Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans
Article first published online: 24 JUL 2012
© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society
British Journal of Pharmacology
Volume 166, Issue 8, pages 2277–2288, August 2012
How to Cite
Hysek, C., Schmid, Y., Rickli, A., Simmler, L., Donzelli, M., Grouzmann, E. and Liechti, M. (2012), Carvedilol inhibits the cardiostimulant and thermogenic effects of MDMA in humans. British Journal of Pharmacology, 166: 2277–2288. doi: 10.1111/j.1476-5381.2012.01936.x
- Issue published online: 24 JUL 2012
- Article first published online: 24 JUL 2012
- Accepted manuscript online: 8 MAR 2012 03:47AM EST
- Received; 16 December 2011; Revised; 6 February 2012; Accepted; 26 February 2012
- α- and β-adrenoceptors
BACKGROUND AND PURPOSE The use of ±3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) is associated with cardiovascular complications and hyperthermia.
EXPERIMENTAL APPROACH We assessed the effects of the α1- and β-adrenoceptor antagonist carvedilol on the cardiostimulant, thermogenic and subjective responses to MDMA in 16 healthy subjects. Carvedilol (50 mg) or placebo was administered 1 h before MDMA (125 mg) or placebo using a randomized, double-blind, placebo-controlled, four-period crossover design.
KEY RESULTS Carvedilol reduced MDMA-induced elevations in blood pressure, heart rate and body temperature. Carvedilol did not affect the subjective effects of MDMA including MDMA-induced good drug effects, drug high, drug liking, stimulation or adverse effects. Carvedilol did not alter the plasma exposure to MDMA.
CONCLUSIONS AND IMPLICATIONS α1- and β-Adrenoceptors contribute to the cardiostimulant and thermogenic effects of MDMA in humans but not to its psychotropic effects. Carvedilol could be useful in the treatment of cardiovascular and hyperthermic complications associated with ecstasy use.