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What are ‘true normal’ liver stiffness values using FibroScan®?: a prospective study in healthy living liver and kidney donors in South Korea

Authors

  • Seung Up Kim,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
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  • Gi Hong Choi,

    1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    2. Liver Cirrhosis Clinical Research Center, Seoul, Korea
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    • *Contributed equally to this work.

  • Woong Kyu Han,

    1. Department of Urology, Yonsei University College of Medicine, Seoul, Korea
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    • *Contributed equally to this work.

  • Beom Kyung Kim,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
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    • *Contributed equally to this work.

  • Jun Yong Park,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Liver Cirrhosis Clinical Research Center, Seoul, Korea
    3. Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
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  • Do Young Kim,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Liver Cirrhosis Clinical Research Center, Seoul, Korea
    3. Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
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  • Jin Sub Choi,

    1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    2. Liver Cirrhosis Clinical Research Center, Seoul, Korea
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  • Seung Choul Yang,

    1. Department of Urology, Yonsei University College of Medicine, Seoul, Korea
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  • Eun Hee Choi,

    1. Department of Biostatistics, Yonsei University College of Medicine, Seoul, Korea
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  • Sang Hoon Ahn,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Liver Cirrhosis Clinical Research Center, Seoul, Korea
    3. Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
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  • Kwang-Hyub Han,

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Liver Cirrhosis Clinical Research Center, Seoul, Korea
    3. Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
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  • Chae Yoon Chon

    1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
    2. Liver Cirrhosis Clinical Research Center, Seoul, Korea
    3. Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
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Correspondence
Do Young Kim, Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Sodaemun-gu, Seoul 120-752, Korea
Tel: +82 2 2228 1992
Fax: +82 2 393 6884
e-mail: dyk1025@yuhs.ac

Abstract

Aims: To identify the normal range of liver stiffness (LS) values by recruiting healthy living liver and kidney donors in South Korea.

Methods: Liver stiffness measurement (LSM) was performed in 69 healthy living liver and kidney donors who were admitted for transplantation. None of the subjects suffered from diabetes mellitus, hypertension, hepatitis B virus infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or metabolic syndrome.

Results: LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available liver histology, eight showed normal liver histology and four showed liver steatosis of <5% of the hepatocytes. The mean age of our study population was 38.9 ± 11.9 years (35 men and 34 women), with a mean LS value of 4.6 ± 0.5 kPa (range 3.3–5.6 kPa). LS values were not significantly different between men (4.6 ± 0.6 kPa) and women (4.5 ± 0.5 kPa, P=0.636), nor were they significantly different according to age (P=0.851). Using the fifth and 95th percentiles, we determined the normal range of LS values to be 3.9–5.3 kPa.

Conclusions: We identified the normal range of LS values and found that LS values were not significantly influenced by age and gender.

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