Hyperprolactinaemic Amenorrhoea in Hong Kong

Authors

  • Lawrence C. H. Tang,

    Corresponding author
    1. Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Hong Kong
      Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Hong Kong.
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    • 1

      Lecturer.

  • M. L. Sung,

    1. Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Hong Kong
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    • 2

      Formerly Lecturer.

  • H. K. Ma

    1. Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Hong Kong
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    • 3

      Professor.


Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Hong Kong.

Abstract

Summary: In a retrospective study of 595 patients attending the Menstrual Disorder Clinic from January, 1978 to December, 1981, 92 patients (15.5%) had raised serum prolactin (PRL) levels (>25 ng/ml) on 2 or more separate occasions with a mean (±S.E.M.) value of 67.1 ± 2.5 ng/ml. Galactorrhoea was found in 27.2% of the hyperprolactinaemic patients. Primary amenorrhoea was observed in 1 patient (1.1%) with serum PRL level of 68 ng/ml. Secondary amenorrhoea of longer than 6 months' duration occurred in 61 patients (66.3%) with mean PRL level 84.2±3.3 ng/ml. The 30 patients (32.6%) with irregular menstruation had a mean PRL level of 47.2±3.3 ng/ml.

Investigations revealed that 43 patients (46.7%) had idiopathic hyperprolacti naemia, 14 patients (15.4 %) had drug induced hyperprolactinaemia and 1 patient (1.1%) had hypothyroidism; 18 patients (19.5%) had suspected pituitary microadenoma and 16 patients (17.2%) had abnormal radiographic findings. Bromocriptine treatment was given to 38 patients, 13 with abnormal tomographic findings (mean serum PRL>100ng/ml); 18 with suspected pituitary microadenoma (mean serum PRL 94±2.7 ng/ml) and 7 with idiopathic hyperprolactinaemia (mean serum PRL 65±4.7 ng/ml). All patients (38/38) responded to treatment with restoration of menstruation and cessation of galactorrhoea within 1 to 3 months. Mean PRL level was 21.6±5.2 ng/ml at the time of response. Thirteen patients subsequently became pregnant and all delivered healthy babies.

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