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Incidence and risk factors for development of malignant neoplasia after feline renal transplantation and cyclosporine-based immunosuppression

Authors

  • C. W. Schmiedt,

    1. Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
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    • *

      Present address: Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

  • J. A. Grimes,

    1. Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
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  • G. Holzman,

    1. Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
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  • J. F. McAnulty

    Corresponding author
    1. Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
      Jonathan F. McAnulty
      Department of Surgical Sciences
      School of Veterinary Medicine
      University of Wisconsin-Madison
      2015 Linden Dr.
      Madison
      WI 53706-1100
      USA
      e-mail: mcanultj@svm.vetmed.wisc.edu
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Jonathan F. McAnulty
Department of Surgical Sciences
School of Veterinary Medicine
University of Wisconsin-Madison
2015 Linden Dr.
Madison
WI 53706-1100
USA
e-mail: mcanultj@svm.vetmed.wisc.edu

Abstract

The objective of this retrospective study is to report and analyse the incidence of and risk factors for post-transplant malignant neoplasia (PTMN) in feline renal transplant recipients (cases, n = 45) and compare incidence to a population of cats that did not receive a transplant (controls, n = 79). Information from the medical records of cases regarding signalment, blood work and concomitant disease, post operative cyclosporine concentrations, survival time (ST), and whether PTMN developed, the type of PTMN, time to occurrence (TTO), and ST after diagnosis was gathered. PTMN occurred in 11 of 45 (24%) cases, of which, four were lymphoma. Median TTO of all PTMN was 1020 days. Median TTO of lymphoma was 454 days. Median ST after diagnosis of PTMN was 15 days. No risk factors were identified. Compared with control cats, cases had more than six times higher odds of developing PTMN compared with control cats (P < 0.01).

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