Prolactin – to be reconsidered in canine mammary tumourigenesis?
Article first published online: 28 JUN 2012
© 2012 John Wiley & Sons Ltd
Veterinary and Comparative Oncology
Volume 12, Issue 2, pages 93–105, June 2014
How to Cite
Michel, E., Rohrer Bley, C., Kowalewski, M. P., Feldmann, S. K. and Reichler, I. M. (2014), Prolactin – to be reconsidered in canine mammary tumourigenesis?. Veterinary and Comparative Oncology, 12: 93–105. doi: 10.1111/j.1476-5829.2012.00337.x
- Issue published online: 8 APR 2014
- Article first published online: 28 JUN 2012
- Manuscript Accepted: 1 JUN 2012
- Manuscript Revised: 18 MAY 2012
- Manuscript Received: 4 MAR 2012
- breast cancer;
- mammary tumour;
Mammary tumours represent the most common neoplastic disease of the female dog, and the incidence in female dogs is much higher than in women. Whereas the influence of sexual steroids on breast cancer (BC) development in dogs has been studied, very little is known about the role of prolactin (PRL). New studies show that until recently, the importance of PRL in human BC development and progression has been highly underestimated. PRL plays a role in promoting benign as well as malignant neoplastic cell growth in BC in vitro and in vivo. Sporadic publications proposed a tumour promotor role in the dog. The goal of this review is to summarize our knowledge about PRL and human BC as well as canine mammary tumourigenesis, and propose future research in this area.