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Intraperitoneal antineoplastic drug delivery: experience with a cyclophosphamide, vincristine and prednisolone protocol in cats with malignant lymphoma

Authors

  • E. Teske,

    Corresponding author
    1. Department of Clinical Sciences of Companion Animals, Veterinary Faculty, Utrecht University, Utrecht, The Netherlands
    • Correspondence address:

      E. Teske

      Department of Clinical Sciences of Companion Animals, Veterinary Faculty

      Utrecht University

      PO Box 80.154, 3508 TD

      Utrecht, The Netherlands

      e-mail: e.teske@uu.nl

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  • A. J. van Lankveld,

    1. Department of Clinical Sciences of Companion Animals, Veterinary Faculty, Utrecht University, Utrecht, The Netherlands
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  • G. R. Rutteman

    1. Department of Clinical Sciences of Companion Animals, Veterinary Faculty, Utrecht University, Utrecht, The Netherlands
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Abstract

In this retrospective study, the efficacy and safety were examined for an intraperitoneal chemotherapy protocol-cyclophosphamide, vincristine and prednisolone (IP-COP) in 26 cats with malignant lymphoma. Certainly in cats fiercely resisting IV administration the IP route is a more practical method, safer for the administrator and less stressful for the cat. Complete remission (CR) rate was 76.9% (n = 20). Median duration of first remission was 421 days. Estimated 1- and 2-year disease free period were 67.1 and 48.0%, respectively. Median duration of survival was 388 days and estimated overall 1- and 2-year survival periods were 54.7 and 46.9% respectively. Young cats had a more favourable prognosis. Reaching CR was essential for long-term survival. No specific IP-related adverse events (AE) were seen. AE were generally scored as mild and were not excessively abundant. These results indicate that the IP route is a safe and effective alternative for the administration of COP protocol chemotherapeutics.

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