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References

  • Alexander SPH, Mathie A, Peters JA (2011). Guide to Receptors and Channels (GRAC), 5th edition. Br J Pharmacol 164 (Suppl. 1): S1S324.
  • Asakura M, Kitakaze M, Takashima S, Liao Y, Ishikura F, Yoshinaka T et al. (2002). Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat Med 8: 3540.
  • Bennett VJ, Perrine SA, Simmons MA (2002). A novel mechanism of neurokinin-1 receptor resensitization. J Pharmacol Exp Ther 303: 11551162.
  • Bennett VJ, Perrine SA, Simmons MA (2005). Neurokinin-1 receptor resensitization precedes receptor recycling. J Pharmacol Exp Ther 313: 13471354.
  • Berthouze M, Venkataramanan V, Li Y, Shenoy SK (2009). The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. EMBO J 28: 16841696.
  • Blackhart BD, Ruslim-Litrus L, Lu CC, Alves VL, Teng W, Scarborough RM et al. (2000). Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide. Mol Pharmacol 58: 11781187.
  • Bohm SK, Kong W, Bromme D, Smeekens SP, Anderson DC, Connolly A et al. (1996). Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J 314 (Pt 3): 10091016.
  • Boire A, Covic L, Agarwal A, Jacques S, Sherifi S, Kuliopulos A (2005). PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 120: 303313.
  • Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I (1985). Calcitonin gene-related peptide is a potent vasodilator. Nature 313: 5456.
  • Bralet J, Marie C, Mossiat C, Lecomte JM, Gros C, Schwartz JC (1994). Effects of alatriopril, a mixed inhibitor of atriopeptidase and angiotensin I-converting enzyme, on cardiac hypertrophy and hormonal responses in rats with myocardial infarction. Comparison with captopril. J Pharmacol Exp Ther 270: 814.
  • Brun P, Mastrotto C, Beggiao E, Stefani A, Barzon L, Sturniolo GC et al. (2005). Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation. Am J Physiol Gastrointest Liver Physiol 288: G621G629.
  • Burger MM (1970). Proteolytic enzymes initiating cell division and escape from contact inhibition of growth. Nature 227: 170171.
  • Buteau J, Foisy S, Joly E, Prentki M (2003). Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor. Diabetes 52: 124132.
  • Cain CC, Sipe DM, Murphy RF (1989). Regulation of endocytic pH by the Na+,K+-ATPase in living cells. Proc Natl Acad Sci U S A 86: 544548.
  • Camerer E, Huang W, Coughlin SR (2000). Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci U S A 97: 52555260.
  • Canals M, Scholten DJ, de Munnik S, Han MK, Smit MJ, Leurs R (2012). Ubiquitination of CXCR7 controls receptor trafficking. PLoS ONE 7: e34192.
  • Carney DH, Cunningham DD (1977). Initiation of check cell division by trypsin action at the cell surface. Nature 268: 602606.
  • Carney DH, Cunningham DD (1978). Transmembrane action of thrombin initiates chick cell division. J Supramol Struct 9: 337350.
  • Castagliuolo I, Wang CC, Valenick L, Pasha A, Nikulasson S, Carraway RE et al. (1999). Neurotensin is a proinflammatory neuropeptide in colonic inflammation. J Clin Invest 103: 843849.
  • Castro-Obregon S, Rao RV, del Rio G, Chen SF, Poksay KS, Rabizadeh S et al. (2004). Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77. J Biol Chem 279: 1754317553.
  • Cattaruzza F, Cottrell GS, Vaksman N, Bunnett NW (2009). Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation. Br J Pharmacol 156: 730739.
  • Chen LB, Buchanan JM (1975). Mitogenic activity of blood components. I. Thrombin and prothrombin. Proc Natl Acad Sci U S A 72: 131135.
  • Cheng ZJ, Vapaatalo H, Mervaala E (2005). Angiotensin II and vascular inflammation. Med Sci Monit 11: RA194RA205.
  • CONSENSUS (1987). Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). The CONSENSUS Trial Study Group. N Engl J Med 316: 14291435.
  • Cottrell GS, Amadesi S, Grady EF, Bunnett NW (2004). Trypsin IV, a novel agonist of protease-activated receptors 2 and 4. J Biol Chem 279: 1353213539.
  • Cottrell GS, Padilla B, Pikios S, Roosterman D, Steinhoff M, Grady EF et al. (2007). Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1. J Biol Chem 282: 1226012271.
  • Cottrell GS, Padilla BE, Amadesi S, Poole DP, Murphy JE, Hardt M et al. (2009). Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. J Biol Chem 284: 2241122425.
  • Cumashi A, Ansuini H, Celli N, De Blasi A, O'Brien PJ, Brass LF et al. (2001). Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets. Thromb Haemost 85: 533538.
  • Daaka Y, Luttrell LM, Ahn S, Della Rocca GJ, Ferguson SS, Caron MG et al. (1998). Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J Biol Chem 273: 685688.
  • Daub H, Weiss FU, Wallasch C, Ullrich A (1996). Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379: 557560.
  • Daull P, Benrezzak O, Arsenault D, Pheng LH, Blouin A, Cayer J et al. (2005). Triple vasopeptidase inhibition normalizes blood pressure in conscious, unrestrained, and spontaneously hypertensive rats. Am J Hypertens 18 (12 Pt 1): 16061613.
  • Daull P, Blouin A, Belleville K, Beaudoin M, Arsenault D, Leonard H et al. (2006a). Triple VPI CGS 35601 reduces high blood pressure in low-renin, high-salt Dahl salt-sensitive rats. Exp Biol Med (Maywood) 231: 830833.
  • Daull P, Lepage R, Benrezzak O, Cayer J, Beaudoin M, Belleville K et al. (2006b). The first preclinical pharmacotoxicological safety assessment of CGS 35601, a triple vasopeptidase inhibitor, in chronically instrumented, conscious, and unrestrained spontaneously hypertensive rats. Drug Chem Toxicol 29: 183202.
  • DeFea KA, Zalevsky J, Thoma MS, Dery O, Mullins RD, Bunnett NW (2000). beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. J Cell Biol 148: 12671281.
  • Dery O, Defea KA, Bunnett NW (2001). Protein kinase C-mediated desensitization of the neurokinin 1 receptor. Am J Physiol Cell Physiol 280: C1097C1106.
  • Dive V, Chang CF, Yiotakis A, Sturrock ED (2009). Inhibition of zinc metallopeptidases in cardiovascular disease – from unity to trinity, or duality? Curr Pharm Des 15: 36063621.
  • Dulon S, Cande C, Bunnett NW, Hollenberg MD, Chignard M, Pidard D (2003). Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases. Am J Respir Cell Mol Biol 28: 339346.
  • Dulon S, Leduc D, Cottrell GS, D'Alayer J, Hansen KK, Bunnett NW et al. (2005). Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells. Am J Respir Cell Mol Biol 32: 411419.
  • Eguchi S, Inagami T (2000). Signal transduction of angiotensin II type 1 receptor through receptor tyrosine kinase. Regul Pept 91: 1320.
  • Eguchi S, Frank GD, Mifune M, Inagami T (2003). Metalloprotease-dependent ErbB ligand shedding in mediating EGFR transactivation and vascular remodelling. Biochem Soc Trans 31 (Pt 6): 11981202.
  • Feistritzer C, Riewald M (2005). Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood 105: 31783184.
  • Finigan JH, Dudek SM, Singleton PA, Chiang ET, Jacobson JR, Camp SM et al. (2005). Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation. J Biol Chem 280: 1728617293.
  • Forgac M, Cantley L, Wiedenmann B, Altstiel L, Branton D (1983). Clathrin-coated vesicles contain an ATP-dependent proton pump. Proc Natl Acad Sci U S A 80: 13001303.
  • Goh FG, Ng PY, Nilsson M, Kanke T, Plevin R (2009). Dual effect of the novel peptide antagonist K-14585 on proteinase-activated receptor-2-mediated signalling. Br J Pharmacol 158: 16951704.
  • Gooz P, Dang Y, Higashiyama S, Twal WO, Haycraft CJ, Gooz M (2012). A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by alpha5beta1 integrin in kidney mesangial cells. PLoS ONE 7: e33350.
  • Gros C, Noel N, Souque A, Schwartz JC, Danvy D, Plaquevent JC et al. (1991). Mixed inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) and enkephalinase (EC 3.4.24.11): rational design, properties, and potential cardiovascular applications of glycopril and alatriopril. Proc Natl Acad Sci U S A 88: 42104214.
  • Gross DM, Sweet CS, Ulm EH, Backlund EP, Morris AA, Weitz D et al. (1981). Effect of N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro and its ethyl ester (MK-421) on angiotensin converting enzyme in vitro and angiotensin I pressor responses in vivo. J Pharmacol Exp Ther 216: 552557.
  • Gschwind A, Hart S, Fischer OM, Ullrich A (2003). TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. EMBO J 22: 24112421.
  • Hammond-Martel I, Yu H, Affar B (2012). Roles of ubiquitin signaling in transcription regulation. Cell Signal 24: 410421.
  • Hart S, Fischer OM, Prenzel N, Zwick-Wallasch E, Schneider M, Hennighausen L et al. (2005). GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways. Biol Chem 386: 845855.
  • Hasdemir B, Murphy JE, Cottrell GS, Bunnett NW (2009). Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2. J Biol Chem 284: 2845328466.
  • Hasdemir B, Mahajan S, Bunnett NW, Liao M, Bhargava A (2012). Endothelin-converting enzyme-1 actions determine differential trafficking and signaling of corticotropin-releasing factor receptor 1 at high agonist concentrations. Mol Endocrinol 26: 681695.
  • Hicke L, Riezman H (1996). Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell 84: 277287.
  • Hilairet S, Belanger C, Bertrand J, Laperriere A, Foord SM, Bouvier M (2001). Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin. J Biol Chem 276: 4218242190.
  • Hislop JN, von Zastrow M (2011). Role of ubiquitination in endocytic trafficking of G-protein-coupled receptors. Traffic 12: 137148.
  • Hislop JN, Henry AG, Marchese A, von Zastrow M (2009). Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes. J Biol Chem 284: 1936119370.
  • Hislop JN, Henry AG, von Zastrow M (2011). Ubiquitination in the first cytoplasmic loop of mu-opioid receptors reveals a hierarchical mechanism of lysosomal down-regulation. J Biol Chem 286: 4019340204.
  • Huovila AP, Turner AJ, Pelto-Huikko M, Karkkainen I, Ortiz RM (2005). Shedding light on ADAM metalloproteinases. Trends Biochem Sci 30: 413422.
  • Ikeo T, Yabana H, Kurosawa H, Kaburaki M, Kikkawa K, Narita H et al. (1992). Acute hemodynamic effects of the active metabolite of imidapril, (4S)-3-((2S)-2-[N-((1S)-1-carboxy-3-phenyl-propyl)amino]propionyl)-1- methyl-2-oxoimidazolidine-4-carboxylic acid, and enalaprilat in anesthetized dogs. Arzneimittelforschung 42: 11091114.
  • Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C et al. (1997). Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 386: 502506.
  • Ishihara H, Zeng D, Connolly AJ, Tam C, Coughlin SR (1998). Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin. Blood 91: 41524157.
  • Itoh Y, Joh T, Tanida S, Sasaki M, Kataoka H, Itoh K et al. (2005). IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in human colon carcinoma cells. Cytokine 29: 275282.
  • Jacob C, Cottrell GS, Gehringer D, Schmidlin F, Grady EF, Bunnett NW (2005). c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. J Biol Chem 280: 1607616087.
  • Johnson GD, Stevenson T, Ahn K (1999). Hydrolysis of peptide hormones by endothelin-converting enzyme-1. A comparison with neprilysin. J Biol Chem 274: 40534058.
  • Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S et al. (1998). A dual thrombin receptor system for platelet activation. Nature 394: 690694.
  • Kawamura M, Kuraishi Y, Minami M, Satoh M (1989). Antinociceptive effect of intrathecally administered antiserum against calcitonin gene-related peptide on thermal and mechanical noxious stimuli in experimental hyperalgesic rats. Brain Res 497: 199203.
  • Kawasaki Y, Kohno T, Zhuang ZY, Brenner GJ, Wang H, Van Der Meer C et al. (2004). Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J Neurosci 24: 83108321.
  • Khimji AK, Rockey DC (2010). Endothelin – biology and disease. Cell Signal 22: 16151625.
  • Kuraishi Y, Nanayama T, Ohno H, Minami M, Satoh M (1988). Antinociception induced in rats by intrathecal administration of antiserum against calcitonin gene-related peptide. Neurosci Lett 92: 325329.
  • Kuwasako K, Shimekake Y, Masuda M, Nakahara K, Yoshida T, Kitaura M et al. (2000). Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling. J Biol Chem 275: 2960229609.
  • Lamberts SW, Bakker WH, Reubi JC, Krenning EP (1990). Somatostatin-receptor imaging in the localization of endocrine tumors. N Engl J Med 323: 12461249.
  • Law IK, Murphy JE, Bakirtzi K, Bunnett NW, Pothoulakis C (2012). Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by beta-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1. J Biol Chem 287: 1506615075.
  • Lee FS, Chao MV (2001). Activation of Trk neurotrophin receptors in the absence of neurotrophins. Proc Natl Acad Sci U S A 98: 35553560.
  • Li JG, Haines DS, Liu-Chen LY (2008). Agonist-promoted Lys63-linked polyubiquitination of the human kappa-opioid receptor is involved in receptor down-regulation. Mol Pharmacol 73: 13191330.
  • Linseman DA, Benjamin CW, Jones DA (1995). Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells. J Biol Chem 270: 1256312568.
  • Lundberg JM, Franco-Cereceda A, Hua X, Hokfelt T, Fischer JA (1985). Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin. Eur J Pharmacol 108: 315319.
  • Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ et al. (1999). Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283: 655661.
  • McDonald DM (1988). Neurogenic inflammation in the rat trachea. I. Changes in venules, leucocytes and epithelial cells. J Neurocytol 17: 583603.
  • McDonald DM, Mitchell RA, Gabella G, Haskell A (1988). Neurogenic inflammation in the rat trachea. II. Identity and distribution of nerves mediating the increase in vascular permeability. J Neurocytol 17: 605628.
  • McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N et al. (1998). RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393: 333339.
  • McLaughlin JN, Shen L, Holinstat M, Brooks JD, Dibenedetto E, Hamm HE (2005). Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. J Biol Chem 280: 2504825059.
  • McNeish AJ, Roux BT, Aylett S-B, Maassen Van Den Brink A, Cottrell GS (2012). Endosomal proteolysis regulates calcitonin gene-related peptide responses in mesenteric arteries. Br J Pharmacol 167: 16791690.
  • Malik R, Soh UJ, Trejo J, Marchese A (2012). Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. J Biol Chem 287: 90139027.
  • Malynn BA, Ma A (2010). Ubiquitin makes its mark on immune regulation. Immunity 33: 843852.
  • Mannaioni G, Orr AG, Hamill CE, Yuan H, Pedone KH, McCoy KL et al. (2008). Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1. J Biol Chem 283: 2060020611.
  • Mantyh PW, DeMaster E, Malhotra A, Ghilardi JR, Rogers SD, Mantyh CR et al. (1995). Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science 268: 16291632.
  • Marchese A, Benovic JL (2001). Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting. J Biol Chem 276: 4550945512.
  • Matsas R, Kenny AJ, Turner AJ (1984). The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11. Biochem J 223: 433440.
  • Maudsley S, Pierce KL, Zamah AM, Miller WE, Ahn S, Daaka Y et al. (2000). The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. J Biol Chem 275: 95729580.
  • Mifune M, Ohtsu H, Suzuki H, Nakashima H, Brailoiu E, Dun NJ et al. (2005). G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor. J Biol Chem 280: 2659226599.
  • Milojevic T, Reiterer V, Stefan E, Korkhov VM, Dorostkar MM, Ducza E et al. (2006). The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor. Mol Pharmacol 69: 10831094.
  • Mogi M, Iwai M, Horiuchi M (2009). New insights into the regulation of angiotensin receptors. Curr Opin Nephrol Hypertens 18: 138143.
  • Molino M, Barnathan ES, Numerof R, Clark J, Dreyer M, Cumashi A et al. (1997). Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem 272: 40434049.
  • Moore CA, Milano SK, Benovic JL (2007). Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol 69: 451482.
  • Moore EL, Salvatore CA (2012). Targeting a family B GPCR/RAMP receptor complex: CGRP receptor antagonists and migraine. Br J Pharmacol 166: 6678.
  • Moore RH, Tuffaha A, Millman EE, Dai W, Hall HS, Dickey BF et al. (1999). Agonist-induced sorting of human beta2-adrenergic receptors to lysosomes during downregulation. J Cell Sci 112 (Pt 3): 329338.
  • Muller S, Dennemarker J, Reinheckel T (2012). Specific functions of lysosomal proteases in endocytic and autophagic pathways. Biochim Biophys Acta 1824: 3443.
  • Murphy JE, Padilla BE, Hasdemir B, Cottrell GS, Bunnett NW (2009). Endosomes: a legitimate platform for the signaling train. Proc Natl Acad Sci U S A 106: 1761517622.
  • Murphy JE, Roosterman D, Cottrell GS, Padilla BE, Feld M, Brand E et al. (2011). Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor. Am J Physiol Cell Physiol 301: C780C791.
  • Myers TJ, Brennaman LH, Stevenson M, Higashiyama S, Russell WE, Lee DC et al. (2009). Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding. Mol Biol Cell 20: 52365249.
  • Neal B, MacMahon S, Ohkubo T, Brnabic A, Tonkin A (2002). Effects of the vasopeptidase inhibitor, omapatrilat, in 723 patients with coronary heart disease. J Renin Angiotensin Aldosterone Syst 3: 270276.
  • Nystedt S, Emilsson K, Wahlestedt C, Sundelin J (1994). Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci U S A 91: 92089212.
  • Nystedt S, Emilsson K, Larsson AK, Strombeck B, Sundelin J (1995a). Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. Eur J Biochem 232: 8489.
  • Nystedt S, Larsson AK, Aberg H, Sundelin J (1995b). The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression. J Biol Chem 270: 59505955.
  • Oakley RH, Laporte SA, Holt JA, Caron MG, Barak LS (2000). Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J Biol Chem 275: 1720117210.
  • Ohtsu H, Dempsey PJ, Eguchi S (2006). ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. Am J Physiol Cell Physiol 291: C110.
  • Olias G, Viollet C, Kusserow H, Epelbaum J, Meyerhof W (2004). Regulation and function of somatostatin receptors. J Neurochem 89: 10571091.
  • Ondetti MA, Rubin B, Cushman DW (1977). Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents. Science 196: 441444.
  • Padilla BE, Cottrell GS, Roosterman D, Pikios S, Muller L, Steinhoff M et al. (2007). Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. J Cell Biol 179: 981997.
  • Paolillo M, Schinelli S (2008). Therapeutic targeting of g-protein coupled receptor-mediated epidermal growth factor receptor transactivation in human glioma brain tumors. Mini Rev Med Chem 8: 14181428.
  • Pedersen-Bjergaard U, Nielsen LB, Jensen K, Edvinsson L, Jansen I, Olesen J (1991). Calcitonin gene-related peptide, neurokinin A and substance P: effects on nociception and neurogenic inflammation in human skin and temporal muscle. Peptides 12: 333337.
  • Pelayo JC, Poole DP, Steinhoff M, Cottrell GS, Bunnett NW (2011). Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones. J Physiol 589 (Pt 21): 52135230.
  • Pierce KL, Tohgo A, Ahn S, Field ME, Luttrell LM, Lefkowitz RJ (2001). Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding. J Biol Chem 276: 2315523160.
  • Pietri M, Schneider B, Mouillet-Richard S, Ermonval M, Mutel V, Launay JM et al. (2005). Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells. FASEB J 19: 10781087.
  • Pitcher J, Lohse MJ, Codina J, Caron MG, Lefkowitz RJ (1992). Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms. Biochemistry 31: 31933197.
  • Pitcher JA, Payne ES, Csortos C, DePaoli-Roach AA, Lefkowitz RJ (1995). The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. Proc Natl Acad Sci U S A 92: 83438347.
  • Porrello ER, Delbridge LM, Thomas WG (2009). The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor. Front Biosci 14: 958972.
  • Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C et al. (1999). EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402: 884888.
  • Quinton TM, Kim S, Derian CK, Jin J, Kunapuli SP (2004). Plasmin-mediated activation of platelets occurs by cleavage of protease-activated receptor 4. J Biol Chem 279: 1843418439.
  • Raddant AC, Russo AF (2011). Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation. Expert Rev Mol Med 13: e36.
  • Ramachandran R, Mihara K, Mathur M, Rochdi MD, Bouvier M, Defea K et al. (2009). Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways. Mol Pharmacol 76: 791801.
  • Ramachandran R, Mihara K, Chung H, Renaux B, Lau CS, Muruve DA et al. (2011). Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2). J Biol Chem 286: 2463824648.
  • Ramaekers CH, Wouters BG (2011). Regulatory functions of ubiquitin in diverse DNA damage responses. Curr Mol Med 11: 152169.
  • Rao GN, Delafontaine P, Runge MS (1995). Thrombin stimulates phosphorylation of insulin-like growth factor-1 receptor, insulin receptor substrate-1, and phospholipase C-gamma 1 in rat aortic smooth muscle cells. J Biol Chem 270: 2787127875.
  • Rawlings ND, Barrett AJ, Bateman A (2012). MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Res 40 (Database issue): D343D350.
  • Regamey F, Maillard M, Nussberger J, Brunner HR, Burnier M (2002). Renal hemodynamic and natriuretic effects of concomitant Angiotensin-converting enzyme and neutral endopeptidase inhibition in men. Hypertension 40: 266272.
  • Reubi JC, Hacki WH, Lamberts SW (1987a). Hormone-producing gastrointestinal tumors contain a high density of somatostatin receptors. J Clin Endocrinol Metab 65: 11271134.
  • Reubi JC, Lang W, Maurer R, Koper JW, Lamberts SW (1987b). Distribution and biochemical characterization of somatostatin receptors in tumors of the human central nervous system. Cancer Res 47: 57585764.
  • Reubi JC, Maurer R, von Werder K, Torhorst J, Klijn JG, Lamberts SW (1987c). Somatostatin receptors in human endocrine tumors. Cancer Res 47: 551558.
  • Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W (2002). Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 296: 18801882.
  • Roosterman D, Cottrell GS, Padilla BE, Muller L, Eckman CB, Bunnett NW et al. (2007). Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling. Proc Natl Acad Sci U S A 104: 1183811843.
  • Roosterman D, Kempkes C, Cottrell GS, Padilla BE, Bunnett NW, Turck CW et al. (2008). Endothelin-converting enzyme-1 degrades internalized somatostatin-14. Endocrinology 149: 22002207.
  • Roth NS, Campbell PT, Caron MG, Lefkowitz RJ, Lohse MJ (1991). Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A 88: 62016204.
  • Rothmeier AS, Ruf W (2012). Protease-activated receptor 2 signaling in inflammation. Semin Immunopathol 34: 133149.
  • Sambrano GR, Huang W, Faruqi T, Mahrus S, Craik C, Coughlin SR (2000). Cathepsin G activates protease-activated receptor-4 in human platelets. J Biol Chem 275: 68196823.
  • Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR (2001). Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature 413: 7478.
  • Scase TJ, Heath MF, Evans RJ (1997). Cloning of PAR3 cDNA from human platelets, and human erythroleukemic and human promonocytic cell lines. Blood 90: 21132114.
  • Schafer B, Marg B, Gschwind A, Ullrich A (2004). Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival. J Biol Chem 279: 4792947938.
  • Sefton BM, Rubin H (1970). Release from density dependent growth inhibition by proteolytic enzymes. Nature 227: 843845.
  • Shenoy SK, Lefkowitz RJ (2003). Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. J Biol Chem 278: 1449814506.
  • Shenoy SK, Lefkowitz RJ (2011). beta-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci 32: 521533.
  • Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ (2001). Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science 294: 13071313.
  • Shenoy SK, Barak LS, Xiao K, Ahn S, Berthouze M, Shukla AK et al. (2007). Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. J Biol Chem 282: 2954929562.
  • Shenoy SK, Modi AS, Shukla AK, Xiao K, Berthouze M, Ahn S et al. (2009). Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc Natl Acad Sci U S A 106: 66506655.
  • Showkathali R, Natarajan A (2012). Antiplatelet and antithrombin strategies in acute coronary syndrome: state-of-the-art review. Curr Cardiol Rev PMID: 22935021 [Epub ahead of print].
  • Simaan M, Bedard-Goulet S, Fessart D, Gratton JP, Laporte SA (2005). Dissociation of beta-arrestin from internalized bradykinin B2 receptor is necessary for receptor recycling and resensitization. Cell Signal 17: 10741083.
  • SOLVD (1991). Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD Investigators. N Engl J Med 325: 293302.
  • Starostina NG, Kipreos ET (2012). Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors. Trends Cell Biol 22: 3341.
  • Suzuki T, Moraes TJ, Vachon E, Ginzberg HH, Huang TT, Matthay MA et al. (2005). Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Am J Respir Cell Mol Biol 33: 231247.
  • Suzuki T, Yamashita C, Zemans RL, Briones N, Van Linden A, Downey GP (2009). Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway. Am J Respir Cell Mol Biol 41: 742755.
  • Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, Craik CS (2000). Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. J Biol Chem 275: 2633326342.
  • Tanida S, Kataoka H, Mizoshita T, Shimura T, Kamiya T, Joh T (2010). Intranuclear translocation signaling of HB-EGF carboxy-terminal fragment and mucosal defense through cell proliferation and migration in digestive tracts. Digestion 82: 145149.
  • Tanowitz M, Von Zastrow M (2002). Ubiquitination-independent trafficking of G protein-coupled receptors to lysosomes. J Biol Chem 277: 5021950222.
  • Thanawala V, Kadam VJ, Ghosh R (2008). Enkephalinase inhibitors: potential agents for the management of pain. Curr Drug Targets 9: 887894.
  • Trapani AJ, Beil ME, Bruseo CW, Savage P, Firooznia F, Jeng AY (2004). CGS 35601 and its orally active prodrug CGS 37808 as triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme. J Cardiovasc Pharmacol 44 (Suppl. 1): S211S215.
  • Trivedi V, Boire A, Tchernychev B, Kaneider NC, Leger AJ, O'Callaghan K et al. (2009). Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site. Cell 137: 332343.
  • Tsao PI, von Zastrow M (2000). Type-specific sorting of G protein-coupled receptors after endocytosis. J Biol Chem 275: 1113011140.
  • Umekawa K, Hasegawa H, Tsutsumi Y, Sato K, Matsumura Y, Ohashi N (2000). Pharmacological characterization of a novel sulfonylureid-pyrazole derivative, SM-19712, a potent nonpeptidic inhibitor of endothelin converting enzyme. Jpn J Pharmacol 84: 715.
  • Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H et al. (2007). Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther 320: 113.
  • Vu TK, Hung DT, Wheaton VI, Coughlin SR (1991). Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64: 10571068.
  • Vucic D, Dixit VM, Wertz IE (2011). Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. Nat Rev Mol Cell Biol 12: 439452.
  • Wolfe BL, Marchese A, Trejo J (2007). Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1. J Cell Biol 177: 905916.
  • Wyatt D, Malik R, Vesecky AC, Marchese A (2011). Small ubiquitin-like modifier modification of arrestin-3 regulates receptor trafficking. J Biol Chem 286: 38843893.
  • Xu WF, Andersen H, Whitmore TE, Presnell SR, Yee DP, Ching A et al. (1998). Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci U S A 95: 66426646.
  • Yan Y, Shirakabe K, Werb Z (2002). The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J Cell Biol 158: 221226.
  • Yoshida N, Yoshikawa T (2008). Basic and translational research on proteinase-activated receptors: implication of proteinase/proteinase-activated receptor in gastrointestinal inflammation. J Pharmacol Sci 108: 415421.
  • Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G (2000). Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 342: 145153.
  • von Zastrow M, Sorkin A (2007). Signaling on the endocytic pathway. Curr Opin Cell Biol 19: 436445.
  • Zhang Z, Oliver P, Lancaster JR Jr, Schwarzenberger PO, Joshi MS, Cork J et al. (2001). Reactive oxygen species mediate tumor necrosis factor alpha-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate. FASEB J 15: 303305.
  • Zwick E, Wallasch C, Daub H, Ullrich A (1999). Distinct calcium-dependent pathways of epidermal growth factor receptor transactivation and PYK2 tyrosine phosphorylation in PC12 cells. J Biol Chem 274: 2098920996.