Ring-shaped appearance in liver-specific image with Levovist: a characteristic enhancement pattern for hypervascular benign nodule in the liver of heavy drinkers
Article first published online: 27 JUN 2006
Volume 26, Issue 6, pages 688–694, August 2006
How to Cite
Maruyama, H., Matsutani, S., Kondo, F., Yoshizumi, H., Kobayashi, S., Okugawa, H., Ebara, M. and Saisho, H. (2006), Ring-shaped appearance in liver-specific image with Levovist: a characteristic enhancement pattern for hypervascular benign nodule in the liver of heavy drinkers. Liver International, 26: 688–694. doi: 10.1111/j.1478-3231.2006.01286.x
- Issue published online: 27 JUN 2006
- Article first published online: 27 JUN 2006
- Received 7 February 2006,accepted 17 April 2006
- contrast agent;
- hepatic nodule;
Abstract: Background/Aims: The aim was to clarify the features of contrast-enhanced ultrasound (CEUS) with Levovist for diagnosis of hypervascular benign nodules in the liver of heavy drinkers.
Patients and methods: Seven heavy drinkers with hypervascular nodules in the liver were studied. Findings of CEUS with Levovist (wide-band Doppler, 7/7), contrast-enhanced computed tomography (CECT, 7/7) and magnetic resonance imaging (MRI, 5/7) were compared for one nodule in each patient.
Results: Diagnosis of all seven nodules on CECT was HCC, whereas pathological results were HCC for four nodules and benign lesion for three nodules. The former four showed compatible findings for HCC on CEUS (4/4) and MRI (2/4). However, the latter three showed characteristic liver-specific sonograms with a ring-shaped appearance – peripheral enhancement with a central non-enhanced area. Two of the three nodules showed decreased signal-intensity in the periphery on SPIO-enhanced MRI.
Conclusions: The ring-shaped appearance on liver-specific sonograms with Levovist may be a useful sign for the differential diagnosis of hypervascular benign nodule from HCC in heavy drinkers.