Hepatitis C-associated autoimmunity in patients coinfected with HIV
Article first published online: 11 NOV 2005
Volume 25, Issue 6, pages 1114–1121, December 2005
How to Cite
Woitas, R. P., Stoschus, B., Terjung, B., Vogel, M., Kupfer, B., Brackmann, H. H., Rockstroh, J. K., Sauerbruch, T. and Spengler, U. (2005), Hepatitis C-associated autoimmunity in patients coinfected with HIV. Liver International, 25: 1114–1121. doi: 10.1111/j.1478-3231.2005.01159.x
- Issue published online: 11 NOV 2005
- Article first published online: 11 NOV 2005
- Received 6 December 2004, accepted 26 April 2005
Abstract: Background: Hepatitis C virus (HCV) infection is associated with multiple extrahepatic manifestations. It is unclear to what extent extrahepatic manifestations occur in HIV/HCV coinfection.
Methods: We prospectively assessed cross-sectional frequencies of autoimmune manifestations in HIV/HCV-coinfected patients (n=98), HIV-mono-infected (n=45) and HCV-mono-infected patients (n=78). Diagnostic vasculitis scores, HCV and HIV loads, CD4 cell counts, thyroid-, cardiolipin-, non-organ-specific tissue antibodies (nuclear, smooth muscle, anti-liver–kidney–microsome, neutrophil–cytoplasmic) and cryoglobulins were determined.
Results: Synergistic effects of HCV and HIV infection were observed with respect to the prevalence of antibodies against thyroglobulin (HCV infection 15.4%, HIV infection 8.8%, HIV/HCV coinfection 30.6%; P<0.001) and cardiolipin antibodies (HCV infection 9.0%, HIV infection 31%, HIV/HCV coinfection 46%; P<0.001). Cryoglobulinemia type III, was significantly associated with HCV infection (HCV, 25.6%; HIV/HCV, 20.4%) but not with HIV infection (4.4%, P<0.05). Rheumatoid factor was commonly detected in patients with HCV infection (48%), but occurred considerably less frequently in patients with HIV infection (4.4%) or HIV/HCV coinfection (9.5%, P<0.01).
Conclusion: HIV coinfection appears to differentially modulate the frequency of HCV-related autoimmunity. However, autoimmunity is rarely accompanied by clinical manifestations.