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Access of inhibitory neurosteroids to the NMDA receptor
Article first published online: 8 MAY 2012
DOI: 10.1111/j.1476-5381.2011.01816.x
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society
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How to Cite
Borovska, J., Vyklicky, V., Stastna, E., Kapras, V., Slavikova, B., Horak, M., Chodounska, H. and Vyklicky Jr, L. (2012), Access of inhibitory neurosteroids to the NMDA receptor. British Journal of Pharmacology, 166: 1069–1083. doi: 10.1111/j.1476-5381.2011.01816.x
Publication History
- Issue published online: 8 MAY 2012
- Article first published online: 8 MAY 2012
- Accepted manuscript online: 20 DEC 2011 12:35PM EST
- Received; 22 July 2011; Revised; 25 November 2011; Accepted; 12 December 2011
- Abstract
- Article
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Figure S1 Correlation between inhibitory effects of steroid analogues and their structure. Shown is a scatter plot of data for sixteen C3-substituted steroid analogues (see Figure 1 for their structure). The ordinate gives the IC50 for inhibition (see Table 1), and the abscissa shows the distance between the charged moiety and the C3 of the steroid skeleton (distance) (see Methods for details). The solid line shows the regression of IC50 on distance (correlation coefficient r = 0.60). Inset shows an example of a 3D structure of PA-25 as determined from 3D modelling (see Methods).
| Filename | Format | Size | Description |
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| BPH_1816_sm_FigureS1.tif | 1340K | Supporting info item | |
| BPH_1816_sm_Legend.doc | 581K | Supporting info item |
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