Sphingosine kinase: a key to solving the ‘French Paradox’?
Article first published online: 21 JUN 2012
© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society
British Journal of Pharmacology
Volume 166, Issue 5, pages 1603–1604, July 2012
How to Cite
Hengst, J. A. and Yun, J. K. (2012), Sphingosine kinase: a key to solving the ‘French Paradox’?. British Journal of Pharmacology, 166: 1603–1604. doi: 10.1111/j.1476-5381.2012.01898.x
- Issue published online: 21 JUN 2012
- Article first published online: 21 JUN 2012
- Accepted manuscript online: 15 FEB 2012 11:44AM EST
- Received; 26 January 2012; Accepted; 8 February 2012
- sphingosine kinase;
A host of beneficial effects have been attributed to the red wine polyphenol, resveratrol. Foremost, among these are its anti-cancer properties. Yet, the mechanism by which resveratrol achieves these effects are unknown. In this issueof the BJP, Lim et al. report that resveratrol and its higher order oligomers inhibit sphingosine kinase 1 (SphK1). SphK1 is a key regulator of sphingolipid metabolism and alterations of this key metabolic pathway have been linked to many hyperproliferative diseases. This study identifies a target for the action of resveratrol and its higher order oligomers and opens the door to evaluation of SphK1 as a target for chemo-prevention of cancer.
This article is a commentary on Lim et al., pp. 1605–1616 of this issue. To view this paper visit http://dx.doi.org/10.1111/j.1476-5381.2012.01862.x