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Histopathologic classification of 171 cases of canine and feline non-Hodgkin lymphoma according to the WHO

Authors

  • E. Vezzali,

    Corresponding author
    1. Department of Veterinary Public Health and Animal Pathology, Pathological Anatomy Service Alma Mater Studiorum-University of Bologna, Italy
    2. Pathology Department, R.T.C.-Research Toxicology Center S.p.A., Via Tito Speri 12-14, I-00040 Pomezia, Rome, Italy
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  • A. L. Parodi,

    1. Departement d’Anatomie Pathologique, Ecole Nationale Vétérinaire d’Alfort, France
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  • P. S. Marcato,

    1. Department of Veterinary Public Health and Animal Pathology, Pathological Anatomy Service Alma Mater Studiorum-University of Bologna, Italy
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  • G. Bettini

    1. Department of Veterinary Public Health and Animal Pathology, Pathological Anatomy Service Alma Mater Studiorum-University of Bologna, Italy
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E. Vezzali Pathology Department R.T.C.-Research Toxicology Center S.p.A. Via Tito Speri 12-14 I-00040 Pomezia Rome, Italy
e-mail: enrico.vezzali@tin.it

Abstract

A retrospective collection of 171 lymphoid neoplasms (123 dogs and 48 cats) was classified according to the Revised European–American Lymphoma (REAL) classification, adopted in 2002 by the World Health Organization (WHO), to evaluate the WHO system for categorization of canine and feline neoplasms. Microscopic examination was performed after standard hematoxylin–eosin staining and immunohistochemical labelling for B (CD79a) or T (CD3) cell phenotypes. B-cell lymphomas were prevalent in dogs and T-cell lymphomas in cats. B-Large cell lymphoma (B-LCL) frequently showed plasmacytoid differentiation; notably, two canine plasma cell tumours (PCT) expressed both CD79 and CD3. There were difficulties in differentiating B-lymphoblastic lymphoma (B-LBL) from Burkitt-type lymphoma. Furthermore, intestinal T-cell lymphoma (ITCL) exhibited a huge morphologic variability. Finally, multicentric mature small and thymic T-cell lymphomas were diagnosed, although these categories are not codified by the WHO classification.

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