinate-platinum(II) and cis-diammine-bisursodeoxycholate-platinum(II) toward liver cells. Mol Pharmacol 61: 853860.
  • Briz O, Serrano MA, MacIas RI, Gonzalez-Gallego J, Marin JJ (2003). Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin. Biochem J 371: 897905.
  • Briz O, Romero MR, Martinez-Becerra P, Macias RI, Perez MJ, Jimenez F et al. (2006). OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes? J Biol Chem 281: 3032630335.
  • Bronger H, Konig J, Kopplow K, Steiner HH, Ahmadi R, Herold-Mende C et al. (2005). ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. Cancer Res 65: 1141911428.
  • Burckhardt G, Burckhardt BC (2011). In vitro and in vivo evidence of the importance of organic anion transporters (OATs) in drug therapy. Handb Exp Pharmacol 201: 29104.
  • Busch AE, Karbach U, Miska D, Gorboulev V, Akhoundova A, Volk C et al. (1998). Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol 54: 342352.
  • Buyukkale G, Turker G, Kasap M, Akpinar G, Arisoy E, Gunlemez A et al. (2011). Neonatal Hyperbilirubinemia and Organic Anion Transporting Polypeptide-2 Gene Mutations. Am J Perinatol 28: 619626.
  • Campbell SD, de Morais SM, Xu JJ (2004). Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia. Chem Biol Interact 150: 179187.
  • Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK et al. (2000). Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem 275: 45074512.
  • Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T et al. (2001). Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol 59: 12771286.
  • Chang C, Pang KS, Swaan PW, Ekins S (2005). Comparative pharmacophore modeling of organic anion transporting polypeptides: a meta-analysis of rat Oatp1a1 and human OATP1B1. J Pharmacol Exp Ther 314: 533541.
  • Chen HL, Liu YJ, Wu SH, Ni YH, Ho MC, Lai HS et al. (2008). Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia. Pediatr Res 63: 667673.
  • Chi Y, Schuster VL (2010). The prostaglandin transporter PGT transports PGH(2). Biochem Biophys Res Commun 395: 168172.
  • Choi JH, Murray JW, Wolkoff AW (2011). PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1. Am J Physiol Gastrointest Liver Physiol 300: G384G393.
  • Chu XY, Bleasby K, Yabut J, Cai X, Chan GH, Hafey MJ et al. (2007). Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein. J Pharmacol Exp Ther 321: 673683.
  • Chung JY, Cho JY, Yu KS, Kim JR, Oh DS, Jung HR et al. (2005). Effect of OATP1B1 (SLCO1B1) variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers. Clin Pharmacol Ther 78: 342350.
  • Ciarimboli G (2008). Organic cation transporters. Xenobiotica 38: 936971.
  • Ciarimboli G, Schlatter E (2005). Regulation of organic cation transport. Pflugers Arch 449: 423441.
  • Cihlar T, Lin DC, Pritchard JB, Fuller MD, Mendel DB, Sweet DH (1999). The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Mol Pharmacol 56: 570580.
  • Congiu M, Mashford ML, Slavin JL, Desmond PV (2009). Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease. J Gastroenterol Hepatol 24: 10381044.
  • Cui T, Liu Y, Men X, Xu Z, Wu L, Liu S et al. (2009). Bile acid transport correlative protein mRNA expression profile in human placenta with intrahepatic cholestasis of pregnancy. Saudi Med J 30: 14061410.
  • Cui Y, Konig J, Leier I, Buchholz U, Keppler D (2001). Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem 276: 96269630.
  • Cui Y, Konig J, Nies AT, Pfannschmidt M, Hergt M, Franke WW et al. (2003). Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma. Lab Invest 83: 527538.
  • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB (1999). OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos 27: 866871.
  • van der Deure WM, Hansen PS, Peeters RP, Kyvik KO, Friesema EC, Hegedus L et al. (2008). Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation. Endocrinology 149: 53075314.
  • Dresser GK, Bailey DG, Leake BF, Schwarz UI, Dawson PA, Freeman DJ et al. (2002). Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther 71: 1120.
  • Dresser GK, Kim RB, Bailey DG (2005). Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides. Clin Pharmacol Ther 77: 170177.
  • Ekaratanawong S, Anzai N, Jutabha P, Miyazaki H, Noshiro R, Takeda M et al. (2004). Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules. J Pharmacol Sci 94: 297304.
  • Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH et al. (2002a). Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 417: 447452.
  • Enomoto A, Takeda M, Shimoda M, Narikawa S, Kobayashi Y, Yamamoto T et al. (2002b). Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther 301: 797802.
  • Enomoto A, Wempe MF, Tsuchida H, Shin HJ, Cha SH, Anzai N et al. (2002c). Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. J Biol Chem 277: 3626236271.
  • Eraly SA, Vallon V, Vaughn DA, Gangoiti JA, Richter K, Nagle M et al. (2006). Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice. J Biol Chem 281: 50725083.
  • Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M et al. (2006). The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Am J Physiol Renal Physiol 290: F905F912.
  • Fahrmayr C, Fromm MF, Konig J (2010). Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects. Drug Metab Rev 42: 380401.
  • Fehrenbach T, Cui Y, Faulstich H, Keppler D (2003). Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins. Naunyn Schmiedebergs Arch Pharmacol 368: 415420.
  • Fischer WJ, Altheimer S, Cattori V, Meier PJ, Dietrich DR, Hagenbuch B (2005). Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin. Toxicol Appl Pharmacol 203: 257263.
  • Franco R, Cidlowski JA (2006). SLCO/OATP-like transport of glutathione in FasL-induced apoptosis: glutathione efflux is coupled to an organic anion exchange and is necessary for the progression of the execution phase of apoptosis. J Biol Chem 281: 2954229557.
  • Franke RM, Baker SD, Mathijssen RH, Schuetz EG, Sparreboom A (2008). Influence of solute carriers on the pharmacokinetics of CYP3A4 probes. Clin Pharmacol Ther 84: 704709.
  • Fujino H, Saito T, Ogawa S, Kojima J (2005). Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol 57: 13051311.
  • Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ et al. (2005). Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenet Genomics 15: 201209.
  • Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M et al. (2001). Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology 142: 20052012.
  • Furihata T, Satoh T, Yamamoto N, Kobayashi K, Chiba K (2007). Hepatocyte nuclear factor 1 alpha is a factor responsible for the interindividual variation of OATP1B1 mRNA levels in adult Japanese livers. Pharm Res 24: 23272332.
  • Gao B, Hagenbuch B, Kullak-Ublick GA, Benke D, Aguzzi A, Meier PJ (2000). Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J Pharmacol Exp Ther 294: 7379.
  • Gao B, Huber RD, Wenzel A, Vavricka SR, Ismair MG, Reme C et al. (2005). Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium. Exp Eye Res 80: 6172.
  • van Giersbergen PL, Treiber A, Schneiter R, Dietrich H, Dingemanse J (2007). Inhibitory and inductive effects of rifampin on the pharmacokinetics of bosentan in healthy subjects. Clin Pharmacol Ther 81: 414419.
  • Glaeser H, Bailey DG, Dresser GK, Gregor JC, Schwarz UI, McGrath JS et al. (2007). Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther 81: 362370.
  • Glaeser H, Mandery K, Sticht H, Fromm MF, Konig J (2010). Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3. Br J Pharmacol 159: 698708.
  • Gong S, Lu X, Xu Y, Swiderski CF, Jordan CT, Moscow JA (2002). Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias. Exp Hematol 30: 11621169.
  • Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S et al. (1997). Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol 16: 871881.
  • Grube M, Meyer Zu Schwabedissen H, Draber K, Prager D, Moritz KU, Linnemann K et al. (2005). Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta. Drug Metab Dispos 33: 3137.
  • Grube M, Kock K, Karner S, Reuther S, Ritter CA, Jedlitschky G et al. (2006a). Modification of OATP2B1-mediated transport by steroid hormones. Mol Pharmacol 70: 17351741.
  • Grube M, Kock K, Oswald S, Draber K, Meissner K, Eckel L et al. (2006b). Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart. Clin Pharmacol Ther 80: 607620.
  • Grundemann D, Schechinger B, Rappold GA, Schomig E (1998). Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci 1: 349351.
  • Gui C, Hagenbuch B (2008). Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport. Biochemistry 47: 90909097.
  • Gui C, Hagenbuch B (2009). Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1. Protein Sci 18: 22982306.
  • Gui C, Miao Y, Thompson L, Wahlgren B, Mock M, Stieger B et al. (2008). Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol 584: 5765.
  • Gui C, Wahlgren B, Lushington GH, Hagenbuch B (2009). Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17beta-glucuronide transport. Pharmacol Res 60: 5056.
  • Gui C, Obaidat A, Chaguturu R, Hagenbuch B (2010). Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3. Curr Chem Genomics 4: 18.
  • Hagenbuch B, Gui C (2008). Xenobiotic transporters of the human organic anion transporting polypeptide (OATP) family. Xenobiotica 7–8: 778801.
  • Hagenbuch B, Meier PJ (2004). Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch 447: 653665.
  • Hamada A, Sissung T, Price DK, Danesi R, Chau CH, Sharifi N et al. (2008). Effect of SLCO1B3 haplotype on testosterone transport and clinical outcome in caucasian patients with androgen-independent prostatic cancer. Clin Cancer Res 14: 33123318.
  • Hanggi E, Grundschober AF, Leuthold S, Meier PJ, St-Pierre MV (2006). Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1. Mol Pharmacol 70: 806817.
  • Hartkoorn RC, Kwan WS, Shallcross V, Chaikan A, Liptrott N, Egan D et al. (2010). HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms. Pharmacogenet Genomics 20: 112120.
  • Hayer M, Bonisch H, Bruss M (1999). Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1). Ann Hum Genet 63: 473482.
  • Hilgendorf C, Ahlin G, Seithel A, Artursson P, Ungell AL, Karlsson J (2007). Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metab Dispos 35: 13331340.
  • Hirano M, Maeda K, Shitara Y, Sugiyama Y (2004). Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther 311: 139146.
  • Hirano M, Maeda K, Shitara Y, Sugiyama Y (2006). Drug-drug interaction between pitavastatin and various drugs via OATP1B1. Drug Metab Dispos 34: 12291236.
  • Ho RH, Tirona RG, Leake BF, Glaeser H, Lee W, Lemke CJ et al. (2006). Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology 130: 17931806.
  • Ho RH, Choi L, Lee W, Mayo G, Schwarz UI, Tirona RG et al. (2007). Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants. Pharmacogenet Genomics 17: 647656.
  • Hong M, Zhou F, You G (2004). Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1. J Biol Chem 279: 3147831482.
  • Hong M, Tanaka K, Pan Z, Ma J, You G (2007). Determination of the external loops and the cellular orientation of the N- and the C-termini of the human organic anion transporter hOAT1. Biochem J 401: 515520.
  • Horvath G, Schmid N, Fragoso MA, Schmid A, Conner GE, Salathe M et al. (2007). Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway. Am J Respir Cell Mol Biol 36: 5360.
  • Hosoyamada M, Sekine T, Kanai Y, Endou H (1999). Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol 276: F122F128.
  • Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP et al. (1999). A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem 274: 3716137168.
  • Hu S, Franke RM, Filipski KK, Hu C, Orwick SJ, de Bruijn EA et al. (2008). Interaction of imatinib with human organic ion carriers. Clin Cancer Res 14: 31413148.
  • Huang MJ, Kua KE, Teng HC, Tang KS, Weng HW, Huang CS (2004). Risk factors for severe hyperbilirubinemia in neonates. Pediatr Res 56: 682689.
  • Huber RD, Gao B, Sidler Pfandler MA, Zhang-Fu W, Leuthold S, Hagenbuch B et al. (2007). Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. Am J Physiol Cell Physiol 292: C795C806.
  • Ieiri I, Suzuki H, Kimura M, Takane H, Nishizato Y, Irie S et al. (2004). Influence of common variants in the pharmacokinetic genes (OATP-C, UGT1A1, and MRP2) on serum bilirubin levels in healthy subjects. Hepatol Res 30: 9195.
  • Ishiguro N, Maeda K, Kishimoto W, Saito A, Harada A, Ebner T et al. (2006). Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans. Drug Metab Dispos 34: 11091115.
  • Ismair MG, Stieger B, Cattori V, Hagenbuch B, Fried M, Meier PJ et al. (2001). Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver. Gastroenterology 121: 11851190.
  • Jonker JW, Wagenaar E, Mol CA, Buitelaar M, Koepsell H, Smit JW et al. (2001). Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene. Mol Cell Biol 21: 54715477.
  • Jonker JW, Wagenaar E, Van Eijl S, Schinkel AH (2003). Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations. Mol Cell Biol 23: 79027908.
  • Jung D, Kullak-Ublick GA (2003). Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression. Hepatology 37: 622631.
  • Kalgutkar AS, Feng B, Nguyen HT, Frederick KS, Campbell SD, Hatch HL et al. (2007). Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor (+)-2-[4-({[2-(benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methy l)-3-fluoro-phenoxy]-propionic acid in rat and human. Drug Metab Dispos 35: 21112118.
  • Kalliokoski A, Niemi M (2009). Impact of OATP transporters on pharmacokinetics. Br J Pharmacol 158: 693705.
  • Kalliokoski A, Neuvonen M, Neuvonen PJ, Niemi M (2008). No significant effect of SLCO1B1 polymorphism on the pharmacokinetics of rosiglitazone and pioglitazone. Br J Clin Pharmacol 65: 7886.
  • Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW, Schuster VL (1995). Identification and characterization of a prostaglandin transporter. Science 268: 866869.
  • Karbach U, Kricke J, Meyer-Wentrup F, Gorboulev V, Volk C, Loffing-Cueni D et al. (2000). Localization of organic cation transporters OCT1 and OCT2 in rat kidney. Am J Physiol Renal Physiol 279: F679F687.
  • Kato K, Shirasaka Y, Kuraoka E, Kikuchi A, Iguchi M, Suzuki H et al. (2010). Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport. Mol Pharmacol 7: 17471756.
  • Kato Y, Yoshida K, Watanabe C, Sai Y, Tsuji A (2004). Screening of the interaction between xenobiotic transporters and PDZ proteins. Pharm Res 21: 18861894.
  • Kato Y, Sai Y, Yoshida K, Watanabe C, Hirata T, Tsuji A (2005). PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2. Mol Pharmacol 67: 734743.
  • Kato Y, Miyazaki T, Kano T, Sugiura T, Kubo Y, Tsuji A (2009). Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci 98: 25292539.
  • Katz DA, Carr R, Grimm DR, Xiong H, Holley-Shanks R, Mueller T et al. (2006). Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics. Clin Pharmacol Ther 79: 186196.
  • Keitel V, Burdelski M, Warskulat U, Kuhlkamp T, Keppler D, Haussinger D et al. (2005). Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis. Hepatology 41: 11601172.
  • Keller T, Schwarz D, Bernhard F, Dotsch V, Hunte C, Gorboulev V et al. (2008). Cell free expression and functional reconstitution of eukaryotic drug transporters. Biochemistry 47: 45524564.
  • Kelley L, Sternberg M (2009). Protein structure prediction on the Web: a case study using the Phyre server. Nat Protoc 4: 363371.
  • Kerb R, Brinkmann U, Chatskaia N, Gorbunov D, Gorboulev V, Mornhinweg E et al. (2002). Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences. Pharmacogenetics 12: 591595.
  • Kikuchi R, Kusuhara H, Hattori N, Shiota K, Kim I, Gonzalez FJ et al. (2006). Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylation. Mol Pharmacol 70: 887896.
  • Kikuchi R, Kusuhara H, Hattori N, Kim I, Shiota K, Gonzalez FJ et al. (2007). Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation. Mol Pharmacol 72: 16191625.
  • Kindla J, Muller F, Mieth M, Fromm MF, Konig J (2011). Influence of non-steroidal anti-inflammatory drugs on Organic Anion Transporting Polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Drug Metab Dispos 39: 10471053.
  • Kinoshita M, Miyata M (2002). Underexpression of mRNA in human hepatocellular carcinoma focusing on eight loci. Hepatology 36: 433438.
  • Knauer MJ, Urquhart BL, Meyer zu Schwabedissen HE, Schwarz UI, Lemke CJ, Leake BF et al. (2010). Human skeletal muscle drug transporters determine local exposure and toxicity of statins. Circ Res 106: 297306.
  • Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I (2003). Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther 306: 703708.
  • Kock K, Koenen A, Giese B, Fraunholz M, May K, Siegmund W et al. (2010). Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization. J Biol Chem 285: 1133611347.
  • Koepsell H (2011). Substrate recognition and translocation by polyspecific organic cation transporters. Biol Chem 392: 95101.
  • Koepsell H, Lips K, Volk C (2007). Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res 24: 12271251.
  • Komatsu M, Furukawa T, Ikeda R, Takumi S, Nong Q, Aoyama K et al. (2007). Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3. Toxicol Sci 97: 407416.
  • Konig J (2011). Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug-drug interactions, and functional consequences of polymorphisms. Handb Exp Pharmacol 201: 128.
  • Konig J, Cui Y, Nies AT, Keppler D (2000a). Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem 275: 2316123168.
  • Konig J, Cui Y, Nies AT, Keppler D (2000b). A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol Gastrointest Liver Physiol 278: G156G164.
  • Kopplow K, Letschert K, Konig J, Walter B, Keppler D (2005). Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol 68: 10311038.
  • Kraft ME, Glaeser H, Mandery K, Konig J, Auge D, Fromm MF et al. (2010). The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. Invest Ophthalmol Vis Sci 51: 25042511.
  • Kullak-Ublick GA, Hagenbuch B, Stieger B, Schteingart CD, Hofmann AF, Wolkoff AW et al. (1995). Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 109: 12741282.
  • Kullak-Ublick GA, Beuers U, Fahney C, Hagenbuch B, Meier PJ, Paumgartner G (1997a). Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene. Hepatology 26: 991997.
  • Kullak-Ublick GA, Glasa J, Boker C, Oswald M, Grutzner U, Hagenbuch B et al. (1997b). Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. Gastroenterology 113: 12951305.
  • Kullak-Ublick GA, Fisch T, Oswald M, Hagenbuch B, Meier PJ, Beuers U et al. (1998). Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain. FEBS Lett 424: 173176.
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F et al. (2001). Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120: 525533.
  • Lahjouji K, Mitchell GA, Qureshi IA (2001). Carnitine transport by organic cation transporters and systemic carnitine deficiency. Mol Genet Metab 73: 287297.
  • Lamhonwah AM, Ackerley CA, Tilups A, Edwards VD, Wanders RJ, Tein I (2005). OCTN3 is a mammalian peroxisomal membrane carnitine transporter. Biochem Biophys Res Commun 338: 19661972.
  • Lau YY, Huang Y, Frassetto L, Benet LZ (2007). effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Clin Pharmacol Ther 81: 194204.
  • Le Vee M, Gripon P, Stieger B, Fardel O (2008). Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta. Drug Metab Dispos 36: 217222.
  • Le Vee M, Lecureur V, Moreau A, Stieger B, Fardel O (2009). Differential regulation of drug transporter expression by hepatocyte growth factor in primary human hepatocytes. Drug Metab Dispos 37: 22282235.
  • Le Vee M, Jouan E, Moreau A, Fardel O (2011). Regulation of drug transporter mRNA expression by interferon-gamma in primary human hepatocytes. Fundam Clin Pharmacol 25: 99103.
  • Lee SY, Williamson B, Caballero OL, Chen YT, Scanlan MJ, Ritter G et al. (2004). Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer. Cancer Immun 4: 1321.
  • Lee W, Glaeser H, Smith LH, Roberts RL, Moeckel GW, Gervasini G et al. (2005). Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. J Biol Chem 280: 96109617.
  • Lee W, Belkhiri A, Lockhart AC, Merchant N, Glaeser H, Harris EI et al. (2008). Overexpression of OATP1B3 confers apoptotic resistance in colon cancer. Cancer Res 68: 1031510323.
  • Letschert K, Keppler D, Konig J (2004). Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8). Pharmacogenetics 14: 441452.
  • Letschert K, Faulstich H, Keller D, Keppler D (2006). Molecular characterization and inhibition of amanitin uptake into human hepatocytes. Toxicol Sci 91: 140149.
  • Leuthold S, Hagenbuch B, Mohebbi N, Wagner CA, Meier PJ, Stieger B (2009). Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters. Am J Physiol Cell Physiol 296: C570C582.
  • Li L, Meier PJ, Ballatori N (2000). Oatp2 mediates bidirectional organic solute transport: a role for intracellular glutathione. Mol Pharmacol 58: 335340.
  • Li LQ, Lee TK, Meier PJ, Ballatori N (1998). Identification of glutathione as a driving force and leukotriene C-4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. J Biol Chem 273: 1618416191.
  • Lin Z, Nelson L, Franke A, Poritz L, Li TY, Wu R et al. (2010). OCTN1 variant L503F is associated with familial and sporadic inflammatory bowel disease. J Crohns Colitis 4: 132138.
  • Lips KS, Volk C, Schmitt BM, Pfeil U, Arndt P, Miska D et al. (2005). Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Am J Respir Cell Mol Biol 33: 7988.
  • Liu L, Cui Y, Chung AY, Shitara Y, Sugiyama Y, Keppler D et al. (2006). Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers. J Pharmacol Exp Ther 318: 395402.
  • Ljubojevic M, Balen D, Breljak D, Kusan M, Anzai N, Bahn A et al. (2007). Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones. Am J Physiol Renal Physiol 292: F361F372.
  • Lu R, Chan BS, Schuster VL (1999). Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol 276: F295F303.
  • Lu WJ, Tamai I, Nezu J, Lai ML, Huang JD (2006). Organic anion transporting polypeptide-C mediates arsenic uptake in HEK-293 cells. J Biomed Sci 13: 525533.
  • Maeda K, Ieiri I, Yasuda K, Fujino A, Fujiwara H, Otsubo K et al. (2006a). Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril. Clin Pharmacol Ther 79: 427439.
  • Maeda K, Kambara M, Tian Y, Hofmann AF, Sugiyama Y (2006b). Uptake of ursodeoxycholate and its conjugates by human hepatocytes: role of Na(+)-taurocholate cotransporting polypeptide (NTCP), organic anion transporting polypeptide (OATP) 1B1 (OATP-C), and oatp1B3 (OATP8). Mol Pharm 3: 7077.
  • Maeda T, Takahashi K, Ohtsu N, Oguma T, Ohnishi T, Atsumi R et al. (2007). Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Mol Pharm 4: 8594.
  • Mahagita C, Grassl SM, Piyachaturawat P, Ballatori N (2007). Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport. Am J Physiol Gastrointest Liver Physiol 293: G271G278.
  • Mandery K, Bujok K, Schmidt I, Wex T, Treiber G, Malfertheiner P et al. (2010). Influence of cyclooxygenase inhibitors on the function of the prostaglandin transporter organic anion-transporting polypeptide 2A1 expressed in human gastroduodenal mucosa. J Pharmacol Exp Ther 332: 345351.
  • Mandery K, Sticht H, Bujok K, Schmidt I, Fahrmayr C, Balk B et al. (2011). Functional and structural relevance of conserved positively charged lysine residues in organic anion transporting polypeptide 1B3. Mol Pharmacol 80: 400406.
  • Martinez-Becerra P, Briz O, Romero MR, Macias RI, Perez MJ, Sancho-Mateo C et al. (2011). Further characterization of the electrogenicity and pH sensitivity of the human organic anion-transporting polypeptides OATP1B1 and OATP1B3. Mol Pharmacol 79: 596607.
  • Masuda S, Terada T, Yonezawa A, Tanihara Y, Kishimoto K, Katsura T et al. (2006). Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. J Am Soc Nephrol 17: 21272135.
  • Meier PJ, Eckhardt U, Schroeder A, Hagenbuch B, Stieger B (1997). Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology 26: 16671677.
  • Meier-Abt F, Faulstich H, Hagenbuch B (2004). Identification of phalloidin uptake systems of rat and human liver. Biochim Biophys Acta 1664: 6469.
  • Meier-Abt F, Mokrab Y, Mizuguchi K (2005). Organic anion transporting polypeptides of the OATP/SLCO superfamily: identification of new members in nonmammalian species, comparative modeling and a potential transport mode. J Membr Biol 208: 213227.
  • Michalski C, Cui Y, Nies AT, Nuessler AK, Neuhaus P, Zanger UM et al. (2002). A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter. J Biol Chem 277: 4305843063.
  • Miki Y, Suzuki T, Kitada K, Yabuki N, Shibuya R, Moriya T et al. (2006). Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma. Cancer Res 66: 535542.
  • Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M et al. (2004). Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci U S A 101: 35693574.
  • Miura M, Satoh S, Inoue K, Kagaya H, Saito M, Inoue T et al. (2007). Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol 63: 11611169.
  • Miura M, Satoh S, Inoue K, Saito M, Habuchi T, Suzuki T (2009). Telmisartan pharmacokinetics in Japanese renal transplant recipients. Clin Chim Acta 399: 8387.
  • Miyagawa M, Maeda K, Aoyama A, Sugiyama Y (2009). The eighth and ninth transmembrane domains in organic anion transporting polypeptide 1B1 affect the transport kinetics of estrone-3-sulfate and estradiol-17beta-D-glucuronide. J Pharmacol Exp Ther 329: 551557.
  • Moaddel R, Ravichandran S, Bighi F, Yamaguchi R, Wainer IW (2007). Pharmacophore modelling of stereoselective binding to the human organic cation transporter (hOCT1). Br J Pharmacol 151: 13051314.
  • Monks NR, Liu S, Xu Y, Yu H, Bendelow AS, Moscow JA (2007). Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells. Mol Cancer Ther 6: 587598.
  • van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK et al. (1999). Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther 291: 147152.
  • Motohashi H, Sakurai Y, Saito H, Masuda S, Urakami Y, Goto M et al. (2002). Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol 13: 866874.
  • Mougey EB, Feng H, Castro M, Irvin CG, Lima JJ (2009). Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response. Pharmacogenet Genomics 19: 129138.
  • Muller J, Lips KS, Metzner L, Neubert RH, Koepsell H, Brandsch M (2005). Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem Pharmacol 70: 18511860.
  • Muto M, Onogawa T, Suzuki T, Ishida T, Rikiyama T, Katayose Y et al. (2007). Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma. Cancer Sci 98: 15701576.
  • Mwinyi J, Johne A, Bauer S, Roots I, Gerloff T (2004). Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics. Clin Pharmacol Ther 75: 415421.
  • Nakagomi-Hagihara R, Nakai D, Kawai K, Yoshigae Y, Tokui T, Abe T et al. (2006). OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker. Drug Metab Dispos 34: 862869.
  • Nakai D, Nakagomi R, Furuta Y, Tokui T, Abe T, Ikeda T et al. (2001). Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes. J Pharmacol Exp Ther 297: 861867.
  • Nakakariya M, Shimada T, Irokawa M, Maeda T, Tamai I (2008). Identification and species similarity of OATP transporters responsible for hepatic uptake of beta-lactam antibiotics. Drug Metab Pharmacokinet 23: 347355.
  • Neuvonen PJ, Niemi M, Backman JT (2006). Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. Clin Pharmacol Ther 80: 565581.
  • Niemi M, Schaeffeler E, Lang T, Fromm MF, Neuvonen M, Kyrklund C et al. (2004). High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1). Pharmacogenetics 14: 429440.
  • Nies AT, Herrmann E, Brom M, Keppler D (2008). Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Naunyn Schmiedebergs Arch Pharmacol 376: 449461.
  • Nies AT, Koepsell H, Winter S, Burk O, Klein K, Kerb R et al. (2009). Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology 50: 12271240.
  • Nies AT, Koepsell H, Damme K, Schwab M (2011). Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy. Handb Exp Pharmacol 201: 105167.
  • Nigam SK, Bush KT, Bhatnagar V (2007). Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol 3: 443448.
  • Nishimura T, Kubo Y, Kato Y, Sai Y, Ogihara T, Tsuji A (2007). Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells: involvement of organic anion transporting polypeptide (OATP)-B. Pharm Res 24: 9098.
  • Nishiwaki T, Daigo Y, Tamari M, Fujii Y, Nakamura Y (1998). Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters. Cytogenet Cell Genet 83: 251255.
  • Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T et al. (2003). Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. Clin Pharmacol Ther 73: 554565.
  • Noe J, Portmann R, Brun ME, Funk C (2007). Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug Metab Dispos 35: 13081314.
  • Nomura T, Lu R, Pucci ML, Schuster VL (2004). The two-step model of prostaglandin signal termination: in vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase. Mol Pharmacol 65: 973978.
  • Nomura T, Chang HY, Lu R, Hankin J, Murphy RC, Schuster VL (2005). Prostaglandin signaling in the renal collecting duct: release, reuptake, and oxidation in the same cell. J Biol Chem 280: 2842428429.
  • Nozaki Y, Kusuhara H, Kondo T, Iwaki M, Shiroyanagi Y, Nakayama H et al. (2007). Species difference in the inhibitory effect of nonsteroidal anti-inflammatory drugs on the uptake of methotrexate by human kidney slices. J Pharmacol Exp Ther 322: 11621170.
  • Nozawa T, Tamai I, Sai Y, Nezu J, Tsuji A (2003). Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin. J Pharm Pharmacol 55: 10131020.
  • Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I (2004a). Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther 308: 438445.
  • Nozawa T, Sugiura S, Nakajima M, Goto A, Yokoi T, Nezu J et al. (2004b). Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity. Drug Metab Dispos 32: 291294.
  • Nozawa T, Minami H, Sugiura S, Tsuji A, Tamai I (2005). Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms. Drug Metab Dispos 33: 434439.
  • Obaidat A, Roth M, Hagenbuch B (2012). The expression and function of organic anion transporting polypeptides in cancer. Annu Rev Pharmacol Toxicol 52: 135151.
  • Oostendorp RL, van de Steeg E, van der Kruijssen CM, Beijnen JH, Kenworthy KE, Schinkel AH et al. (2009). Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors. Drug Metab Dispos 37: 917923.
  • Oswald M, Kullak-Ublick GA, Paumgartner G, Beuers U (2001). Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis. Liver 21: 247253.
  • Oswald S, Konig J, Lutjohann D, Giessmann T, Kroemer HK, Rimmbach C et al. (2008). Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1. Pharmacogenet Genomics 18: 559568.
  • Pacyniak E, Roth M, Hagenbuch B, Guo GL (2010). Mechanism of polybrominated diphenyl ether uptake into the liver: PBDE congeners are substrates of human hepatic OATP transporters. Toxicol Sci 115: 344353.
  • Pasanen MK, Neuvonen M, Neuvonen PJ, Niemi M (2006). SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid. Pharmacogenet Genomics 16: 873879.
  • Pascolo L, Cupelli F, Anelli PL, Lorusso V, Visigalli M, Uggeri F et al. (1999). Molecular mechanisms for the hepatic uptake of magnetic resonance imaging contrast agents. Biochem Biophys Res Commun 257: 746752.
  • Perry JL, Dembla-Rajpal N, Hall LA, Pritchard JB (2006). A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport. J Biol Chem 281: 3807138079.
  • Picard N, Yee SW, Woillard JB, Lebranchu Y, Le Meur Y, Giacomini KM et al. (2010). The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics. Clin Pharmacol Ther 87: 100108.
  • Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ (2002). Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol 16: 22832296.
  • Pizzagalli F, Varga Z, Huber RD, Folkers G, Meier PJ, St-Pierre MV (2003). Identification of steroid sulfate transport processes in the human mammary gland. J Clin Endocrinol Metab 88: 39023912.
  • Plaza F, Gabler F, Romero C, Vantman D, Valladares L, Vega M (2010). The conversion of dehydroepiandrosterone into androst-5-ene-3beta,17beta-diol (androstenediol) is increased in endometria from untreated women with polycystic ovarian syndrome. Steroids 75: 810817.
  • Popowski K, Eloranta JJ, Saborowski M, Fried M, Meier PJ, Kullak-Ublick GA (2005). The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids. Mol Pharmacol 67: 16291638.
  • Popp C, Gorboulev V, Muller TD, Gorbunov D, Shatskaya N, Koepsell H (2005). Amino acids critical for substrate affinity of rat organic cation transporter 1 line the substrate binding region in a model derived from the tertiary structure of lactose permease. Mol Pharmacol 67: 16001611.
  • Price KL, Sautin YY, Long DA, Zhang L, Miyazaki H, Mu W et al. (2006). Human vascular smooth muscle cells express a urate transporter. J Am Soc Nephrol 17: 17911795.
  • Pritchard JB, Sweet DH, Miller DS, Walden R (1999). Mechanism of organic anion transport across the apical membrane of choroid plexus. J Biol Chem 274: 3338233387.
  • Race JE, Grassl SM, Williams WJ, Holtzman EJ (1999). Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun 255: 508514.
  • Reid G, Wolff NA, Dautzenberg FM, Burckhardt G (1998). Cloning of a human renal p-aminohippurate transporter, hROAT1. Kidney Blood Press Res 21: 233237.
  • Rizwan AN, Krick W, Burckhardt G (2007). The chloride dependence of the human organic anion transporter 1 (hOAT1) is blunted by mutation of a single amino acid. J Biol Chem 282: 1340213409.
  • Roberts LM, Woodford K, Zhou M, Black DS, Haggerty JE, Tate EH et al. (2008). Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier. Endocrinology 149: 62516261.
  • Roth M, Araya JJ, Timmermann BN, Hagenbuch B (2011a). Isolation of modulators of the liver specific Organic Anion Transporting Polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae). J Pharmacol Exp Ther 339: 624632.
  • Roth M, Timmermann BN, Hagenbuch B (2011b). Interactions of green tea catechins with organic anion-transporting polypeptides. Drug Metab Dispos 39: 920926.
  • Saborowski M, Kullak-Ublick GA, Eloranta JJ (2006). The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha. J Pharmacol Exp Ther 317: 778785.
  • Sai Y, Kaneko Y, Ito S, Mitsuoka K, Kato Y, Tamai I et al. (2006). Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells. Drug Metab Dispos 34: 14231431.
  • Saji T, Kikuchi R, Kusuhara H, Kim I, Gonzalez FJ, Sugiyama Y (2008). Transcriptional regulation of human and mouse organic anion transporter 1 by hepatocyte nuclear factor 1 alpha/beta. J Pharmacol Exp Ther 324: 784790.
  • Sakamoto S, Kusuhara H, Horie K, Takahashi K, Baba T, Ishizaki J et al. (2008). Identification of the transporters involved in the hepatobiliary transport and intestinal efflux of methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-na phthoate (S-8921) glucuronide, a pharmacologically active metabolite of S-8921. Drug Metab Dispos 36: 15531561.
  • Sakata T, Anzai N, Kimura T, Miura D, Fukutomi T, Takeda M et al. (2010). Functional analysis of human organic cation transporter OCT3 (SLC22A3) polymorphisms. J Pharmacol Sci 113: 263266.
  • Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA et al. (2005). Hepatic uptake of the novel antifungal agent caspofungin. Drug Metab Dispos 33: 676682.
  • Sasaki M, Suzuki H, Ito K, Abe T, Sugiyama Y (2002). Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2). J Biol Chem 277: 64976503.
  • Sata R, Ohtani H, Tsujimoto M, Murakami H, Koyabu N, Nakamura T et al. (2005). Functional analysis of organic cation transporter 3 expressed in human placenta. J Pharmacol Exp Ther 315: 888895.
  • Satlin LM, Amin V, Wolkoff AW (1997). Organic anion transporting polypeptide mediates organic anion/HCO3- exchange. J Biol Chem 272: 2634026345.
  • Sato K, Sugawara J, Sato T, Mizutamari H, Suzuki T, Ito A et al. (2003). Expression of Organic Anion Transporting Polypeptide E (OATP-E) in human placenta. Placenta 24: 144148.
  • Satoh H, Yamashita F, Tsujimoto M, Murakami H, Koyabu N, Ohtani H et al. (2005). Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos 33: 518523.
  • Sauvant C, Holzinger H, Gekle M (2001). Modulation of the basolateral and apical step of transepithelial organic anion secretion in proximal tubular opossum kidney cells. Acute effects of epidermal growth factor and mitogen-activated protein kinase. J Biol Chem 276: 1469514703.
  • Sauvant C, Holzinger H, Gekle M (2002). Short-term regulation of basolateral organic anion uptake in proximal tubular OK cells: EGF acts via MAPK, PLA(2), and COX1. J Am Soc Nephrol 13: 19811991.
  • Sauvant C, Holzinger H, Gekle M (2006). Prostaglandin E2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3. J Am Soc Nephrol 17: 4653.
  • Schiffer R, Neis M, Holler D, Rodriguez F, Geier A, Gartung C et al. (2003). Active influx transport is mediated by members of the organic anion transporting polypeptide family in human epidermal keratinocytes. J Invest Dermatol 120: 285291.
  • Schuster VL (2002). Prostaglandin transport. Prostaglandins Other Lipid Mediat 68–69: 633647.
  • Seithel A, Eberl S, Singer K, Auge D, Heinkele G, Wolf NB et al. (2007). The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3. Drug Metab Dispos 35: 779786.
  • Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y et al. (1998). Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett 429: 179182.
  • Seth P, Wu X, Huang W, Leibach FH, Ganapathy V (1999). Mutations in novel organic cation transporter (OCTN2), an organic cation/carnitine transporter, with differential effects on the organic cation transport function and the carnitine transport function. J Biol Chem 274: 3338833392.
  • Shimizu M, Fuse K, Okudaira K, Nishigaki R, Maeda K, Kusuhara H et al. (2005). Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans. Drug Metab Dispos 33: 14771481.
  • Shin HJ, Anzai N, Enomoto A, He X, Kim K, Endou H et al. (2007). Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. Hepatology 45: 10461055.
  • Shirasaka Y, Kuraoka E, Spahn-Langguth H, Nakanishi T, Langguth P, Tamai I (2010). Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. J Pharmacol Exp Ther 332: 181189.
  • Shitara Y, Itoh T, Sato H, Li AP, Sugiyama Y (2003). Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A. J Pharmacol Exp Ther 304: 610616.
  • Shu Y, Bello CL, Mangravite LM, Feng B, Giacomini KM (2001). Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells. J Pharmacol Exp Ther 299: 392398.
  • Smith NF, Acharya MR, Desai N, Figg WD, Sparreboom A (2005). Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel. Cancer Biol Ther 4: 815818.
  • Srimaroeng C, Perry JL, Pritchard JB (2008). Physiology, structure, and regulation of the cloned organic anion transporters. Xenobiotica 38: 889935.
  • Steckelbroeck S, Nassen A, Ugele B, Ludwig M, Watzka M, Reissinger A et al. (2004). Steroid sulfatase (STS) expression in the human temporal lobe: enzyme activity, mRNA expression and immunohistochemistry study. J Neurochem 89: 403417.
  • St-Pierre MV, Hagenbuch B, Ugele B, Meier PJ, Stallmach T (2002). Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta. J Clin Endocrinol Metab 87: 18561863.
  • Su Y, Zhang X, Sinko PJ (2004). Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. Mol Pharm 1: 4956.
  • Sun W, Wu RR, van Poelje PD, Erion MD (2001). Isolation of a family of organic anion transporters from human liver and kidney. Biochem Biophys Res Commun 283: 417422.
  • Suzuki T, Onogawa T, Asano N, Mizutamari H, Mikkaichi T, Tanemoto M et al. (2003). Identification and characterization of novel rat and human gonad specific organic anion transporters. Mol Endocrinol 17: 12031215.
  • Sweet DH, Wolff NA, Pritchard JB (1997). Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J Biol Chem 272: 3008830095.
  • Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam SK (2002). Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem 277: 2693426943.
  • Sykes D, Sweet DH, Lowes S, Nigam SK, Pritchard JB, Miller DS (2004). Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice. Am J Physiol Renal Physiol 286: F972F978.
  • Tachibana-Iimori R, Tabara Y, Kusuhara H, Kohara K, Kawamoto R, Nakura J et al. (2004). Effect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitors. Drug Metab Pharmacokinet 19: 375380.
  • Takada T, Weiss HM, Kretz O, Gross G, Sugiyama Y (2004). Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154. Drug Metab Dispos 32: 12721278.
  • Takeda M, Noshiro R, Onozato ML, Tojo A, Hasannejad H, Huang XL et al. (2004). Evidence for a role of human organic anion transporters in the muscular side effects of HMG-CoA reductase inhibitors. Eur J Pharmacol 483: 133138.
  • Takeuchi K, Sugiura T, Umeda S, Matsubara K, Horikawa M, Nakamichi N et al. (2011). Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent. Drug Metab Dispos 39: 10881096.
  • Tamai I, Yabuuchi H, Nezu J, Sai Y, Oku A, Shimane M et al. (1997). Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 419: 107111.
  • Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M et al. (2000). Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun 273: 251260.
  • Tamai I, Nozawa T, Koshida M, Nezu J, Sai Y, Tsuji A (2001). Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. Pharm Res 18: 12621269.
  • Tirona RG, Leake BF, Wolkoff AW, Kim RB (2003). Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther 304: 223228.
  • Tokuhiro S, Yamada R, Chang X, Suzuki A, Kochi Y, Sawada T et al. (2003). An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet 35: 341348.
  • Treiber A, Schneiter R, Hausler S, Stieger B (2007). Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil. Drug Metab Dispos 35: 14001407.
  • Tsigelny IF, Kovalskyy D, Kouznetsova VL, Balinskyi O, Sharikov Y, Bhatnagar V et al. (2011). Conformational changes of the multispecific transporter Organic Anion Transporter 1 (OAT1/SLC22A6) suggests a molecular mechanism for initial stages of drug and metabolite transport. Cell Biochem Biophys 61: 251259.
  • Tsuda-Tsukimoto M, Maeda T, Iwanaga T, Kume T, Tamai I (2006). Characterization of hepatobiliary transport systems of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035. Pharm Res 23: 26462656.
  • Ugele B, St-Pierre MV, Pihusch M, Bahn A, Hantschmann P (2003). Characterization and identification of steroid sulfate transporters of human placenta. Am J Physiol Endocrinol Metab 284: E390E398.
  • Urakami Y, Akazawa M, Saito H, Okuda M, Inui K (2002). cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol 13: 17031710.
  • Urban TJ, Sebro R, Hurowitz EH, Leabman MK, Badagnani I, Lagpacan LL et al. (2006). Functional genomics of membrane transporters in human populations. Genome Res 16: 223230.
  • Urban TJ, Yang C, Lagpacan LL, Brown C, Castro RA, Taylor TR et al. (2007). Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4). Pharmacogenet Genomics 17: 773782.
  • Vaidyanathan S, Camenisch G, Schuetz H, Reynolds C, Yeh CM, Bizot MN et al. (2008). Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren. J Clin Pharmacol 48: 13231338.
  • VanWert AL, Gionfriddo MR, Sweet DH (2010). Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology. Biopharm Drug Dispos 31: 171.
  • Varma MV, Rotter CJ, Chupka J, Whalen KM, Duignan DB, Feng B et al. (2011). pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1. Mol Pharm 8: 13031313.
  • Vavricka SR, Van Montfoort J, Ha HR, Meier PJ, Fattinger K (2002). Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Hepatology 36: 164172.
  • Vavricka SR, Jung D, Fried M, Grutzner U, Meier PJ, Kullak-Ublick GA (2004). The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma. J Hepatol 40: 212218.
  • Volk C, Gorboulev V, Kotzsch A, Muller TD, Koepsell H (2009). Five amino acids in the innermost cavity of the substrate binding cleft of organic cation transporter 1 interact with extracellular and intracellular corticosterone. Mol Pharmacol 76: 275289.
  • Vormfelde SV, Toliat MR, Schirmer M, Meineke I, Nurnberg P, Brockmoller J (2008). The polymorphisms Asn130Asp and Val174Ala in OATP1B1 and the CYP2C9 allele *3 independently affect torsemide pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther 83: 815817.
  • Walker AL, Franke RM, Sparreboom A, Ware RE (2011). Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol 39: 446456.
  • Wang P, Wang JJ, Xiao Y, Murray JW, Novikoff PM, Angeletti RH et al. (2005a). Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. J Biol Chem 280: 3014330149.
  • Wang P, Hata S, Xiao Y, Murray JW, Wolkoff AW (2008). Topological assessment of oatp1a1: a 12-transmembrane domain integral membrane protein with three N-linked carbohydrate chains. Am J Physiol Gastrointest Liver Physiol 294: G1052G1059.
  • Wang X, Wolkoff AW, Morris ME (2005b). Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators. Drug Metab Dispos 33: 16661672.
  • Weaver YM, Hagenbuch B (2010). Several conserved positively charged amino acids in OATP1B1 are involved in binding or translocation of different substrates. J Membr Biol 236: 279290.
  • Wen J, Xiong Y (2010). OATP1B1 388A>G polymorphism and pharmacokinetics of pitavastatin in Chinese healthy volunteers. J Clin Pharm Ther 35: 99104.
  • Werner D, Werner U, Meybaum A, Schmidt B, Umbreen S, Grosch A et al. (2008). Determinants of steady-state torasemide pharmacokinetics: impact of pharmacogenetic factors, gender and angiotensin II receptor blockers. Clin Pharmacokinet 47: 323332.
  • Wlcek K, Svoboda M, Riha J, Zakaria S, Olszewski U, Dvorak Z et al. (2011). The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer. Cancer Biol Ther 11: 801811.
  • Wojtal KA, Eloranta JJ, Hruz P, Gutmann H, Drewe J, Staumann A et al. (2009). Changes in mRNA expression levels of solute carrier transporters in inflammatory bowel disease patients. Drug Metab Dispos 37: 18711877.
  • Wolff NA, Thies K, Kuhnke N, Reid G, Friedrich B, Lang F et al. (2003). Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization. J Am Soc Nephrol 14: 19591968.
  • Wood M, Ananthanarayanan M, Jones B, Wooton-Kee R, Hoffman T, Suchy FJ et al. (2005). Hormonal regulation of hepatic organic anion transporting polypeptides. Mol Pharmacol 68: 218225.
  • Wu X, Prasad PD, Leibach FH, Ganapathy V (1998). cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun 246: 589595.
  • Wu X, Huang W, Ganapathy ME, Wang H, Kekuda R, Conway SJ et al. (2000). Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol 279: F449F458.
  • Yamada A, Maeda K, Kamiyama E, Sugiyama D, Kondo T, Shiroyanagi Y et al. (2007). Multiple human isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-receptor. Drug Metab Dispos 35: 21662176.
  • Yamaguchi H, Okada M, Akitaya S, Ohara H, Mikkaichi T, Ishikawa H et al. (2006). Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3. J Lipid Res 47: 11961202.
  • Yamaguchi H, Sugie M, Okada M, Mikkaichi T, Toyohara T, Abe T et al. (2010). Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1. Drug Metab Pharmacokinet 25: 314317.
  • Yamakawa Y, Hamada A, Shuto T, Yuki M, Uchida T, Kai H et al. (2011). Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia. Clin Pharmacol Ther 90: 157163.
  • Yamashiro W, Maeda K, Hirouchi M, Adachi Y, Hu Z, Sugiyama Y (2006). Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans. Drug Metab Dispos 34: 12471254.
  • Youngblood GL, Sweet DH (2004). Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Am J Physiol Renal Physiol 287: F236F244.
  • Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM (1997). Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol 51: 913921.
  • Zhang Q, Hong M, Duan P, Pan Z, Ma J, You G (2008). Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathway. J Biol Chem 283: 3257032579.
  • Zhang W, He YJ, Han CT, Liu ZQ, Li Q, Fan L et al. (2006). Effect of SLCO1B1 genetic polymorphism on the pharmacokinetics of nateglinide. Br J Clin Pharmacol 62: 567572.
  • Zhou F, Zhu L, Cui PH, Church WB, Murray M (2010). Functional characterization of nonsynonymous single nucleotide polymorphisms in the human organic anion transporter 4 (hOAT4). Br J Pharmacol 159: 419427.
  • Zwart R, Verhaagh S, Buitelaar M, Popp-Snijders C, Barlow DP (2001). Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3/Slc22a3-deficient mice. Mol Cell Biol 21: 41884196.