Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study
Article first published online: 21 MAY 2010
© 2010 John Wiley & Sons A/S
Volume 30, Issue 7, pages 1049–1058, August 2010
How to Cite
Zarski, J.-P., Sturm, N., Desmorat, H., Melin, P., Raabe, J.-J., Bonny, C., Sogni, P., Pinta, A., Rouanet, S., Babany, G., Cheveau, A. and Chevallier, M. (2010), Non-invasive assessment of liver fibrosis progression in hepatitis C patients retreated for 96 weeks with antiviral therapy: a randomized study. Liver International, 30: 1049–1058. doi: 10.1111/j.1478-3231.2010.02265.x
- Issue published online: 7 JUL 2010
- Article first published online: 21 MAY 2010
- Received 17 September 2009Accepted 4 April 2010
- blood tests of fibrosis;
- chronic hepatitis C;
- liver fibrosis;
Background: The efficacy of a maintenance therapy in non-responder patients with chronic hepatitis C has been essentially evaluated by histological semiquantitative scores.
Aim: The aim was to evaluate the efficiency of 2 years of treatment with peginterferon α-2a vs α-tocopherol in these patients by histology, morphometry and blood markers of fibrosis.
Method: Hundred and five HCV patients with a Metavir fibrosis score≥2 were randomized to receive peginterferon α-2a 180 μg/week (PEG) (n=55) or α-tocopherol (TOCO) 1000 mg/day (n=50) for 96 weeks. The primary endpoint was improvement or stabilization of the Metavir fibrosis score by biopsy performed at week 96. Secondary endpoints included a quantitative assessment of fibrosis by morphometry and changes in blood markers of fibrosis.
Results: There was no difference at baseline between PEG and TOCO according to the metavir (83.3 vs 86.8%, P=0.751) stage. The median fibrosis rate, measured with morphometry was 2.72 and 2.86% at day 0, and 3.66 and 2.82% at week 96, in the PEG and TOCO groups (P=0.90) respectively. However, the percentage of patients with metavir activity grade improvement was significantly higher in the PEG group vs the TOCO group (52.8 vs 23.7%, P=0.016). Non-invasive markers analysis did not show any significant change in both groups.
Conclusion: Long-term therapy with peginterferon α-2a did not reduce liver fibrosis degree assessed by morphometry and blood tests as compared with α-tocopherol. Blood tests could be useful to assess liver fibrosis changes in clinical trials.