Association of mannose-binding lectin-2 gene polymorphism with the development of hepatitis C-induced hepatocellular carcinoma
Article first published online: 15 APR 2011
© 2011 John Wiley & Sons A/S
Volume 31, Issue 7, pages 1006–1012, August 2011
How to Cite
Eurich, D., Boas-Knoop, S., Morawietz, L., Neuhaus, R., Somasundaram, R., Ruehl, M., Neumann, U. P., Neuhaus, P., Bahra, M. and Seehofer, D. (2011), Association of mannose-binding lectin-2 gene polymorphism with the development of hepatitis C-induced hepatocellular carcinoma. Liver International, 31: 1006–1012. doi: 10.1111/j.1478-3231.2011.02522.x
- Issue published online: 6 JUL 2011
- Article first published online: 15 APR 2011
- Received 18 October 2010, Accepted 10 March 2011
- genetic variants;
- liver explants;
Background: Development of end-stage liver and graft disease is suspected to be partially determined by the individual genetic background. Mannose-binding lectin (MBL) is an important immunomodulatory factor, which is supposed to be involved in complement activation and oncogenesis. Genetic polymorphisms of MBL-2 alter MBL functionality. The aim of our study was to determine the prevalence of MBL-2 polymorphism (rs7096206) in hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) based on histological analysis of explanted livers in patients undergoing liver transplantation (LT).
Methods: One hundred and seventy-seven patients, who underwent LT for HCV-induced liver disease, were genotyped for MBL-2 by TaqMan genotyping assay. Sixty-two patients with histologically confirmed HCC were compared with 115 patients without HCC. MBL-2 genotypes were corelated with the growth patern, tumour size and pretransplant α-fetoprotein (AFP) level of HCC patients.
Results: The prevalence of GG/GC genotypes was significantly higher among HCC patients compared with tumour-free explanted livers (P=0.004; odds ratio 2.5; 1.3–4.8). GG/GC genotype group was significantly associated with the size of HCC (P=0.022), higher pretransplant AFP level (P=0.010) and bilobar tumour growth (P=0.038). Furthermore, CC genotype was found to be significantly more frequent in AFP-negative HCCs (P=0.002).
Conclusion: Mannose-binding lectin-2 polymorphism seems to be involved in the development of pretransplant HCV-induced HCC and should be further investigated as potential risk factor for HCV-associated carcinogenesis.