A novel therapeutic drug (copper nicotinic acid complex) for non-alcoholic fatty liver



This article is corrected by:

  1. Errata: ERRATUM Volume 27, Issue 8, 1156, Article first published online: 6 September 2007

Ragaa H. M. Salama, Department of Medical Biochemistry, Faculty of Medicine, Assuit University, Assiut, Egypt
Tel: +20 88 236 9112
Fax: +20 88 233 2278
e-mail: ragaa_2002@yahoo.com


Background: Fatty liver is the accumulation of fat in liver cells, which leads to disruption of the normal liver structure and function.

Methods: A non-alcoholic fatty liver rat model received copper (Cu) (I)-nicotinate complex [CuCl(HNA)2] for 4 weeks.

Results: Clinical signs and histopathological examinations showed obvious improvements in rats that received Cu complex who were continuously on an (HCFF) diet than those returned to standard diet with Cu complex. The improvement was matched in total lipids in sera and hepatic tissue, with disappearance of fat droplets from liver sections. Furthermore, the gain in body weight and the corresponding decrease in liver weight, decreased liver transaminases and alkaline phosphatase were prominent. The oxidative stress markers such as nitric oxide, lipid peroxides, glutathione and superoxide dismutase were obviously changed to healthy normal levels.

Conclusion: The Cu complex may serve as a novel chemical restoring agent in fatty degenerated liver cells and for renewal of their structure and functions. However, clinical trials are required for more evaluation of the Cu complex in humans.