*Mr. David Lloyd had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Renal effects of microwave ablation compared with radiofrequency, cryotherapy and surgical resection at different volumes of the liver treated
Version of Record online: 1 JUN 2010
© 2010 John Wiley & Sons A/S
Volume 30, Issue 9, pages 1305–1314, October 2010
How to Cite
Ahmad, F., Gravante, G., Bhardwaj, N., Strickland, A., Basit, R., West, K., Sorge, R., Dennison, A. R. and Lloyd, D. M. (2010), Renal effects of microwave ablation compared with radiofrequency, cryotherapy and surgical resection at different volumes of the liver treated. Liver International, 30: 1305–1314. doi: 10.1111/j.1478-3231.2010.02290.x
- Issue online: 1 SEP 2010
- Version of Record online: 1 JUN 2010
- Received 15 February 2010Accepted 10 May 2010
- liver ablation;
- liver resection;
- renal damage
Background: Renal changes after microwave tissue ablation (MTA) were compared with those following hepatic resection, cryotherapy (CRYO), and radiofrequency ablation (RFA). Structural damage producing renal impairment has been assessed directly by examining tissue specimens and by serum analysis for two sensitive biomarkers, retinol binding protein (RBP) and the heat shock protein 70 (HSP-70) for each modality at different ablation volumes.
Methods: Live rats underwent MTA, surgical resection, CRYO or RFA of 15, 33 or 66% of total hepatic volume. Urine and tissue samples were collected at the time of death. Percentage of tubules with casts and glomerular damage, tissue expression of HSP-70 and urine RBP were evaluated and compared. Behaviour of the animals was also assessed by means of five different parameters and combined to produce a response score.
Results: All RFA and CRYO rats undergoing 66% died and these animals had >60% of damaged tubuli and 8% of altered glomeruli. No animals treated by MTA or surgical resection died. Cut-off values (those predicting fatal treatments) could be identified for levels of HSP-70 and RBP.
Conclusions: Large volume MTA is associated with a significant reduced renal damage and is well tolerated compared with RFA and CRYO.