Plasmatic vitamin C in nontreated hepatitis C patients is negatively associated with aspartate aminotransferase
Article first published online: 10 OCT 2007
Volume 28, Issue 1, pages 54–60, January 2008
How to Cite
Souza dos Santos, R. M., De Bem, A. F., Colpo, E., Bertoncello, I., Nogueira, C. W. and Rocha, J. B. T. (2008), Plasmatic vitamin C in nontreated hepatitis C patients is negatively associated with aspartate aminotransferase. Liver International, 28: 54–60. doi: 10.1111/j.1478-3231.2007.01599.x
- Issue published online: 10 OCT 2007
- Article first published online: 10 OCT 2007
- Received 20 March 2007accepted 24 August 2007
- hepatitis C;
- oxidative stress;
- vitamin C
Objectives: To evaluate the possible relationship between aminotransferases levels and markers of oxidative stress in chronic hepatitis C patients.
Design and methods: Patients without treatment for hepatitis were divided in to group I (15–39 U/L); group II (41–76 U/L) and group III (81–311 U/L) of activity alanine aminotransferase (ALT). Blood markers of oxidative stress [catalase (CAT), glutathione peroxidase (GPx), thiobarbituric acid-reactive species (TBARS), nonprotein and protein thiol (NP-SH and P-SH) groups and vitamin C] were determined.
Results: P-SH and NP-SH levels, TBARS, GPx and CAT were not different between groups. Vitamin C was significantly decreased in groups II (P=0.03) and III (P=0.001) when compared with group I and correlated negatively with aspartate aminotransferase (AST; r=−0.29, P=0.042).
Conclusion: Vitamin C levels were negatively associated with AST, suggesting that vitamin C could be an additional indicator of hepatitis C severity.