Molecular characterization of hepatitis A virus in children with fulminant hepatic failure in Argentina
Article first published online: 20 NOV 2007
Volume 28, Issue 1, pages 47–53, January 2008
How to Cite
Munné, M. S., Vladimirsky, S., Moreiro, R., Ciocca, M., Cuarterolo, M., Otegui, L., Soto, S., Brajterman, L., Castro, R., Sasbón, J., Gianivelli, S., Buamscha, D., Quarleri, J. and González, J. E. (2008), Molecular characterization of hepatitis A virus in children with fulminant hepatic failure in Argentina. Liver International, 28: 47–53. doi: 10.1111/j.1478-3231.2007.01634.x
- Issue published online: 20 NOV 2007
- Article first published online: 20 NOV 2007
- Received 16 April 2007accepted 8 October 2007
- fulminant hepatic failure (FHF);
- hepatitis A virus (HAV);
- molecular analyses;
- sequence comparison
Background: Hepatitis A infection, a vaccine-preventable disease, is an important cause of fulminant hepatic failure (FHF) in children in Argentina. Universal vaccination in 1-year-old children was implemented in June 2005. The limited studies about the correlation between the characteristics of the hepatitis A virus (HAV) and FHF have been carried out in adults.
Methods: Samples from 41 children with FHF were studied from September 2003 to January 2006 and HAV RNA was detected, sequenced and analysed in the 5′ non-coding region and VP1/2A region.
Results: Eighteen HAV strains were characterized and found to be different at the nucleotide level from the self-limited acute infection strains that have been circulating in Argentina with no temporal or geographical pattern. They did not form a genetic cluster, but some of them were identical in the largest fragment characterized and some of them seemed to be more closely related in time and/or geographically.
Conclusion: Our results suggest that viral factors could be involved in the severity of the clinical presentation of HAV infection in children in Argentina.