Successful liver transplantation and delivery in a woman with fulminant hepatic failure occurring during the second trimester of pregnancy
Version of Record online: 10 APR 2006
Volume 26, Issue 4, pages 494–497, May 2006
How to Cite
Jarufe, N., Soza, A., Pérez-Ayuso, R. M., Poblete, J. A., González, R., Guajardo, M., Hernandez, V., Riquelme, A., Arrese, M. and Martínez, J. (2006), Successful liver transplantation and delivery in a woman with fulminant hepatic failure occurring during the second trimester of pregnancy. Liver International, 26: 494–497. doi: 10.1111/j.1478-3231.2006.01246.x
- Issue online: 10 APR 2006
- Version of Record online: 10 APR 2006
- Received 17 October 2005,accepted 27 December 2005
- acute liver failure;
- high-risk pregnancy;
- liver transplantation
Abstract: Background: Severe liver dysfunction occurring during pregnancy is an unusual but dramatic event that poses special technical and ethical issues because it involves two lives.
Methods and Results: We report the case of a 35-year-old woman with cryptogenic fulminant hepatic failure who underwent successful orthotopic liver transplantation at 22 weeks of pregnancy. After a relatively uneventful post-operative course she delivered a normal offspring at the 27th week of gestation. There were no obstetrical complications and neonatal outcome was excellent. After a year of follow-up, the patient is doing well,and the newborn has exhibited normal psychomotor and weight/height development.
Conclusion: This case illustrates the challenge of treating fulminant hepatic failure during pregnancy and demonstrates that liver transplantation is a feasible therapeutic option for treatment of patients with this condition, allowing successful completion of pregnancy.