Secretin family (Class B) G protein-coupled receptors – from molecular to clinical perspectives


  • David R Poyner. David Poyner is a molecular pharmacologist with a long-term interest in GPCRs. While initially working on muscarinic receptors, for the last 20 years he has studied the molecular pharmacology of CGRP.

  • Debbie L Hay. Debbie Hay is a molecular pharmacologist, specialising in structure-function studies of family B GPCRs. In particular, her work focuses on the receptors for the CGRP/adrenomedullin/amylin/calcitonin family of peptides. These receptors are postulated to be good drug targets for a range of conditions including migraine, cardiovascular disease, cancer and diabetes.

Debbie L Hay, School of Biological Sciences, Thomas Building, 3A Symonds Street, University of Auckland, Private Bag 92019, Auckland, New Zealand. E-mail:


Family B G protein-coupled receptors represent an important but under-researched group of receptors. This edition of the British Journal of Pharmacology considers the roles and pharmacology of a number of these receptors. Whilst common themes emerge, it is clear that more work is needed to understand the details of each receptor in order to properly exploit them therapeutically.

LINKED ARTICLES This article is part of a themed section on Secretin Family (Class B) G Protein-Coupled Receptors. To view the other articles in this section visit