Prolactin – to be reconsidered in canine mammary tumourigenesis?

Authors

  • E. Michel,

    Corresponding author
    1. Section of Small Animal Reproduction, Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    • Correspondence address:

      Dr. E. Michel

      Section of Small Animal Reproduction, Clinic of Reproductive Medicine, Vetsuisse Faculty

      University of Zurich

      Winterthurerstrasse 260, 8057 Zurich, Switzerland

      e-mail: erikamichel@bluewin.ch

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  • C. Rohrer Bley,

    1. Section of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
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  • M. P. Kowalewski,

    1. Institute of Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
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  • S. K. Feldmann,

    1. Section of Small Animal Reproduction, Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
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  • I. M. Reichler

    1. Section of Small Animal Reproduction, Clinic of Reproductive Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
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Abstract

Mammary tumours represent the most common neoplastic disease of the female dog, and the incidence in female dogs is much higher than in women. Whereas the influence of sexual steroids on breast cancer (BC) development in dogs has been studied, very little is known about the role of prolactin (PRL). New studies show that until recently, the importance of PRL in human BC development and progression has been highly underestimated. PRL plays a role in promoting benign as well as malignant neoplastic cell growth in BC in vitro and in vivo. Sporadic publications proposed a tumour promotor role in the dog. The goal of this review is to summarize our knowledge about PRL and human BC as well as canine mammary tumourigenesis, and propose future research in this area.

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