Subgenotypes of hepatitis B virus genotype C do not correlate with disease progression of chronic hepatitis B in Taiwan
Article first published online: 13 AUG 2007
Volume 27, Issue 7, pages 983–988, September 2007
How to Cite
Tseng, T.-C., Liu, C.-J., Chen, P.-J., Lai, M.-Y., Lin, C.-L., Kao, J.-H. and Chen, D.-S. (2007), Subgenotypes of hepatitis B virus genotype C do not correlate with disease progression of chronic hepatitis B in Taiwan. Liver International, 27: 983–988. doi: 10.1111/j.1478-3231.2007.01546.x
- Issue published online: 13 AUG 2007
- Article first published online: 13 AUG 2007
- Received 28 November 2006accepted 22 March 2007
- basal core promoter;
- genotype C;
- hepatitis B virus;
Background: Hepatitis B virus (HBV) genotype C (HBV/C) has two subgenotypes: HBV/Cs and Ce. The prevalence and clinical implications of subgenotype Cs and Ce in Taiwanese HBV carriers remain unknown.
Methods: Subgenotypes of HBV/C were determined in 242 Taiwanese HBV carriers with various stages of liver disease. The clinical as well as virologic features between patients with HBV/Cs and HBV/Ce infection were further compared.
Results: HBV/Ce was the predominant subgenotype in Taiwan. The prevalence of HBV/Ce was 93.6% in the inactive carriers group, 84.2% in chronic hepatitis patients, 81.2% in cirrhosis patients, 92.5% in hepatocellular carcinoma (HCC) patients without cirrhosis and 91.9% in HCC patients with cirrhosis. There was no significant difference in the distribution of the HBV/C subgenotypes among patients with different stages of liver disease.
Conclusions: Subgenotypes of HBV/C may not have a clinical impact on the disease progression of chronic hepatitis B in Taiwan.