Usefulness of contrast-enhanced ultrasonography with abdominal virtual ultrasonography in assessing therapeutic response in hepatocellular carcinoma treated with radiofrequency ablation

Authors

  • Yoshiyasu Kisaka,

    1. Third Department of Internal Medicine,
    2. The Endscopy center
    3. The Department Radiology, Ehime University School of Medicine, Shitsukawa, Tohon-shi, Ehime, Japan
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  • Masasi Hirooka,

    1. Third Department of Internal Medicine,
    2. The Endscopy center
    3. The Department Radiology, Ehime University School of Medicine, Shitsukawa, Tohon-shi, Ehime, Japan
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  • Teru Kumagi,

    1. Third Department of Internal Medicine,
    2. The Endscopy center
    3. The Department Radiology, Ehime University School of Medicine, Shitsukawa, Tohon-shi, Ehime, Japan
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  • Takahide Uehara,

    1. Third Department of Internal Medicine,
    2. The Endscopy center
    3. The Department Radiology, Ehime University School of Medicine, Shitsukawa, Tohon-shi, Ehime, Japan
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  • Yoichi Hiasa,

    1. Third Department of Internal Medicine,
    2. The Endscopy center
    3. The Department Radiology, Ehime University School of Medicine, Shitsukawa, Tohon-shi, Ehime, Japan
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  • Seishi Kumano,

    1. Third Department of Internal Medicine,
    2. The Endscopy center
    3. The Department Radiology, Ehime University School of Medicine, Shitsukawa, Tohon-shi, Ehime, Japan
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  • Hiroaki Tanaka,

    1. Third Department of Internal Medicine,
    2. The Endscopy center
    3. The Department Radiology, Ehime University School of Medicine, Shitsukawa, Tohon-shi, Ehime, Japan
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  • Kojiro Michitaka,

    1. Third Department of Internal Medicine,
    2. The Endscopy center
    3. The Department Radiology, Ehime University School of Medicine, Shitsukawa, Tohon-shi, Ehime, Japan
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  • Norio Horiike,

    1. Third Department of Internal Medicine,
    2. The Endscopy center
    3. The Department Radiology, Ehime University School of Medicine, Shitsukawa, Tohon-shi, Ehime, Japan
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  • Teruhito Mochizuki,

    1. Third Department of Internal Medicine,
    2. The Endscopy center
    3. The Department Radiology, Ehime University School of Medicine, Shitsukawa, Tohon-shi, Ehime, Japan
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  • Morikazu Onji

    1. Third Department of Internal Medicine,
    2. The Endscopy center
    3. The Department Radiology, Ehime University School of Medicine, Shitsukawa, Tohon-shi, Ehime, Japan
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Morikazu Onji, Third Department of Internal Medicine, Ehime University School of Medicine, Shitsukawa 454, Tohon-shi, Ehime 791-0295, Japan.
Tel: +81 89 960 5308
Fax: +81 89 960 5310
e-mail: onjimori@m.ehime-u.ac.jp

Abstract

Abstract: Objective: Contrast-enhanced computed tomography (CECT) is regarded as the gold standard for assessing the efficacy of radiofrequency ablation (RFA) against hepatocellular carcinoma (HCC). We evaluated the efficacy of virtual ultrasonography (VUS) with contrast-enhanced ultrasonography (CEUS) vs. CECT for assessing the response to RFA.

Materials and methods: Study 1: The therapeutic responses in 22 patients with 26 HCC nodules were assessed by CEUS with VUS as well as by CECT. The efficacy of treatment was based on whether the safety margin was greater than 5 mm after RFA.

Study 2: In seven patients with seven HCC nodules, the nodules were treated by RFA and the therapeutic efficacy was assessed by CEUS with VUS. The number of RFA sessions was assessed.

Results: Compared with CECT, CEUS with VUS had a specificity of 77%, a sensitivity of 91.6%, and an accuracy of 84%. When the therapeutic response to RFA was analyzed by CECT only, 1.86±0.69 assessments (mean) were required, while when response was assessed by CEUS with VUS, 1.14±0.38 CECT assessments were required (P=0.03).

Conclusion: CEUS with VUS is effective in assessing the therapeutic response to RFA of HCC. Moreover, the number of CECT scans required is reduced by this approach.

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