The AST/ALT ratio as an indicator of cirrhosis in patients with PBC
Article first published online: 3 AUG 2006
Volume 26, Issue 7, pages 840–845, September 2006
How to Cite
Nyblom, H., Björnsson, E., Simrén, M., Aldenborg, F., Almer, S. and Olsson, R. (2006), The AST/ALT ratio as an indicator of cirrhosis in patients with PBC. Liver International, 26: 840–845. doi: 10.1111/j.1478-3231.2006.01304.x
- Issue published online: 3 AUG 2006
- Article first published online: 3 AUG 2006
- Received 1 February 2006,accepted 8 May 2006
- alanine aminotransferase;
- aspartate aminotransferase;
- liver cirrhosis;
- primary biliary cirrhosis;
Abstract: Objectives: A non-invasive, simple and non-expensive test to predict cirrhosis would be highly desirable. The aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio has been proven to be such an indicator of cirrhosis in alcoholic liver disease, hepatitis C.
Aim: To test whether the AST/ALT ratio is a marker of cirrhosis also in patients with primary biliary cirrhosis (PBC).
Methods: The study consisted of 160 patients. In 126 patients, we had clinical and laboratory data at the time of diagnosis and follow-up with outcome: liver-related death, liver transplantation and survival. In 121 patients, we had laboratory data and liver histology.
Results: We found that the AST/ALT ratio was significantly higher in cirrhotic patients than in non-cirrhotic patients. A high AST/ALT ratio was significantly associated with esophageal varices and ascites. In a multivariate analysis, bilirubin and ALP were predictors of poor prognosis.
Conclusion: The AST/ALT ratio seems to be of clinical value as a hint to the diagnosis of cirrhosis in patients with PBC but not as a prognostic factor.