Double blockade of angiotensin II (AT1)-receptors and ACE does not improve weight gain and glucose homeostasis better than single-drug treatments in obese rats
Article first published online: 23 MAR 2012
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society
British Journal of Pharmacology
Special Issue: Themed Section: Cannabinoids in Biology and Medicine, Part II. Guest Editors: Itai Bab and Steve Alexander
Volume 165, Issue 8, pages 2721–2735, April 2012
How to Cite
Miesel, A., Müller-Fielitz, H., Jöhren, O., Vogt, F. M. and Raasch, W. (2012), Double blockade of angiotensin II (AT1)-receptors and ACE does not improve weight gain and glucose homeostasis better than single-drug treatments in obese rats. British Journal of Pharmacology, 165: 2721–2735. doi: 10.1111/j.1476-5381.2011.01726.x
- Issue published online: 23 MAR 2012
- Article first published online: 23 MAR 2012
- Accepted manuscript online: 20 OCT 2011 10:24AM EST
- Received; 26 June 2011; Revised; 30 August 2011; Accepted; 26 September 2011
Figure S1 Absolute weekly energy intake of SHR. SHR were allowed to freely choose between a cafeteria diet (various commercial chocolate and cookie bars which were daily changed) and a standard chow. Rats were simultaneously treated for 12 weeks with telmisartan (8 mg·kgbw−1·day−1), ramipril (4 mg·kgbw−1·day−1), telmisartan + ramipril (8 + 4 mg·kgbw−1·day−1) or water (controls) respectively. Means ± SEM, n = 12–14; *P < 0.05 versus CON.
Figure S2 (A) Baseline plasma concentrations of corticosterone did not differ during the treatment time of 12 weeks in rats that were treated with telmisartan (8 mg·kgbw−1·day−1), ramipril (4 mg·kgbw−1·day−1), telmisartan + ramipril (8 + 4 mg·kgbw−1·day−1) or water (controls). (B) Energy intake of rats one day before and 1 day after the stress test. The open bars represent the intake of chow, and the grey shaded bars represent the CD intake. Means ± SEM, n = 12–14; *P < 0.05 versus. before stress.
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