Zinc modulates lithium-induced hepatotoxicity in rats
Article first published online: 12 MAR 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
Volume 28, Issue 4, pages 558–565, April 2008
How to Cite
Chadha, V. D., Bhalla, P. and Dhawan, D. K. (2008), Zinc modulates lithium-induced hepatotoxicity in rats. Liver International, 28: 558–565. doi: 10.1111/j.1478-3231.2008.01674.x
- Issue published online: 12 MAR 2008
- Article first published online: 12 MAR 2008
- Received 15 May 2007Accepted 3 December 2007
- liver marker enzymes;
- oxidative stress;
Aim: The present study explored the hepatoprotective role of zinc in lithium-induced hepatotoxicity.
Methods: Rats received either lithium treatment in diet at a dose level of 1.1 g/kg diet, zinc alone at a dose level of 227 mg/L in drinking water, and combined lithium plus zinc or drinking water alone for different time durations of 1, 2 and 4 months. This study explored the hepatic marker enzymes, antioxidant status and histopathological investigations in the liver of rats following different treatments.
Results: The activities of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and alkaline phosphatase were found to be elevated significantly following 2 and 4 months of lithium treatment. Lithium-treated rats showed a significant increase in the levels of lipid peroxidation and superoxide dismutase and a significant inhibition in the levels of reduced glutathione, catalase and glutathione-S-transferase, following 2 and 4 months of treatment. However, zinc co-administration revealed significant improvement in the altered activities of hepatic marker and antioxidant enzymes in comparison with lithium-treated animals. Lithium-treated rats also indicated drastic alterations in hepatic histoarchitecture and zinc co-administration resulted in improvement in the structure of hepatocytes.
Conclusion: The present study suggests the protective potential of zinc in lithium-induced hepatotoxicity.