Access of inhibitory neurosteroids to the NMDA receptor
Article first published online: 8 MAY 2012
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society
British Journal of Pharmacology
Volume 166, Issue 3, pages 1069–1083, June 2012
How to Cite
Borovska, J., Vyklicky, V., Stastna, E., Kapras, V., Slavikova, B., Horak, M., Chodounska, H. and Vyklicky Jr, L. (2012), Access of inhibitory neurosteroids to the NMDA receptor. British Journal of Pharmacology, 166: 1069–1083. doi: 10.1111/j.1476-5381.2011.01816.x
- Issue published online: 8 MAY 2012
- Article first published online: 8 MAY 2012
- Accepted manuscript online: 20 DEC 2011 12:35PM EST
- Received; 22 July 2011; Revised; 25 November 2011; Accepted; 12 December 2011
Figure S1 Correlation between inhibitory effects of steroid analogues and their structure. Shown is a scatter plot of data for sixteen C3-substituted steroid analogues (see Figure 1 for their structure). The ordinate gives the IC50 for inhibition (see Table 1), and the abscissa shows the distance between the charged moiety and the C3 of the steroid skeleton (distance) (see Methods for details). The solid line shows the regression of IC50 on distance (correlation coefficient r = 0.60). Inset shows an example of a 3D structure of PA-25 as determined from 3D modelling (see Methods).
|BPH_1816_sm_FigureS1.tif||1340K||Supporting info item|
|BPH_1816_sm_Legend.doc||581K||Supporting info item|
Please note: Wiley-Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.