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A double-blind, randomized, placebo-controlled trial of intravenous l-ornithine–l-aspartate on postural control in patients with cirrhosis


Monika Schmid, MD, Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Währingergürtel 18-20, A-1090 Vienna, Austria
Tel: +43 1 40400 4741
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Introduction: Hepatic encephalopathy (HE) is a complication of liver disease. Several treatments have been introduced but only l-ornithine–l-aspartate (LOLA) shows proven efficacy. This double-blind, randomized, placebo-controlled trial evaluated the effect of LOLA on postural control in cirrhotics.

Methods: Forty patients were randomized to either LOLA or a placebo. HE was evaluated by psychometric testing (PSE Syndrome Test) and critical flicker frequency (CFF). Posturography [equilibrium score (ES)] provided information regarding postural control. Peripheral blood was analysed for ammonia concentration (NH3) and the partial pressure of ammonia (pNH3).

Results: Both groups were comparable regarding baseline variables. Posturography and PSE Syndrome Test improved in both groups; improvement was greater in the LOLA group (ES: 5.3%; PSE: 1.9) compared with the placebo (ES: 3.9%; PSE: 1.3) but did not reach significance (ES: P=0.3; PSE: P=0.5). CFF remained unchanged during treatment and between groups (P=NS). NH3 decreased in the LOLA group (Δ: −15 μmol/L) and slightly increased in the placebo group (Δ: 11.1 μmol/L), but the differences did not reach statistical significance (P=0.07). pNH3 remained largely unchanged (LOLA Δ: −1.2 × 10−5 mmHg vs. placebo Δ: −0.3 × 10−5 mmHg; P=0.21).

Conclusion: In the LOLA group, an improvement of posturographic control and PSE Syndrome Test was observed, but a similar improvement was also achieved by the placebo. In LOLA, ammonia levels tended to decrease while they tended to increase in the placebo group. LOLA might augment the improvement achieved by intravenous fluids alone but a larger cohort will be needed to show this effect with statistical significance.