Cognition in liver disease
Article first published online: 6 JAN 2005
Volume 25, Issue 1, pages 1–8, February 2005
How to Cite
Collie, A. (2005), Cognition in liver disease. Liver International, 25: 1–8. doi: 10.1111/j.1478-3231.2005.01012.x
- Issue published online: 7 FEB 2005
- Article first published online: 6 JAN 2005
- Received 14 April 2004, accepted 27 June 2004
- hepatic encephalopathy;
- hepatitis C;
- liver disease;
- primary biliary cirrhosis;
- Wilson's disease
Abstract: Background: Cognitive dysfunction has been observed in a range of liver diseases including chronic hepatitis C virus, alcoholic liver disease, primary biliary cirrhosis and Wilson's disease. Such dysfunction may range from mild cognitive changes to overt hepatic encephalopathy, and represents a significant complication of liver disease that may negatively impact the patient's quality of life, and normal activities of daily living (e.g., driving).
Method: This article reviews the published evidence relating to cognitive dysfunction in liver disease.
Outcome: Issues of definition, diagnosis, epidemiology, aetiology, treatment and outcome are discussed. Particular attention is devoted to identifying the mild cognitive changes that occur in liver diseases of different aetiology.