Natural history and prognostic factors of primary biliary cirrhosis in Taiwan: a follow-up study up to 18 years
Version of Record online: 13 MAR 2008
© 2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard
Volume 28, Issue 9, pages 1305–1313, October 2008
How to Cite
Su, C.-W., Hung, H.-H., Huo, T.-I., Huang, Y.-H., Li, C.-P., Lin, H.-C., Lee, P.-C., Lee, S.-D. and Wu, J.-C. (2008), Natural history and prognostic factors of primary biliary cirrhosis in Taiwan: a follow-up study up to 18 years. Liver International, 28: 1305–1313. doi: 10.1111/j.1478-3231.2008.01715.x
- Issue online: 5 SEP 2008
- Version of Record online: 13 MAR 2008
- Received 23 November 2007Accepted 14 January 2008
- antimitochondrial antibody;
- primary biliary cirrhosis;
Purpose: The natural history of primary biliary cirrhosis (PBC) has been little studied in Asia. We conducted a Taiwanese cohort study on the natural history of PBC and analysed the prognostic factors.
Methods: This study enrolled 96 consecutive PBC patients between 1985 and 2006 to evaluate the baseline characteristics and outcomes.
Results: There were 74 females and 22 males. Eighty-five were positive for antimitochondrial antibodies in sera, and 11 were negative. The clinical manifestations and prognosis were similar between these two groups. In a median follow-up of 47.5±55.8 months, 27 patients died. Multivariate analysis indicated that the independent prognostic factors were serum albumin (P=0.021), creatinine (P=0.033) and ursodeoxycholic acid treatment (P=0.008). Besides, 42 patients developed adverse outcomes. Albumin (P<0.001), bilirubin (P=0.019) and prothrombin time (PT) (P=0.010) were significant factors. Moreover, a Mayo risk score <5, a Model for End-Stage Liver Disease (MELD) score <6, a Child–Pugh stage A and early liver histology were associated with favourable outcomes.
Conclusion: Serum albumin, bilirubin and PT were independent prognostic factors of adverse outcomes for Taiwanese PBC patients. Besides, the Mayo risk score, the MELD score, the Child–Pugh stage and liver histology were also validated to predict survival.