Umbilical cord plasma homocysteine concentrations at delivery in pregnancies complicated by pre-eclampsia

Authors


  • The opinion and assertions contained herein are the private views of the authors and are not to be construed as official or reflecting views of the Department of Defense, Department of the Army, Department of the Air Force, or Department of the Navy.

: Dr Everett F. Magann, Department of Obstetrics and Gynecology, Naval Medical Center-Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708-2197, USA. Email: Everett.Magann@med.navy.mil

Abstract

Aim: To determine whether homocysteine concentrations in umbilical cord plasma of neonates born to mothers with pre-eclampsia are elevated compared to concentrations in neonates born to normotensive women.

Method: Maternal blood from eight women with pre-eclampsia and ten women without pre-eclampsia was collected on admission for labour. Cord blood was collected from these same pregnancies at delivery. Plasma was extracted and stored at −70°C. Samples were batch-analysed for homocysteine.

Result: Maternal plasma homocysteine levels were observed to be significantly higher in the pregnancies complicated by pre-eclampsia compared to the control pregnancies (P = 0.043) with median levels of 5.4 µmol/L (interquartile range (IQR) 4.6–7.9; range 3.6–16.7) versus 4.1 µmol/L (IQR 3.4–5.1, range 3.1–6.7). Homocysteine concentrations in umbilical cord plasma in pregnancies complicated by pre-eclampsia were also significantly higher compared to those in normotensive pregnancies (P = 0.016) with median concentration levels of 5.3 µmol/L (IQR 4.8–7.2, range 2.5–16.6) versus 3.8 µmol/L (IQR 2.8–4.4, range 0.8–1.6).

Conclusion: Both maternal and umbilical cord plasma homocysteine concentrations were elevated in pregnancies complicated by pre-eclampsia compared to normotensive controls.

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