Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2005 update

  1. Yun-Fan Liaw1,
  2. Nancy Leung2,
  3. Richard Guan3,
  4. George K.K. Lau4,
  5. Ismail Merican5,
  6. Geoff McCaughan6,
  7. Edward Gane7,
  8. Jia-Horng Kao8,
  9. Masao Omata9,
  10. for the Asian-Pacific consensus update working party on chronic hepatitis B1

Article first published online: 21 MAY 2005

DOI: 10.1111/j.1478-3231.2005.01134.x

Issue

Liver International

Liver International

Volume 25, Issue 3, pages 472–489, June 2005

Additional Information

How to Cite

Liaw, Y.-F., Leung, N., Guan, R., Lau, G. K., Merican, I., McCaughan, G., Gane, E., Kao, J.-H., Omata, M. and for the Asian-Pacific consensus update working party on chronic hepatitis B (2005), Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2005 update. Liver International, 25: 472–489. doi: 10.1111/j.1478-3231.2005.01134.x

Author Information

  1. 1

    Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan,

  2. 2

    Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Chinese University of Hong Kong, Hong Kong, China,

  3. 3

    Medical Clinic One, Mount Elizabeth Medical Centre, Singapore,

  4. 4

    Faculty of Medicine, University of Hong Kong, Hong Kong, China,

  5. 5

    Hospital Selayang, Institute for Medical Research, Kuala Lumpur, Malaysia,

  6. 6

    AW Morrow Gastroenterology and Liver Laboratory, Royal Prince Alfred Hospital, Sydney, Australia,

  7. 7

    New Zealand Liver Transplant Unit, Auckland Hospital, Auckland, New Zealand,

  8. 8

    Hepatitis Research Centre, National Taiwan University Hospital, Taipei, Taiwan,

  9. 9

    Department of Gastroenterology, University of Tokyo, Tokyo, Japan

*Prof. Yun-Fan Liaw, Liver Research Unit, Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan. Tel: 886 3 3281200 ext. 8120 Fax: 886 3 3282824 e-mail: liveryfl@so-net.net.tw

Publication History

  1. Issue published online: 21 MAY 2005
  2. Article first published online: 21 MAY 2005
  3. Received 19 January 2005, accepted 15 March 2005

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Keywords:

  • adefovir;
  • chronic hepatitis B;
  • hepatic decompensation;
  • interferon;
  • lamivudine;
  • liver transplantation

Abstract:

Background/Aims: A large amount of new data on the treatment of chronic hepatitis B has become available such that the 2003 consensus statement requires revision and update.

Methods: New data were presented, discussed and debated in an expert pre-meeting to draft a revision. The revised contents were finalized after discussion in a general meeting of APASL.

Results: Conceptual background, including the efficacy and safety profile of currently available and emerging drugs, was reviewed. Nineteen recommendations were formed and unresolved issues and areas for further study were suggested.

Conclusion: The current therapy of chronic hepatitis B is modestly effective but not satisfactory. The development of new drugs and new strategies is required to further improve the outcomes of treatment.

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