Polymorphisms in the transforming growth factor-β1 gene (TGF-β1) and the risk of advanced alcoholic liver disease
Article first published online: 14 JUL 2005
Volume 25, Issue 5, pages 935–939, October 2005
How to Cite
Oliver, J., Agúndez, J. A. G., Morales, S., Fernández-Arquero, M., Fernández-Gutierrez, B., De La Concha, E. G., Díaz-Rubio, M., Martín, J. and Ladero, J. M. (2005), Polymorphisms in the transforming growth factor-β1 gene (TGF-β1) and the risk of advanced alcoholic liver disease. Liver International, 25: 935–939. doi: 10.1111/j.1478-3231.2005.01150.x
- Issue published online: 14 JUL 2005
- Article first published online: 14 JUL 2005
- Received 18 November 2004, accepted 6 April 2005
- alcoholic cirrhosis;
- ethanol abuse;
- genetic polymorphism;
- ransforming growth factor β
Abstract: Background/aims: There are wide interindividual differences in the risk of developing alcoholic cirrhosis. Transforming growth factor β1 (TGF-β1) is the main cytokine involved in liver fibrogenesis. The TGF-β1 gene is polymorphic at several sites and these polymorphisms are probably related to differences in the rate of TGF-β1 synthesis. Our aim has been to analyse the influence of the TGF-β1 gene polymorphisms in the predisposition to advanced alcoholic liver disease (ALD) in ethanol abusers.
Methods: TGF-β1 single nucleotide polymorphisms at positions –509 (C or T), +869 (C or T, codon 10), and +915 (C or G, codon 25) were examined in 165 alcoholics with advanced ALD and in 185 healthy controls.
Results: Among the 94 male patients with oesophageal varices, those carrying the GG genotype at position +915 were diagnosed at an older age than the remaining patients (age 52.1 years, standard deviation (SD) 9.9 vs. 45 SD 13.4, P=0.012). No other statistically significant differences were found in the distribution of the three TGF-β1 polymorphisms analysed individually or as combined haplotypes.
Conclusions: The polymorphisms at the TGF-β1 gene analysed in this study are probably not related to the risk of advanced ALD.