Get access

Expression of microsomal prostaglandin E synthase-1 in human hepatocelluar carcinoma

Authors

  • Yasushi Takii,

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author
  • Seigo Abiru,

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author
  • Hikaru Fujioka,

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author
  • Minoru Nakamura,

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author
  • Atsumasa Komori,

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author
  • Masahiro Ito,

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author
  • Ken Taniguchi,

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author
  • Manabu Daikoku,

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author
  • Yumi Meda,

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author
  • Kazuyuki Ohata,

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author
  • Koji Yano,

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author
  • Shinji Shimoda,

    1. Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Higashi-ku, Fukuoka, Japan
    Search for more papers by this author
  • Hiroshi Yatsuhashi,

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author
  • Hiromi Ishibashi,

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author
  • Kiyoshi Migita

    1. Clinical Research Center, NHO Nagasaki Medical Center, Omura, Nagasaki, Japan
    2. Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Search for more papers by this author

Correspondence
Kiyoshi Migita, MD, Clinical Research Center, National Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki 856-8652, Japan
Tel: +81 957 52 3121
Fax: +81 957 54 0292
e-mail: migita@nmc.hosp.go.jp

Abstract

Background/Aims: The objective of this study was to evaluate the expression of microsomal prostaglandin E synthase-1 (mPGES-1) in hepatocellular carcinoma (HCC) tissues.

Methods: Forty surgically resected HCC tissues with adjacent non-tumorous liver tissues and 14 surgically resected, histologically normal liver tissues were used. The immunohistochemical expressions of the mPGES-1 protein in these HCC tissues and normal control livers were analysed. mPGES-1 mRNA expression was also analysed by the real-time polymerase chain reaction method using the same tissues.

Results: Microsomal prostaglandin E synthase-1 was not expressed in hepatocytes but instead in vascular endothelial cells and bile duct epithelial cells in normal liver tissues. The mPGES-1 expression in HCC tissues was significantly greater than its expression in the non-tumorous tissues. All types of HCC expressed more mPGES-1 than normal or hepatitis livers, and the levels of mPGES-1 expression in poorly differentiated HCC were similar to the levels in well-differentiated HCC. The mPGES-1 mRNA expression paralleled its protein expression in these tumorous and non-tumorous tissues.

Conclusions: The present study is the first to demonstrate a high expression of mPGES-1 in well-differentiated HCC as well as in poorly differentiated HCC. These findings suggest that mPGES-1 may play a role in the advanced as well as early stage of hepatocarcinogenesis.

Ancillary