Serum vascular endothelial growth factor in dogs with soft tissue sarcomas

Authors

  • G. Fernandes de Queiroz,

    1. Department of Animal Sciences, Federal Rural University of the Semi-Arid, Mossoró, RN, Brazil
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  • M. Lúcia Zaidan Dagli,

    1. Department of Pathology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, São Paulo, SP, Brazil
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  • S. Aparecida Meira,

    1. Department of Statistics, Institute of Earth Sciences, Federal University of Mato Grosso, Cuiabá, MT, Brazil
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  • J.  Maria Matera

    Corresponding author
    1. Department of Surgery, School of Veterinary Medicine and Animal Science, University of Sao Paulo, São Paulo, SP, Brazil
    • Department of Animal Sciences, Federal Rural University of the Semi-Arid, Mossoró, RN, Brazil
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Correspondence address: J. Maria Matera, DVM, MS, PhD, Av. Prof. Orlando Marques de Paiva, 87CEP 05508-900Cidade Universitária Armando de Salles Oliveira São Paulo, Brazil

e-mail: materajm@usp.br

Abstract

This work aimed to evaluate serum vascular endothelial growth factor (VEGF) in 25 dogs with soft tissue sarcoma, and in 30 healthy dogs. Blood was collected once time from the control animals and three times, in the same way, from animals with sarcoma. Blood count was performed in the blood collected, and serum VEGF was measured by enzyme-linked immunosorbent assay quantitative method. Serum VEGF in control animals was similar to patients with soft tissue sarcoma. There was a reduction in serum VEGF after the sarcoma resection. There was positive correlation between serum VEGF and neutrophil counts, and negative between VEGF and hemoglobin content in animals with sarcoma. Animals with hemangiopericytoma showed higher serum VEGF levels compared to the patients with malignant peripheral nerve sheath. Circulating blood cells can contribute to elevate VEGF serum concentrations in dogs with soft tissue sarcomas and a possible role of VEGF in the angiogenesis of these tumors.

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