Tumor growth-promoting cellular host response during liver atrophy after portal occlusion
Article first published online: 30 JUN 2005
Volume 25, Issue 5, pages 994–1001, October 2005
How to Cite
Mueller, L., Goettsche, J., Abdulgawad, A., Vashist, Y. K., Meyer, J., Wilms, C., Hillert, C., Rogiers, X. and Broering, D. C. (2005), Tumor growth-promoting cellular host response during liver atrophy after portal occlusion. Liver International, 25: 994–1001. doi: 10.1111/j.1478-3231.2005.01138.x
- Issue published online: 14 JUL 2005
- Article first published online: 30 JUN 2005
- Received 1 August 2004, accepted 30 January 2005
- heme oxygenase-1;
- portal embolization;
- tumor invasion
Abstract: Background/Aims: Clinical observations suggest cancer progression after preoperative segmental portal vein occlusion, a procedure to prevent liver failure after major hepatic resections. The aim of this study was to determine whether portal occlusion induces host reactions which promote cancer invasion and angiogenesis.
Methods: The rat model of portal branch ligation (PBL) was compared with partial hepatectomy (PH) and sham operation (SO) and evaluated for the expression of heat shock protein-70 (hsp70), heme oxygenase-1 (hmox1), early growth response gene-1 (Egr-1) and urokinase-type plasminogen activator (uPA), its inhibitor (PAI-1) and receptor (uPAR).
Results: Portal deprivation after PBL was associated with a regression of liver tissue to 25% of its original mass within 8 days with only modest fibrotic changes. During the progression of atrophy, there were significant inductions of hsp70-, hmox1- and Egr-1-mRNA in comparison with regenerating liver tissue. PAI-1-specific mRNA was transiently elevated at 3 – 48 h after PBL in the atrophying lobes, whereas uPA and uPAR were unaffected in comparison with PH or SO.
Conclusion: Hepatic atrophy caused by PBL is associated with increased expression of genes known to promote tumor growth. These host events represent a possible explanation for the tumor progression after portal occlusion and require further evaluation.