Interaction of alcohol intake and cofactors on the risk of cirrhosis
Article first published online: 14 MAY 2010
© 2010 John Wiley & Sons A/S
Volume 30, Issue 6, pages 867–870, July 2010
How to Cite
Stroffolini, T., Cotticelli, G., Medda, E., Niosi, M., Del Vecchio-Blanco, C., Addolorato, G., Petrelli, E., Salerno, M. T., Picardi, A., Bernardi, M., Almasio, P., Bellentani, S., Surace, L. A. and Loguercio, C. (2010), Interaction of alcohol intake and cofactors on the risk of cirrhosis. Liver International, 30: 867–870. doi: 10.1111/j.1478-3231.2010.02261.x
- Issue published online: 31 MAY 2010
- Article first published online: 14 MAY 2010
- Received 19 January 2010Accepted 29 March 2010
Objective: Evaluation of the interaction between alcohol intake and cofactors [hepatitis B virus (HBV), hepatitis C virus (HCV), body mass index] and coffee consumption on the risk of cirrhosis.
Design: Seven hundred and forty-nine consecutive patients with chronic liver disease referring to units for liver or alcohol diseases in Italy during a 6-months period. Teetotalers were excluded. The odds ratios (OR) for cirrhosis were evaluated using chronic hepatitis cases as the control group.
Results: An alcohol intake of more than 3 units/day resulted associated with the likelihood of cirrhosis both in males (OR 4.3; 95% CI=2.5–7.3) and in females (OR 5.7; 95% CI=2.3–14.5). A multiplicative interaction on the risk of cirrhosis between risky alcohol intake and HBsAg or HCV-Ab/HCV-RNA positivity was observed. A reduction of cirrhosis risk was observed in subjects consuming more than 3 alcohol units/day with increasing coffee intake. The OR for the association with cirrhosis decreased from 2.3 (95% CI=1.2–4.4) in subjects drinking 0–2 cups of coffee/day to 1.4 (95% CI=0.6–3.6) in those drinking more than 2 cups/day.
Conclusions: In subjects with an alcohol intake >3 units/day the coexistence of HBV or HCV multiplies the risk of cirrhosis. Coffee represents a modulator of alcoholic cirrhosis risk.