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Feline epitheliotrophic T-cell lymphoma with paraneoplastic eosinophilia – immunochemotherapy with vinblastine and human recombinant interferon α2b

Authors

  • T. A. Cave,

    Corresponding author
    1. Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden, Glasgow, UK.
      ‡T. A. Cave
      1 Jubilee Road
      Axbridge, Somerset BS26 2DA
      UK
      e-mail: oncovetuk@hotmail.com
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    • *

      Present address: Cave Referrals, 1 Jubilee Road, Axbridge, Somerset BS26 2DA, UK

  • E. A. Gault,

    1. Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden, Glasgow, UK.
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  • D. J. Argyle

    1. Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden, Glasgow, UK.
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    • Present address: Department of Medical Sciences, School of Veterinary Medicine, University of Winconsin-Madison, 2015 Linden Drive, Madison, WI 53706-1102, USA


‡T. A. Cave
1 Jubilee Road
Axbridge, Somerset BS26 2DA
UK
e-mail: oncovetuk@hotmail.com

Abstract

A cat with epitheliotrophic T-cell lymphoma with paraneoplastic eosinophilia is described. Initial attempts to control the disease with conventional therapies failed. The addition of recombinant human interferon α2b (rhINFα2b) resulted in a clinical, haematogenous and sonographic improvement for 49 days. The overall survival time from initial diagnosis was 100 days. Relapse was correlated with the development of serum antibodies directed against rhINFα2b. To our knowledge, this is the first report describing the clinical use of IFNα in the treatment of neoplasia in the cat.

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