Hepatic steatosis correlates with the postoperative recurrence of hepatitis C virus-associated hepatocellular carcinoma
Article first published online: 9 MAR 2007
Volume 27, Issue 5, pages 620–626, June 2007
How to Cite
Takuma, Y., Nouso, K., Makino, Y., Saito, S., Takayama, H., Takahara, M., Takahashi, H., Murakami, I. and Takeuchi, H. (2007), Hepatic steatosis correlates with the postoperative recurrence of hepatitis C virus-associated hepatocellular carcinoma. Liver International, 27: 620–626. doi: 10.1111/j.1478-3231.2007.01462.x
- Issue published online: 9 MAR 2007
- Article first published online: 9 MAR 2007
- Received 15 November 2006accepted 16 January 2007
- curative resection;
- hepatic steatosis;
- hepatitis C virus;
- hepatocellular carcinoma;
- intrahepatic recurrence;
- stage of fibrosis
Background: Hepatic steatosis is a prominent feature of chronic hepatitis C. Hepatic steatosis was reported recently to be a risk factor for hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC).
Aim: To investigate whether hepatic steatosis influences the postoperative recurrence of HCV-associated HCC.
Methods: A retrospective study was conducted in 88 patients undergoing curative resection of HCV-associated HCC. Cumulative tumour recurrence rates were compared between steatosis-positive and steatosis-negative patients, and the factors affecting intrahepatic recurrence were assessed.
Results: The respective tumour recurrence rates at 1, 3, and 5 years were 19%, 76%, and 92% in the steatosis-positive group, and 12%, 52%, and 60% in the steatosis-negative group. The tumour recurrence rate of the steatosis-positive group was significantly higher than that of the steatosis-negative group (P=0.02). Hepatic steatosis [relative risk (RR)=3.31, 95% confidence intervals (CIs)=1.49–7.41, P=0.003], stage of fibrosis (RR=3.17, 95% CI=1.35–7.47, P=0.008), surgical procedure (RR=0.22, 95% CI=0.076–0.64, P=0.005), number of tumours (RR=5.24, 95% CI=1.63–16.80, P=0.005), size of the largest tumour (RR=3.52, 95% CI=1.28–9.69, P=0.02), and vascular invasion (RR=2.72, 95% CI=1.32–5.59, P=0.007) were independent factors for tumour recurrence rate by multivariate analysis.
Conclusions: Hepatic steatosis is a useful predictor of postoperative recurrence of HCV-related HCC.