Mandarin Translations


To cite any of the articles below, please refer to the full article and not the DOI of this translations section. inline image

So what do we call GPR18 now? inline image

SPH Alexander

School of Biomedical Sciences, University of Nottingham Medical School, Nottingham, UK

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01731.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01731.x

Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells inline image

Douglas McHugh1, Jeremy Page1, Emily Dunn1 and Heather B Bradshaw1,2

1Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA, and2Kinsey Institute for the Study of Sex, Gender and Reproduction, Indiana University, Bloomington, IN, USA

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01497.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01497.x

Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats inline image

Martin A Sticht1, Jonathan Z Long2, Erin M Rock1, Cheryl L Limebeer1, Raphael Mechoulam3, Benjamin F Cravatt2 and Linda A Parker1

1Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, Canada,2The Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA, and3Institute of Drug Research, Medical Faculty, Hebrew University, Jerusalem, Israel

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Compartmentalization of endocannabinoids into lipid rafts in a microglial cell line devoid of caveolin-1 inline image

Neta Rimmerman1, Heather B Bradshaw2, Ewa Kozela3, Rivka Levy1, Ana Juknat3 and Zvi Vogel3

1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel,2Psychological and brain sciences, Indiana University, Bloomington, IN, USA, and3Department of Physiology and Pharmacology, Sakler School of Medicine, the Dr Miriam and Sheldon G. Adelson Center for the Biology of Addictive Diseases, Tel Aviv University, Ramat Aviv, Israel

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01380.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01380.x

Δ8-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors inline image

Sándor Bátkai1, Partha Mukhopadhyay1, Bėla Horváth1,6, Mohanraj Rajesh1, Rachel Y Gao1, Anu Mahadevan2, Mukkanti Amere2, Natalia Battista3, Aron H Lichtman4, Lisa A Gauson5, Mauro Maccarrone3, Roger G Pertwee5 and Pál Pacher1

1Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA,2Organix Inc., Woburn, MA, USA,3Department of Biomedical Sciences, University of Teramo, Teramo, Italy, & European Center for Brain Research (CERC)/Santa Lucia Foundation, Rome, Italy,4The Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA,5School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK, and6Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01410.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01410.x

A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury inline image

Bėla Horváth1,5, Lital Magid3, Partha Mukhopadhyay1, Sándor Bátkai1, Mohanraj Rajesh1 Ogyi Park2 Galin, Tanchian1, Rachel Y Gao1, Catherine E Goodfellow4, Michelle Glass4, Raphael Mechoulam2 and Pál Pacher1

1Laboratory of Physiologic Studies and2Liver Disease, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA,3Institute of Drug Research, Faculty of Medicine, Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel,4Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, and5Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01381.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01381.x

The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABAA receptors inline image

R Baur, J Gertsch and E Sigel

Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstr, Bern, Switzerland

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01405.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01405.x

The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice inline image

Lamont Booker1, Steven G Kinsey1, Rehab A Abdullah1, Jacqueline L Blankman2, Jonathan Z Long2, Cyrine Ezzili3, Dale L Boger3, Benjamin F Cravatt2 and Aron H Lichtman1,4

1Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA,2Department of Chemical Physiology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA,3Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA, and4Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01445.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01445.x

Cannabinoid CB1 receptors transactivate multiple receptor tyrosine kinases and regulate serine/threonine kinases to activate ERK in neuronal cells inline image

George D Dalton and Allyn C Howlett

Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01455.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01455.x

Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9-tetrahydrocannabinol in BV-2 microglial cells inline image

Ana Juknat1, Maciej Pietr2, Ewa Kozela1, Neta Rimmerman2, Rivka Levy2, Giovanni Coppola3, Daniel Geschwind3 and Zvi Vogel1,2

1The Dr. Miriam and Sheldon G. Adelson Center for the Biology of Addictive Diseases, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel,2Neurobiology Department, Weizmann Institute of Science, Rehovot, Israel, and3Program in Neurogenetics, Department of Neurology, University of California, Los Angeles, CA, USA

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01461.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01461.x

Combined effects of THC and caffeine on working memory in rats inline image

Leigh V Panlilio1, Sergi Ferré1, Sevil Yasar2, Eric B Thorndike1, Charles W Schindler1 and Steven R Goldberg1

1Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA, and2Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01554.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01554.x

The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats inline image

Maria Scherma1,2, Zuzana Justinová1,3, Claudio Zanettini1, Leigh V Panlilio1, Paola Mascia1, Paola Fadda2, Walter Fratta2, Alexandros Makriyannis4, Subramanian K Vadivel4, Islam Gamaleddin5, Bernard Le Foll5,6 and Steven R Goldberg1

1Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA,2B.B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, Italy,3MPRC, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA,4Center for Drug Discovery, Northeastern University, Boston, MA, USA,5Translational Addiction Research Laboratory and Addiction Program, Centre for Addiction and Mental Health, Toronto, ON, Canada, and6Departments of Psychiatry, Pharmacology, Family and Community Medicine and Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01467.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01467.x

The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone inline image

WM Olango1,3,4, M Roche2,3,4, GK Ford1,3,4, B Harhen3,4 and DP Finn1,3,4

1Pharmacology and Therapeutics and2Physiology, School of Medicine,3NCBES Neuroscience Cluster and4Centre for Pain Research, National University of Ireland, Galway, Ireland

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01478.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01478.x

AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor inline image

Daniele Bolognini1,2, Maria Grazia Cascio1, Daniela Parolaro2 and Roger G Pertwee1

1Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK; and2DBSF, Pharmacology Section and Neuroscience Centre, University of Insubria, Varese, Italy

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Δ9-Tetrahydrocannabinol (Δ9-THC) attenuates mouse sperm motility and male fecundity inline image

Daniel J Morgan1,2, Charles H Muller3, Natalia A Murataeva1,2, Brian J Davis1,2 and Ken Mackie1,2

1Gill Center for Biomolecular Science, Indiana University, Bloomington, IN, USA,2Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA, and3Department of Urology, University of Washington School of Medicine, Seattle, WA, USA

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01506.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01506.x

Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitroinline image

LS Whyte, L Ford, SA Ridge, GA Cameron, MJ Rogers and RA Ross

Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01519.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01519.x

Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability inline image

A Alhamoruni1, KL Wright2, M Larvin1 and SE O'Sullivan1

1School of Graduate Entry Medicine & Health, Derby City General Hospital, University of Nottingham, Derby, UK, and2Division of Biomedical and Life Sciences, Faculty of Health & Medicine, Lancaster University, Lancashire, UK

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01589.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01589.x

The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55 inline image

J Kargl1, NA Balenga1, W Platzer1, L Martini, JL Whistler2 and M Waldhoer1

1Institute for Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria, and2Ernest Gallo Clinic and Research Center, University of California, San Francisco, CA, USA

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01562.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01562.x

Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus inline image

EM Rock1, D Bolognini2, CL Limebeer1, MG Cascio2, S Anavi-Goffer2, PJ Fletcher3, R Mechoulam4, RG Pertwee2 and LA Parker1

1Department of Psychology and Neuroscience Graduate Program, University of Guelph, Guelph, ON, Canada,2Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK,3Centre for Addiction and Mental Health and Department of Psychology, University of Toronto, Toronto, ON, Canada, and4Institute of Drug Research, Hebrew University Medical Faculty, Jerusalem, Israel

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01621.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01621.x

Effects of palmitoylation of Cys415 in helix 8 of the CB1 cannabinoid receptor on membrane localization and signalling inline image

Sergio Oddi1,2, Enrico Dainese1,2, Simone Sandiford3, Filomena Fezza2,4, Mirko Lanuti1,2, Valerio Chiurchiù2, Antonio Totaro2, Giuseppina Catanzaro1,2, Daniela Barcaroli5, Vincenzo De Laurenzi5, Diego Centonze2,6, Somnath Mukhopadhyay3, Jana Selent7, Allyn C Howlett8 and Mauro Maccarrone1,2

1Department of Biomedical Sciences, University of Teramo, Teramo, Italy,2European Center for Brain Research (CERC)/Santa Lucia Foundation I.R.C.C.S., Rome, Italy,3Neuroscience/Drug Abuse Research Program, Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, NC, USA,4Department of Experimental Medicine and Biochemical Sciences, University of Rome ‘Tor Vergata’, Rome, Italy,5Department of Biomedical Sciences, University of Chieti-Pescara ‘G. d'Annunzio’, Chieti, Italy,6Department of Neurosciences, University of Rome ‘Tor Vergata’, Rome, Italy,7Research Group of biomedical Informatics (GRIB-IMIM), University of Pompeu Fabra, Barcelona Biomedical Research Park (PRBB), Barcelona, Spain, and8Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, NC, USA

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The CB1 cannabinoid receptor C-terminus regulates receptor desensitization in autaptic hippocampal neurones inline image

Alex Straiker, Jim Wager-Miller and Ken Mackie

Department of Psychological and Brain Sciences, Gill Center for Biomolecular Science, Indiana University, Bloomington, IN, USA

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01743.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01743.x

Differential signalling in human cannabinoid CB1 receptors and their splice variants in autaptic hippocampal neurons inline image

Alex Straiker, Jim Wager-Miller, Jacqueline Hutchens and Ken Mackie

Department of Psychological and Brain Sciences, Gill Center for Biomolecular Science, Indiana University, Bloomington, IN, USA

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Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists inline image

David A Sykes and Steven J Charlton

Novartis Institutes for Biomedical Research, West Sussex, UK

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01639.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01639.x

Role of neurosteroids in the anticonvulsant activity of midazolam inline image

Ashish Dhir1 and Michael A Rogawski1,2

1Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA, and2Center for Neuroscience, University of California, Davis, Sacramento, CA, USA

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01733.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01733.x

Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet inline image

Xin-Hui Kou1, Mei-Feng Zhu2, Dai Chen2, Yi Lu1, Hui-Zhu Song1, Jian-Lin Ye1 and Lin-Feng Yue1

1Department of Pharmacy, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, China, and2Department of Nephrology, Changzhou Traditional Chinese Medical Hospital affiliated to Nanjing University of Traditional Chinese Medicine, Changzhou, China

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01727.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01727.x

Mechanism of action of the insecticides, lindane and fipronil, on glycine receptor chloride channels inline image

Robiul Islam1,2 and Joseph W Lynch1,2

1Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia, and2School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia

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Double blockade of angiotensin II (AT1)-receptors and ACE does not improve weight gain and glucose homeostasis better than single-drug treatments in obese rats inline image

Anja Miesel1, Helge Müller-Fielitz1, Olaf Jöhren1, Florian M Vogt2 and Walter Raasch1

1Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany, and2Clinic for Radiology and Nuclear Medicine, University of Lübeck, Lübeck, Germany

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01726.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01726.x

Glucagon and a glucagon-GLP-1 dual-agonist increases cardiac performance with different metabolic effects in insulin-resistant hearts inline image

LN Axelsen1,2,3, W Keung1, HD Pedersen2, E Meier2, D Riber2, AL Kjølbye2, JS Petersen2, SD Proctor4, N-H Holstein-Rathlou3 and GD Lopaschuk1

1Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, and Metabolic and Cardiovascular Diseases Laboratory, Edmonton, AB, Canada,2Zealand Pharma, Glostrup, Denmark,3The Danish National Research Foundation Centre for Cardiac Arrhythmia and Department of Biomedical Sciences, University of Copenhagen, Copenhagen N, Denmark, and4Alberta Institute for Human Nutrition, Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01714.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01714.x

S(+)amphetamine induces a persistent leak in the human dopamine transporter: molecular stent hypothesis inline image

Aldo A Rodriguez-Menchaca, Ernesto Solis Jr, Krasnodara Cameron and Louis J De Felice

Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA

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To view the full version of this article please visit http://dx.doi.org/10.1111/j.1476-5381.2011.01728.xinline imagehttp://dx.doi.org/10.1111/j.1476-5381.2011.01728.x

The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119 inline image

Virginia M Stone1, Shalinee Dhayal1, David M Smith2, Carol Lenaghan2, Katy J Brocklehurst2 and Noel G Morgan1

1Institute of Biomedical & Clinical Sciences, Peninsula Medical School, University of Exeter, Plymouth, Devon, UK, and2AstraZeneca Diabetes and Obesity Drug Discovery, Macclesfield, Cheshire, UK

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Investigation of mechanism of drug-induced cardiac injury and torsades de pointes in cynomolgus monkeys inline image

DL Misner1, C Frantz2, L Guo3, MR Gralinski4, PB Senese4, J Ly5, M Albassam3 and KL Kolaja3

1Celgene Corporation, San Diego, CA, USA,2Medimmune, Mountain View, CA, USA,3Hoffmann-La Roche, Nutley, NJ, USA,4CorDynamics Inc., Chicago, IL, USA, and5Genentech, South San Francisco, CA, USA

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Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates inline image

AM Filppula1, J Laitila1, PJ Neuvonen1,2 and JT Backman1,2

1Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland, and2HUSLAB, Helsinki University Central Hospital, Helsinki, Finland

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Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathways inline image

H Lan1, HV Lin1, CF Wang1, MJ Wright1, S Xu1, L Kang1, K Juhl1, JA Hedrick2 and TJ Kowalski1

1Diabetes and Endocrinology, Merck Research Laboratories, Rahway, NJ, USA, and2Biologics, Merck Research Laboratories, Rahway, NJ, USA

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Ancillary