Get access

Evaluation of a multidrug chemotherapy protocol with mitoxantrone based maintenance (CHOP-MA) for the treatment of canine lymphoma

Authors

  • A. T. Daters,

    1. Cancer Treatment Unit, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
    Search for more papers by this author
  • G. E. Mauldin,

    1. Cancer Treatment Unit, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
    Search for more papers by this author
    • *

      Present address: Cancer Centre for Animals, Western Veterinary Specialist and Emergency Centre, 1802-10th Avenue SW, Calgary, Alberta, Canada T3C 0J8.

  • G. N. Mauldin,

    1. Cancer Treatment Unit, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
    Search for more papers by this author
    • *

      Present address: Cancer Centre for Animals, Western Veterinary Specialist and Emergency Centre, 1802-10th Avenue SW, Calgary, Alberta, Canada T3C 0J8.

  • E. M. Brodsky,

    1. Veterinary Oncology and Hematology Center, Norwalk, CT, USA
    Search for more papers by this author
    • Present address: Veterinary Oncology and Hematology Center, 178 Connecticut Avenue, Norwalk, CT 06854, USA.

  • G. S. Post

    1. Veterinary Oncology and Hematology Center, Norwalk, CT, USA
    Search for more papers by this author
    • Present address: Veterinary Oncology and Hematology Center, 178 Connecticut Avenue, Norwalk, CT 06854, USA.


A. T. Daters Southeast Veterinary Specialists 3409 Division Street Metairie LA 70002, USA
email: adaters@svsvets.com

Abstract

The purpose of this study was to evaluate the efficacy of adding mitoxantrone to a cyclophosphamide, doxorubicin, vincristine, l-asparaginase and prednisone containing protocol. Sixty-five dogs with multicentric lymphoma were evaluated for overall remission and survival times. Remission and survival time versus stage, substage, pretreatment hypercalcaemia and pretreatment steroid administration were also evaluated. Overall median remission for dogs with multicentric lymphoma was 302 days and overall median survival was 622 days. Of the dogs with multicentric lymphoma, 23 (35%) received all scheduled mitoxantrone doses. Only median survival versus substage was found to be significant (substage a median survival was 679 days and substage b median survival was 302 days, P = 0.025). Increasing the total combined dose of doxorubicin and mitoxantrone may improve remission times when compared with historical controls, and further studies are needed to determine how best to utilize mitoxantrone in multidrug chemotherapy protocols for canine multicentric lymphoma.

Ancillary