Contributed equally to this work.
Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities
Article first published online: 16 JAN 2013
© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society
British Journal of Pharmacology
Volume 168, Issue 3, pages 673–685, February 2013
How to Cite
Prudent, R., Vassal-Stermann, É., Nguyen, C.-H., Mollaret, M., Viallet, J., Desroches-Castan, A., Martinez, A., Barette, C., Pillet, C., Valdameri, G., Soleilhac, E., Di Pietro, A., Feige, J.-J., Billaud, M., Florent, J.-C. and Lafanechère, L. (2013), Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities. British Journal of Pharmacology, 168: 673–685. doi: 10.1111/j.1476-5381.2012.02230.x
- Issue published online: 16 JAN 2013
- Article first published online: 16 JAN 2013
- Accepted manuscript online: 25 SEP 2012 02:25AM EST
- Manuscript Accepted: 10 AUG 2012
- Manuscript Revised: 20 JUL 2012
- Manuscript Received: 11 APR 2012
- Centre National pour la Recherche Scientifique
- Commissariat à l'Energie atomique
- Institut Curie
- Alliance des Recherches sur le Cancer (an initiative of the Association pour la Recherche sur le Cancer)
- Rhône-Alpes Region
Figure S1 Reversibility of CM01 and CM02 effects in HeLa cells. HeLa cells were treated for 2 h with 0.25% DMSO (control); 5 μM colchicine; 10 μM nocodazole, 25 μM nocodazole, 25 μM CM01 or 25 μM CM02, as indicated. Compounds were the removed and cells were incubated overnight in fresh medium. They were then fixed and stained for α-tubulin.
Table S1 Flow chart of the automated screening of the library and the subsequent analysis of active compounds.
Appendix S1 Cell lines and culture.
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