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Keywords:

  • alcoholic cirrhosis;
  • ethanol abuse;
  • genetic polymorphism;
  • ransforming growth factor β

Abstract: Background/aims: There are wide interindividual differences in the risk of developing alcoholic cirrhosis. Transforming growth factor β1 (TGF-β1) is the main cytokine involved in liver fibrogenesis. The TGF1 gene is polymorphic at several sites and these polymorphisms are probably related to differences in the rate of TGF-β1 synthesis. Our aim has been to analyse the influence of the TGF1 gene polymorphisms in the predisposition to advanced alcoholic liver disease (ALD) in ethanol abusers.

Methods: TGF1 single nucleotide polymorphisms at positions –509 (C or T), +869 (C or T, codon 10), and +915 (C or G, codon 25) were examined in 165 alcoholics with advanced ALD and in 185 healthy controls.

Results: Among the 94 male patients with oesophageal varices, those carrying the GG genotype at position +915 were diagnosed at an older age than the remaining patients (age 52.1 years, standard deviation (SD) 9.9 vs. 45 SD 13.4, P=0.012). No other statistically significant differences were found in the distribution of the three TGF1 polymorphisms analysed individually or as combined haplotypes.

Conclusions: The polymorphisms at the TGF1 gene analysed in this study are probably not related to the risk of advanced ALD.