Renal hepatitis C in the absence of detectable serum or hepatic virus


Dr Andrew J. Fowell, Liver Research Group, Division of Infection, Inflammation and Repair, Southampton General Hospital, University of Southampton, Mailpoint 811, Tremona Road, Southampton, SO16 6YD, UK
Tel: +44 23 8079 8970
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We report an apparently unique case where hepatitis C virus (HCV) RNA was identified in renal tissue from a patient with membranoproliferative glomerulonephritis and treated chronic hepatitis C, despite the absence of detectable virus in the serum or liver (COBAS Amplicor qualitative assay, lower limit of detection 50 IU/ml). The implications of this finding are discussed, with particular reference to current concepts regarding ‘occult’ hepatitis C infection.