Sphingosine kinase: a key to solving the ‘French Paradox’?

Authors

  • Jeremy A Hengst,

    1. Department of Pharmacology, Pennsylvania State Hershey College of Medicine, Hershey, PA, USA
    Search for more papers by this author
  • Jong K Yun

    Corresponding author
    1. Department of Pharmacology, Pennsylvania State Hershey College of Medicine, Hershey, PA, USA
      Jong K Yun, Department of Pharmacology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033-0850, USA. E-mail: jky1@psu.edu
    Search for more papers by this author

Jong K Yun, Department of Pharmacology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033-0850, USA. E-mail: jky1@psu.edu

Abstract

A host of beneficial effects have been attributed to the red wine polyphenol, resveratrol. Foremost, among these are its anti-cancer properties. Yet, the mechanism by which resveratrol achieves these effects are unknown. In this issueof the BJP, Lim et al. report that resveratrol and its higher order oligomers inhibit sphingosine kinase 1 (SphK1). SphK1 is a key regulator of sphingolipid metabolism and alterations of this key metabolic pathway have been linked to many hyperproliferative diseases. This study identifies a target for the action of resveratrol and its higher order oligomers and opens the door to evaluation of SphK1 as a target for chemo-prevention of cancer.

LINKED ARTICLE

This article is a commentary on Lim et al., pp. 1605–1616 of this issue. To view this paper visit http://dx.doi.org/10.1111/j.1476-5381.2012.01862.x

Ancillary