Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation
Article first published online: 20 DEC 2012
© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society
British Journal of Pharmacology
Special Issue: Themed Section: Endothelin. Guest Editors: Anthony P Davenport and Matthias Barton
Volume 168, Issue 2, pages 421–431, January 2013
How to Cite
Oh, S. B., Park, H. R., Jang, Y. J., Choi, S. Y., Son, T. G. and Lee, J. (2013), Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation. British Journal of Pharmacology, 168: 421–431. doi: 10.1111/j.1476-5381.2012.02142.x
- Issue published online: 20 DEC 2012
- Article first published online: 20 DEC 2012
- Accepted manuscript online: 15 AUG 2012 01:15AM EST
- Manuscript Accepted: 7 AUG 2012
- Manuscript Revised: 18 JUL 2012
- Manuscript Received: 25 APR 2012
- Ministry of Education, Science and Technology. Grant Number: 2009–0067608
- Korea government (MEST). Grant Number: 20090083538
Figure S1 C17.2 NPCs exposed to irradiation showed a dose-dependent increase in cell death.
To evaluate cell death and viability in response to irradiation, nuclei were stained with Hoechst 33342 and PI, and visualized by fluorescence microscopy. Radiation doses were found to be dose-dependently related to numbers of PI-stained cells (dead cells). Scale bar = 100 μm.
Figure S2 Detrimental effects of WBI on NPC proliferation in the hippocampi of mice. At one day after WBI, significant dose-dependent decreases were observed in the numbers of newly generated cells. (A) Representative images showing the number of BrdU-positive cells in the dentate gyrus. (B) Numbers of newly generated cells in the SGZ significantly decreased at 24 h post-WBI. WBI substantially and dose-dependently reduced proliferating cell numbers at dose from 5 to 30 Gy. Values are the means ± SE (n = 3 mice per group). **P < 0.01 versus controls (anova using Fisher's PLSD procedure). Scale bar = 100 μm.
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